David Managadze Email & Phone Number

Menlo Park, CA, US

Mountain View, CA, US

Mountain View, CA, US

• Architected and led implementation of POSEIDON - City of Hope’s multiyear multimillion dollar program to build precision oncology platform that automatically integrates, harmonizes, and ingests wide variety of.
• Designed and executed large scale multi-faceted solutions that required devising novel scientific algorithms and data ingestion strategies.
• Interacted with potential clients; worked with Sales and Program Management teams to evolve client requests into solution architectures as well as author RFP responses and statements of work.
• Analyzed large amounts of clinical, genomic, multi-omic, single cell transcriptomics, and other types of data; used big data analysis tools such as Apache Spark, Koalas, Pandas.
• Designed and conducted trainings for clients to facilitate understanding and popularization of the DNAnexus’ Titan and Apollo platforms.
• Mentored junior scientists and new colleagues to on-board, spread knowledge, and establish coding, reproducibility, and various standards and conventions.

Franklin Lakes, New Jersey, US

• Managed a cross-functional team of bioinformatics scientists and software engineers to create modern cloud-based scalable web applications for revolutionary large scale single-cell genomics analyses that are based on.
• Managed projects since their inception: interacted with wet lab scientists and came up with algorithms, interacted with sales and marketing and planned project roadmaps, defined project requirements and feature sets.
• Employed modern Agile software development practices (daily scrums, sprints, user stories, backlog,...) to develop products fast; played various roles including the product owner, scrum master, technical team lead, and.
• Architected cloud-based software based on Amazon AWS cloud, Python, Flask, PostgreSQL, DynamoDb, Ansible, Terraform, Arvados, etc; designed and implemented secure virtual private cloud and network infrastructure.
• Created and managed modern software development and deployment infrastructure consisting of team collaboration (Confluence) and issue management (JIRA) systems, source code repositories (Bitbucket, GitHub), software.

Franklin Lakes, New Jersey, US

• Interacted with wet lab scientists and other stakeholders, came up with bioinformatic algorithms of an important bioinformatic pipeline.
• Planned project roadmaps, defined project requirements and feature sets.
• Architected bioinformatics software, took major part in implementation.

Cellular Research has been acquired by Becton Dickinson (aka BD) and became a part of BD Genomics division.

Bethesda, MD, US

• Restored legacy HomoloGene pipeline, added new species and created recent public releases.
• Developed new improved HomoloGene pipeline using Python and NoSQL, with better sensitivity, specificity, richer functionality, ability to easily add new species, better data automation, and user interface.
• Developed very large, ultra-high throughput Genome Annotation Pipeline (Gpipe) based on SGE computer cluster and AWS cloud that increased annotation speed and quality many times.
• Explored new algorithms of genome annotation based on RNA-Seq using Python, R, Perl, awk, Bash, SQL.
• Improved user experience by developing public applications in Python and integrating the pipeline output with other NCBI resources e.g. RefSeq, Sequence Viewer (NCBI’s genome browser) using XML and XSLT.
• Created SAM/BAM specifications to convert Gpipe output and store into public FTP.

Bethesda, MD, US

• Eugene Koonin's Group of Evolutionary and Comparative Genomics
• Studied expression and evolution of long non-coding RNAs (lncRNAs) by genomic analysis of RNA-seq, microarray and EST data; published several high-impact papers on this hot topic.
• Studied roles of chimeric genes in cancer biology (results published). For this project, wrote bioinformatics pipelines in Perl and Python for SGE computer cluster to analyze EST and RNA-seq data.

Bethesda, MD, US

Reed Wickner's LabAdvisor: Daniel MasisonStudied prions causing diseases in humans using yeast as a model organism; discovered protein region most sensitive and important to [PSI+] prion destabilization.

Bochum, Nordrhein-Westfalen, DE

• Mentored a graduate student in his diploma work. Our work was fruitful: he is my co-author in two papers (later, he continued his MD/PhD at our laboratory.).
• Mentored undergraduate medical students in course works.
• Assisted biochemistry professor: supervised groups of undergraduate students in biochemistry laboratory and assessed their work.

Vienna, AT

• Planned Mission’s IT strategy, LAN/WAN infrastructure, satellite communication with branch offices.
• Set up systems of automatic deployment and configuration that improved user experience.
• Administered Novell eDirectory Services, user accounts, ZENworks and GroupWise systems;
• Created/managed internal networks in remote offices and organized satellite links to head office and central servers.
• Resolved user questions and routine IT-related problems.

• Converted intranet to Linux, set up firewall, proxy and web servers, and created company’s first web site that improved security, communication ability, and web presence.
• Administered Internet gateway-, proxy, firewall, DNS-, HTTP-, FTP- and MySQL servers.
• Designed billing and timesheet databases that made employees’ work simpler and more effective.

PL

• Led a team of data managers in successfully finalizing two major elections and creating mission reports.
• Designed election database, user interface, and data analysis and reporting tools.

• Led biochemistry production team.
• Led customer training effort.
• Designed novel clinical biochemistry and immunology diagnostic kits; implemented their assembly line.
• Wrote algorithms to adapt our diagnostic kits to our and customers’ automatic analyzers.
• Created light Laboratory Management System (LIMS) to support laboratory operations.

Phd, Magna Cum Laude, Cell Biology / Molecular Biology / Biochemistry

Master'S Degree (Msc), Biotechnology

Bachelor Of Science (Bsc), Biotechnology