Medicinal Chemistry, Structure Based Design, and CRO Management Consultant

Highly experienced, motivated, team-oriented and goal-driven medicinal chemist with >25 years of experience. As a drug designer and program manager, I have significantly impacted pharmaceutical small molecule drug discovery and development across multiple target classes (PPIs, kinases (type I and type II), GPCRs, epigenetic targets, and small molecule drug conjugates (SMDCs). As a member of several multi-disciplinary project teams, I have made important contributions to the discovery of multiple clinical candidates, establishing a reputation as a self-starter who performs well under pressure, thrives in a fast-paced environment and consistently delivers on goals.▪ Project lead for several optimization programs, including small molecule type II Kinase inhibitors and drug conjugate (SMDC) programs▪ Highly skilled at using structure-based drug discovery to help drive programs towards candidate selection (ie, Schrodinger’s Live Design)▪ Experienced medicinal chemist with a strong background in interpreting structure-activity relationships for optimizing drug-likeness, including physicochemical properties, potency, selectivity, ADME and PK▪ Led HTS to hit exploratory campaigns generating high quality small molecule leads from initial hits to enable critical target validation studies and program go/no go decisions▪ Highly experienced in CRO management (US, India, and Chinese)▪ Exceptional hands-on synthetic chemist who consistently and efficiently delivers final products▪ Expertise in multi-step organic synthesis from mg to kg scale and high speed analoging/focused library generation▪ Experienced supervisor and manager- Supervisor of full-time associate staff, inventory temp., and summer interns- Managed up to 25+ FTE scientists at CRO to high productivity

Research associate in the medicinal chemistry department