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Energetic, imaginative scientific leader successful in visualizing, communicating, delivering innovative, cross-disciplinary pharmaceutical/biotech research programs translated from preclinical to early clinical POC trials for multiple disease indications. Significant accomplishments in the discovery, characterization, and application of scientific targets for the development of small molecule and biopharmaceutical therapeutics for inflammation, immunology, CVD, neuroscience, and oncology targets. Experienced in initiation, management, delivery of successful research collaborations.SIGNIFICANT ACCOMPLISHMENTS IN DRUG DISCOVERY AND DEVELOPMENT:• Drug Discovery in acute/chronic inflammatory pathways. Highlights: discovery/characterization of FLAP, FLAP inhibitors for respiratory/CVD, transition to clinical development; purification/characterization of caspase-1 for RA, discovery/characterization of other caspases for control of apoptosis; signal transduction in inflammatory pathways.• Translational Medicine: Biomarker assessment for 7 asset classes late exploratory discovery to Ph2 clinical development, Inflam, CVD, NS, Onc. • Clinical Development: 7 Inflam Ph1, Ph2 Clin programs, PK/PD, disease, patient selection assays, clinical site presentor.• Collaborative Programs: Estab collaborative research networks, codeveloper/scientific manager 16 research projects, organizer of NYAS and Translational Medicine Research Collaboration symposia.Translational Medicine | Biomarker Development | Assay ValidationClinical Pharmacology | Cross-sectional | Longitudinal | Observational Clinical TrialsGenomics | Proteomics | Clinical Imaging | Diagnostics | Immunoassay Program Initiation | Project Management | Matrix LeadershipAcademic | CRO | Precompetitive CollaborationsDiscovery | In Vitro | Cellular | HTS | High Content ImagingReceptors | Signal Transduction | Small Molecules | BiotherapeuticsInflammation | Respiratory | Cardiovascular | Oncology
Arroyo Biosciences, Llc.
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Chief Scientific OfficerArroyo Biosciences, Llc. Apr 2017 - Present
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Pharmaceutical And Biotechnology ConsultingMiller Associates, Llc 2010 - PresentPreclinical drug discovery, translational medicine, early clinical development, diagnostic and biomarker selection, validation, and analysis for small molecule and biotherapeutic assets. Leadership in the strategy, development, and project management of a broad research portfolio and direction of multiple cross-functional internal and external matrix-driven teams. Expertise in diverse disease targets within inflammation, immunology, cardiovascular and oncology therapeutic areas. Experienced in diverse laboratory and diagnostics assays, platforms, and technologies.
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Chief Scientific OfficerSpr Biosciences Nov 2015 - Jun 2016Development of therapeutics for the treatment of pulmonary, cardiovascular, and fibrotic diseases.
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Director Of ResearchGenesis Biotechnology Group Jun 2013 - Oct 2014Hamilton, Nj, UsLead the research efforts for preclinical drug discovery and diagnostic assays within the affiliated therapeutic divisions concentrating on infectious disease, inflammation and immunology, oncology, metabolic, and neurodegenerative diseases. -
Director | Translational MedicineEisai Feb 2012 - Dec 2012Nutley, Nj, UsLead the Translational Medicine efforts for inflammatory, immunological, and vascular diseases in the Frontier Product Creation Unit. Provide expertise for the identification, validation, and use of multiple biomarkers for proof of pharmacology, mechanism, and concept for therapeutics in animal models in Discovery Research and human subjects in Clinical Development. -
Director | Discovery Translational MedicinePfizer 2009 - 2010New York, New York, UsDirect multiple clinical observational programs identifying soluble, pharmacogenomic, pharmacogenetic, proteomic, and imaging biomarkers for respiratory disease--COPD, asthma, and Cystic Fibrosis. -
Director | Discovery Translational MedicinePfizer 2006 - 2009New York, New York, UsDevelopment and leadership of inflammation translational medicine (TM) franchise, initiating and directing cross-functional biomarker programs in preclinical and clinical development for target validation, PD assessment, disease severity and progression, and patient characterization for small molecule and biotherapeutic assets focusing on respiratory and autoimmune disease.
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Senior Investigator | Dept Of Cardiovascular DiseasesMerck 2002 - 2005Rahway, New Jersey, UsDiscovery research laboratory and project team leader for the identification, supervision, and scientific management of eicosanoid programs for atherosclerosis and vascular inflammation treatment; supervision of direct reports and other laboratories for assay design and implementation, monoclonal antibody production, in vitro and cellular imaging assays, and X-Ray and NMR structure determination. -
Senior Investigator | Dept Of Immunology And InflammationMerck 1995 - 2002Rahway, New Jersey, UsResearch program director for the identification and development of exploratory programs for cytokine receptor antagonism, glucocorticoid receptor modulation, and inhibition of cellular signal transduction.
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Senior Research Fellow | Dept Of Immunology And RheumatologyMerck 1990 - 1995Rahway, New Jersey, UsDrug discovery project team leader for the identification, purification, characterization, and development of inhibitors to interleukin-1 beta converting enzyme (ICE, caspase-1) and related enzymes for treatment of rheumatological/autoimmune diseases.
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Research Fellow | Dept Of Biochemistry Of InflammationMerck 1982 - 1990Rahway, New Jersey, UsLaboratory director for the development and performance of in vitro and cellular assays for eicosanoid inhibitor research for respiratory diseases.
Douglas Miller Skills
Douglas Miller Education Details
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Harvard UniversityBiochemistry -
Rutgers UniversityMini-Mba | Global Biopharma Enterpreneurship
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University Of North DakotaChemistry | Mathematics | Psychology
Frequently Asked Questions about Douglas Miller
What company does Douglas Miller work for?
Douglas Miller works for Arroyo Biosciences, Llc.
What is Douglas Miller's role at the current company?
Douglas Miller's current role is Chief Scientific Officer at Arroyo Biosciences, LLC.
What is Douglas Miller's email address?
Douglas Miller's email address is do****@****ast.net
What is Douglas Miller's direct phone number?
Douglas Miller's direct phone number is +190880*****
What schools did Douglas Miller attend?
Douglas Miller attended Harvard University, Rutgers University, University Of North Dakota.
What skills is Douglas Miller known for?
Douglas Miller has skills like Drug Discovery, Immunology, Biotechnology, Assay Development, Biomarkers, Clinical Development, In Vitro, Pharmacology, Oncology, Biochemistry, Clinical Trials, Drug Development.
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