Dmitrii Shcherbinin, Ph.D

Dmitrii Shcherbinin, Ph.D Email and Phone Number

Bioinformatician | Expert in Molecular Modeling | Experienced Lecturer and Educational Course Creator
Dmitrii Shcherbinin, Ph.D's Location
Gothenburg, Västra Götaland County, Sweden, Sweden
About Dmitrii Shcherbinin, Ph.D

I'm a seasoned Bioinformatician, passionate about exploring the intricacies of molecular structures, drug discovery, and life sciences in general. My career has been centered around academic and contract scientific research, as well as teaching.As a professional researcher, I specialize in a wide range of Structural Bioinformatics approaches such as Molecular Modeling, Molecular Dynamics, and Molecular Docking, along with experience in NGS and RNAseq analysis. My teaching roles, from instructing University courses for bachelor and master students to developing comprehensive educational programs, underline my dedication to knowledge-sharing and inspiring future scientists.My diverse experiences across academic and commercial projects, and the challenges encountered therein, have honed my soft skills in project management, planning, customer communication, collaborative leadership, and problem-solving, furthering my ability to translate scientific insights into practical applications.My goal is to keep contributing to the life sciences sector, utilizing my in-depth research and teaching experience, combined with my skills in management and customer relations. I'm driven by a passion for merging scientific methods with practical know-how, aiming to drive innovation and understanding in areas like drug discovery, biotechnology, medicine, and education

Dmitrii Shcherbinin, Ph.D's Current Company Details

Bioinformatician | Expert in Molecular Modeling | Experienced Lecturer and Educational Course Creator
Dmitrii Shcherbinin, Ph.D Work Experience Details
  • Pirogov Russian National Research Medical University, Institute Of Translational Medicine
    Senior Research Scientist
    Pirogov Russian National Research Medical University, Institute Of Translational Medicine Nov 2018 - Jul 2023
    Moscow, Russia
    + Engaged in advanced research exploring specificity and affinity of interactions within T-cell receptor (TCR) and major histocompatibility complex-peptide (pMHC) complexes.+ Modeled more than 1500 TCR-pMHC complexes structures,elucidated the physical and structural aspects of TCR dimerization and peptide recognition, including the assembly of triple TCR-pMHC complexes and the influence of CDR3 loop variability.+ Analyzed contacting amino acid properties using machine learning techniquesSkills and approaches: Molecular modeling (Rosetta, TCRmodel), scripting (Rosetta, pipelines for high-throughput molecular modeling), statistical analysis of contacting residues properties (R, RF, RFE)
  • Institute Of Biomedical Chemistry
    Research Scientist
    Institute Of Biomedical Chemistry Oct 2009 - Jul 2023
    Moscow, Russia
    + Devised a novel in silico aptamer construction approach targeting thrombin and Cytochrome P450 51A1 proteins, yielding several aptamers with verified affinity and selectivity, backed by experimental correlation with predicted binding energy.+ Explored the impact of single amino acid mutations on thermostability and drug resistance of beta-lactamases, identifying key structural pathways influencing enzyme stabilization.+ Mapped the antibody-ganglioside interactions through molecular modelling, advancing understanding of Fab fragments of antibodies and gangliosides interaction dynamics.Skills and approaches : Molecular dynamics (Amber, Gromacs), molecular docking (Dock6, Autodock, Vina, CABS-dock), binding energy calculation (MM-PBSA), building and analysis of residue interaction networks (RING, Cytoscape), parametrization of molecules, quantum mechanics calculations, scripting
  • Institute Of Biomedical Chemistry
    System Administrator
    Institute Of Biomedical Chemistry Jan 2009 - Jan 2015
    Moscow, Russia
  • Moscow Polytechnic University
    Associate Professor
    Moscow Polytechnic University Sep 2016 - Feb 2023
    Moscow, Russia
    Developed and have been instructing a comprehensive semester program on'Introduction to Bioinformatics' and 'Basics of Molecular Biology'
  • Itbiotech
    Ceo
    Itbiotech Oct 2012 - 2023
    Moscow, Russia
    + Successfully conducted an in-depth analysis of ligand-protein interactions as a part of adrug discovery project+ Constructed affine peptides for receptor molecules within the framework of a drug discovery project + Performed molecular modeling for the creation of accurate and detailed scientific illustrations
  • Skolkovo Institute Of Science And Technology
    Research Scientist
    Skolkovo Institute Of Science And Technology Nov 2016 - Nov 2018
    Moscow, Russia
    + Led comprehensive analysis of gene expression profiles in hematopoietic stem cells+ Conducted statistical analysis in R, ANOVA analysis, analysis of RNAseq data using DESeq, PCA analysis, enrichment analysis, gene network analysis.Skills and approaches : Statistical analysis in R, normalization, ANOVA analysis, analysis of RNAseq data using DESeq, PCA analysis, enrichment analysis, gene network analysis
  • Awtech
    Expert In Life Sciences
    Awtech Aug 2014 - Nov 2015

Dmitrii Shcherbinin, Ph.D Education Details

Frequently Asked Questions about Dmitrii Shcherbinin, Ph.D

What is Dmitrii Shcherbinin, Ph.D's role at the current company?

Dmitrii Shcherbinin, Ph.D's current role is Bioinformatician | Expert in Molecular Modeling | Experienced Lecturer and Educational Course Creator.

What schools did Dmitrii Shcherbinin, Ph.D attend?

Dmitrii Shcherbinin, Ph.D attended Lomonosov Moscow State University (Msu).

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