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Associate Director with extensive experience leading oncology and preclinical research and development within the biotech industry, leveraging an intuitive blend of technical and professional competencies to support IND filing within highly regulated environments. Dynamic leader with a proven expertise in immunology-based techniques and robust skills in DMPK, drug disposition, in vitro assay development, in vivo study design, tissue distribution and fluorescence imaging and quantitation. Accomplished scientist utilizing excellent interpersonal skills to engage with stakeholders regarding a diverse set of biologic therapeutic modalities, including, but not limited to, agonist/antagonist antibodies, bispecifics, nanobodies, and antibody drug conjugates.Areas of Expertise:Oncology & Pre-Clinical R&DStrategic Team LeadershipSafety & Regulatory SubmissionsIND FilingCRO ManagementIn Vitro Assay Development, Qualification / ValidationDMPK / ADME / Tissue DistributionFlow CytometryTranslational ResearchIn Vivo Study Design & ExecutionIHC / Multiplex IFPartnership Building
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DirectorBiograph 55Sunnyvale, Ca, Us -
Associate DirectorTizona Therapeutics, Inc. Aug 2021 - PresentSouth San Francisco, Ca, Us• Provided strategic direction as the Research and Translational Team Lead responsible for overseeing the development of a first-in-class HLA-G antagonist antibody from antibody discovery to IND submission, and ultimately through to Phase 1a/1b clinical development. • Established a successful strategic partnership on TTX-080 with Gilead to support clinical development. • Provided strategic oversight for multiple preclinical programs in various phases of development ranging from target identification to drug candidate nomination. -
Senior Principal ScientistTizona Therapeutics, Inc. Aug 2015 - Aug 2021South San Francisco, Ca, Us• Directed and managed efforts to advance a development candidate to IND-enabling phase.• Led research activities for a therapeutic target to validate target biology and in vitro functional activity; determine feasibility of developing a therapeutic antibody.• Supported CD39 program development and IND-enabling in vivo studies by managing PK/PD studies, conducting drug assays, and performing receptor occupancy assays, ultimately supporting successful partnership with AbbVie for clinical development of TTX-030 (a first-in class anti-CD39 antagonist antibody).• Took on multiple functional roles as the first scientist hired at Tizona Therapeutics to establish operational research laboratories at two separate sites. • Provided oversight and management for lab operations pertaining to safety, county/state regulatory guidelines, waste management, and sample storage.
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Senior ScientistMerck Research Laboratories Mar 2006 - Aug 2015Rahway, New Jersey, Us• Leveraged in-depth experience in biologics drug research and development targeting immunomodulatory receptors in oncology and autoimmune diseases to serve in a leadership role and as co-lead for ADC program interfacing with functional groups; coordinated studies and managed weekly meetings. • Performed DMPK support for multiple programs by executing studies in tissue distribution, biomatrix stability, protein-protein interaction, anti-drug antibody response, cell metabolism, and drug uptake. • Played key roles in R&D of anti-GITR agonist antibody program as well as other immunomodulatory receptors (from lead identification to preclinical support) focused on tumor immunotherapy.• Responsible for preclinical safety assessments. Collaborated with research organization to finalize a protocol for an acute cytokine release assay and transferred assay to bioanalytics group. -
Scientific ConsultantTrue Biosystems Inc Sep 2012 - Jun 2013Participated in team meetings to advise on the design of an absorbance module for a multi-mode spectrophotometer. Documented which Life Science absorbance assays should be accommodated to fit the widest market potentialProposed a set of overall specifications for an absorbance module. Performed a comparative analysis on competitive instruments.
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Research AssociateGenencor, A Danisco Division Mar 2000 - Dec 2005Rochester, Ny, UsDeveloped and validated assays for the detection and quantification of therapeutic proteins in PK and immunogenicity experimentsAssessed stability of therapeutic molecules in biological matrices using HPLC and ELISAProvided IHC staining data from cell lines, tumor models, and human cancer arrays to determine disposition of current generation antibodies and screen for target antigen expressionDetermined relative cytotoxicity of known and potential therapeutic molecules on human tumor cell lines to expedite drug selectionSupported in-vivo group in the development of oncology xenograft models for preclinical drug developmentDeveloped transfected human tumor cell lines that expressed the human melanoma antigen p97 used for preliminary studies to assess drug efficacyLead contact and coordinator with GLP laboratory for sample delivery, analysis scheduling, and study data and report transfer; identified stability issues that resulted in improvements in analysis methods
Doug Hodges Skills
Doug Hodges Education Details
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University Of California, DavisB.S. Genetics
Frequently Asked Questions about Doug Hodges
What company does Doug Hodges work for?
Doug Hodges works for Biograph 55
What is Doug Hodges's role at the current company?
Doug Hodges's current role is Director.
What is Doug Hodges's email address?
Doug Hodges's email address is dh****@****hoo.com
What schools did Doug Hodges attend?
Doug Hodges attended University Of California, Davis.
What skills is Doug Hodges known for?
Doug Hodges has skills like Biotechnology, Assay Development, Elisa, Molecular Biology, Drug Discovery, Protein Purification, Immunology, Cell Biology, Life Sciences, Sds Page, Cell, Protein Chemistry.
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