I'm a seasoned Bioinformatician, passionate about exploring the intricacies of molecular structures, drug discovery, and life sciences in general. My career has been centered around academic and contract scientific research, as well as teaching.As a professional researcher, I specialize in a wide range of Structural Bioinformatics approaches such as Molecular Modeling, Molecular Dynamics, and Molecular Docking, along with experience in NGS and RNAseq analysis. My teaching roles, from instructing University courses for bachelor and master students to developing comprehensive educational programs, underline my dedication to knowledge-sharing and inspiring future scientists.My diverse experiences across academic and commercial projects, and the challenges encountered therein, have honed my soft skills in project management, planning, customer communication, collaborative leadership, and problem-solving, furthering my ability to translate scientific insights into practical applications.My goal is to keep contributing to the life sciences sector, utilizing my in-depth research and teaching experience, combined with my skills in management and customer relations. I'm driven by a passion for merging scientific methods with practical know-how, aiming to drive innovation and understanding in areas like drug discovery, biotechnology, medicine, and education
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Senior Research ScientistPirogov Russian National Research Medical University, Institute Of Translational Medicine Nov 2018 - Jul 2023Moscow, Russia+ Engaged in advanced research exploring specificity and affinity of interactions within T-cell receptor (TCR) and major histocompatibility complex-peptide (pMHC) complexes.+ Modeled more than 1500 TCR-pMHC complexes structures,elucidated the physical and structural aspects of TCR dimerization and peptide recognition, including the assembly of triple TCR-pMHC complexes and the influence of CDR3 loop variability.+ Analyzed contacting amino acid properties using machine learning techniquesSkills and approaches: Molecular modeling (Rosetta, TCRmodel), scripting (Rosetta, pipelines for high-throughput molecular modeling), statistical analysis of contacting residues properties (R, RF, RFE)
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Research ScientistInstitute Of Biomedical Chemistry Oct 2009 - Jul 2023Moscow, Russia+ Devised a novel in silico aptamer construction approach targeting thrombin and Cytochrome P450 51A1 proteins, yielding several aptamers with verified affinity and selectivity, backed by experimental correlation with predicted binding energy.+ Explored the impact of single amino acid mutations on thermostability and drug resistance of beta-lactamases, identifying key structural pathways influencing enzyme stabilization.+ Mapped the antibody-ganglioside interactions through molecular modelling, advancing understanding of Fab fragments of antibodies and gangliosides interaction dynamics.Skills and approaches : Molecular dynamics (Amber, Gromacs), molecular docking (Dock6, Autodock, Vina, CABS-dock), binding energy calculation (MM-PBSA), building and analysis of residue interaction networks (RING, Cytoscape), parametrization of molecules, quantum mechanics calculations, scripting
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System AdministratorInstitute Of Biomedical Chemistry Jan 2009 - Jan 2015Moscow, Russia
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Associate ProfessorMoscow Polytechnic University Sep 2016 - Feb 2023Moscow, RussiaDeveloped and have been instructing a comprehensive semester program on'Introduction to Bioinformatics' and 'Basics of Molecular Biology' -
CeoItbiotech Oct 2012 - 2023Moscow, Russia+ Successfully conducted an in-depth analysis of ligand-protein interactions as a part of adrug discovery project+ Constructed affine peptides for receptor molecules within the framework of a drug discovery project + Performed molecular modeling for the creation of accurate and detailed scientific illustrations
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Research ScientistSkolkovo Institute Of Science And Technology Nov 2016 - Nov 2018Moscow, Russia+ Led comprehensive analysis of gene expression profiles in hematopoietic stem cells+ Conducted statistical analysis in R, ANOVA analysis, analysis of RNAseq data using DESeq, PCA analysis, enrichment analysis, gene network analysis.Skills and approaches : Statistical analysis in R, normalization, ANOVA analysis, analysis of RNAseq data using DESeq, PCA analysis, enrichment analysis, gene network analysis -
Expert In Life SciencesAwtech Aug 2014 - Nov 2015
Dmitrii Shcherbinin, Ph.D Education Details
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Bioengineering And Bioinformatics
Frequently Asked Questions about Dmitrii Shcherbinin, Ph.D
What is Dmitrii Shcherbinin, Ph.D's role at the current company?
Dmitrii Shcherbinin, Ph.D's current role is Bioinformatician | Expert in Molecular Modeling | Experienced Lecturer and Educational Course Creator.
What schools did Dmitrii Shcherbinin, Ph.D attend?
Dmitrii Shcherbinin, Ph.D attended Lomonosov Moscow State University (Msu).
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