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At Rubius I lead the protein sciences group.At Novartis I was on projects in various disease areas that have involved compound target ID to early drug discovery efforts. In this position I worked on assay development (TR-FRET, SEC, FP, DSF, LC-MS, SPR, SEC-TID), protein design (designing protein sequence), protein purification (purified thousands recombinant proteins with various tags), protein biophysics/analytics, protein array technology, and protein/small molecule screening. I worked at Novartis (NIBR) in the Chemical Biology and Therapeutics department in the Chemical Biology hub.Bristol Myers Squibb (Adnexus) I was part of the protein sciences group. In that role I purified thousands of His-Tagged and untagged recombinant proteins across multiple programs to support high-throughput screening, assay development, biophysical and biochemical characterization.o Assay development: Time resolved fluorescence energy transfer (TR-FRET), LC-MS for size exclusion chromatography-target identification (SEC-TID), differential scanning fluorimetry (DSF), surface plasmon resonance (SPR), fluorescence polarization (FP), colorimetric and fluorescent assay formats.o Protein Expression systems: Escherichia Coli (E. Coli), Mammalian Cells (HEK293, CHO).o Protein purification, characterization, and quantification techniques: AKTA, SDS-PAGE, Analytical SEC, Nano Drop, UV- Spec, LC-MS, DSF, DSC, SEC-MALS.o Chromatography (pre-packed and self-packed): affinity, hydrophobic, ion exchange, size exclusion, custom resins.o Purification workstations: AKTA various models (GE), BioCad (Applied Biosystems), Profina (Bio-Rad), gravity (manual)o Protein refolding experimentso Quantification: BCA (bicinchoninic acid) assay and extinction coefficient based UV-VIS spectroscopy, LAL assay.o Characterization: SDS-PAGE, Western Blotting, size exclusion chromatography, LC-MS, DSC and DSF (thermal melt assays).o Automation: Beckman BioMek, GXII, LC-90, Sciclone LH3000, Aria, Masslynx.
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Moma TherapeuticsMoma TherapeuticsQuincy, Ma, Us
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Principal ScientistMoma Therapeutics Jul 2024 - PresentCambridge , Massachusetts, Us
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Senior Scientist IiMoma Therapeutics Jan 2022 - Jul 2024Cambridge , Massachusetts, UsI am leading Chemical Genomics (ChemG) efforts here at MOMA.The goal of this effort is to use a large protein panel to annotate binding pockets that are common or selective within specific protein classes. This involves protein design/engineering, protein production internally or at CRO's, technology development (externally and in-house), and database management.Techniques: Reagent production - Protein design, expression, purification, protein analytics.Binding assays - Thermal shift, ASMS, LC-MS ABPP, Intact mass, target engagement, SPR, activity assaysChemistry - Reversible, Covalent, and photo-affinity ligands
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Senior ScientistMoma Therapeutics May 2020 - Jan 2022Cambridge , Massachusetts, UsWorking to establish a chemical genomics platform at MOMA.
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Senior Scientist - Head Of Protein SciencesRubius Therapeutics Feb 2019 - Apr 2020Cambridge, Massachusetts, UsGroup Lead - managing and leading the protein sciences team at Rubius.Helped build the protein sciences group at Rubius by bringing in house protein production and protein analytics. developed protein expression in mammalian/bacterial systems and FPLC purification to produce mg to gram quantities.Involved in developing and optimizing the red blood cell platform by testing prototypes and cell attachment. -
Scientist - Head Of Protein ScienceRubius Therapeutics Jun 2017 - Feb 2019Cambridge, Massachusetts, UsGroup Lead - managing and leading the protein sciences team at Rubius.Helped build the protein sciences group at Rubius by bringing in house protein production and protein analytics. developed protein expression in mammalian/bacterial systems and FPLC purification to produce mg to gram quantities.Involved in developing and optimizing the red blood cell platform by testing prototypes and cell attachment.
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Scientist IiNovartis Institutes For Biomedical Research (Nibr) Mar 2015 - Jun 2017Basel, Baselstadt, Ch -
Scientist INovartis Institutes For Biomedical Research (Nibr) Jun 2013 - Mar 2015Basel, Baselstadt, ChScientist II (3/2015-6/2017)Scientist I (6/2013-3/2015)Chemical Biology and Therapeutics (CBT) - Chemical Biology hubAt Novartis I have worked on projects in various disease areas that have involved early stage drug discovery to compound target ID efforts. In this position I have worked on assay development (TR-FRET, SEC, FP, DSF, LC-MS, SPR, SEC-TID[ASMS]), protein design (designing protein sequence), protein purification (purified thousands of recombinant proteins with various tags), basic molecular biology, protein biophysics/analytics, protein arrays, and protein/small molecule screening.o Assay development: Time resolved fluorescence energy transfer (TR-FRET), LC-MS for size exclusion chromatography-target identification (SEC-TID), differential scanning fluorimetry (DSF), surface plasmon resonance (SPR), fluorescence polarization (FP), colorimetric and fluorescent assay formats.o Protein Expression systems: Escherichia Coli (E. Coli), Mammalian Cells (HEK293, CHO).o Protein purification, characterization, and quantification techniques: AKTA, SDS-PAGE, Analytical SEC, Nano Drop, UV- Spec, LC-MS, and DSF.o Chromatography (pre-packed and self-packed): affinity, hydrophobic, ion exchange, size exclusion.o Purification workstations: AKTA various models (GE), and gravity (manual)o Quantification: BCA (bicinchoninic acid) assay and extinction coefficient based UV-VIS spectroscopy.o Characterization: SDS-PAGE, Western Blotting, size exclusion chromatography, LC-MS, and DSF (thermal melt assays).o Automation: Beckman BioMek, GXII, Aria, Masslynx.
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Principal Research AssociateBristol-Myers Squibb Aug 2007 - Jun 2013Lawrence Township, Nj, UsPrincipal Research Associate (2012-2013)Senior Research Associate (2010-2012)Research Associate II (2009-2010)Research Associate I (2008-2009)Temporary Associate (2007-2008)· Protein Science representative for drug discovery program:o Communicate results to project team and guide progress that led to timely delivery of proteins.o Delivered purified proteins in timely manner that meets the teams’ needs.· Implemented new technologies that increased productivity of existing workflow:o Introduced auto-induction media for E. coli expression that increased shake flask productivity.o Developed a plate based chromatography screen that was full automated to determine the best purification conditions.o Helped developed a new tip based purification process.o Involved in the automation of high-throughput protein purification protocol (96 well format).o Ran protein analysis methods.o Performed protein conjugation using chemical modification. -
Marketing AssociateVision Biosystems Jun 2006 - Jan 2007Au· Telemarketing· Market analysis· Customer relations· Regional sales· Other duties, as required -
Laboratory AssistantInstitute Of Bioenergetics Mar 2005 - Sep 2005Colorado Springs, Co, Us· Basic rodent husbandry, cleaning, feeding, etc. · Autoclaved lab equipment · Web programming for lab· Chemical stocking· Other duties, as required
Doug Mclaughlin Skills
Doug Mclaughlin Education Details
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Umass BostonBiology -
Penn State UniversitySeparation And Purification Strategies For Biotechnology Products
Frequently Asked Questions about Doug Mclaughlin
What company does Doug Mclaughlin work for?
Doug Mclaughlin works for Moma Therapeutics
What is Doug Mclaughlin's role at the current company?
Doug Mclaughlin's current role is MOMA Therapeutics.
What is Doug Mclaughlin's email address?
Doug Mclaughlin's email address is dm****@****ail.com
What schools did Doug Mclaughlin attend?
Doug Mclaughlin attended Umass Boston, Penn State University.
What are some of Doug Mclaughlin's interests?
Doug Mclaughlin has interest in Professional Networking, Extreme Programming, International Travel, Community Theater, Skiing, Research, Architectural History, Gourmet Cooking, Running, Protein Chemistry.
What skills is Doug Mclaughlin known for?
Doug Mclaughlin has skills like Protein Chemistry, Protein Purification, Drug Discovery, Purification, Assay Development, Chromatography, Protein Expression, Sds Page, Western Blotting, Biochemistry, Elisa, Cell.
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