Dr. Marta Stolarczyk Email & Phone Number

Heidelberg, Bw, De

Heidelberg, Bw, De

Root, Switzerland, Ch

Scientific and strategic lead on a global clinical trial conducted in Europe, US and China(Successful delivery of the study)-cross-functional team management to deliver top line data in a timely manner for one of the global clinical trial (together with Medical Director)

Root, Switzerland, Ch

- relationship development with Key Opinion Leaders (KOLs) and Principal Investigators (PIs) in various countries: Germany, Poland, Netherlands and Belgium- exchange of the scientific knowledge with KOLs during various conferences (ESMO, ASCO, AACR. etc) and site visits- be on top of knowledge regarding following entities of cancers: NSCLC, Brain Metastasis, Pancreatic and Hepatic cancer, Ovarian cancer- feedback collection from PIs regarding Clinical Trial Protocol and implementation of Protocol Amendments - development of Clinical Trial strategy for start-up, recruitment and top line data delivery in close collaboration with Medical Director - management of patient enrollment and assurance that the patient eligibility criteria are met (acting as the right hand of medical director for European countries)- assurance the integrity of the clinical study data, assessment of protocol deviations and other medical issues - strong collaboration with Clinical Operators to support start-up activities, new site selection and support for operational activities on the open sites (including vendor management) - medical monitoring and data cleaning with strong collaboration with Medical Director, Clinical Operations Manager, Data Manager and Biostatics Manager- collaboration with Medical Affairs department on organization of webinars and other educational events for professionals (KOLs/PIs/side staff)

Raleigh, North Carolina, Us

- Implementation and monitoring of phase 3 and post-marketing studies to ensure sponsor in and investigator obligations are met and are compliant with applicable local regulatory requirements and ICH guidelines (projects for different sponsors: BMS, AstraZeneca, Roche and others)- Recruitment and evaluation of potential sites for participation in the late phase studies. - In-house site management that encompass: 1) clinical study tracking to ensure that the study files are current, accurate, and complete 2) collection, review, maintenance of essential document 3) close out activities4) liase with external clients and authorities to ensure adherence to the late phase study design5) primary point of contact for assigned study sites6) tracking patient enrollment, study supplies, and reviewing data entry efforts of assigned study sites7) performing clinical data review for enrolled patients, query resolution and assessing data discrepancies within clinical databases8) resolving internal and external clinical issues for client research projects9) reporting of Serious Adverse Event (SAE) according to project specifications

Heidelberg, Baden-Württemberg, De

Translational Oncology (lymphoma and leukemia).Establishment of the state of art microscopy based ex-vivo drug testing platform for patients with lymphoma (organotypic cultures of primary LN cells from lymphoma patient biopsies). ACHIEVMENTS:1) Development of 3D lymph node:- establishment of the unique biobanking procedure of lymph node lymphocytes and lymph node stromal cell isolated from patient lymph node biopsies, - co-culture of patient lymph node lymphocytes and stromal cells in 2D and 3D culture set-up- design of 3D culture material to meet the growth need of lymph node lymphocytes and lymph node stromal cells in one hydrogel drop - establishment of the confocal microscopy read out for viability of complex lymph node co-cultures under basal conditions and after drug treatment - drug testing on complex lymph node co-culture models- establishment of FACS panel to discriminate different cell types present in the lymph node stromal cell compartment2) SCSq of the lymph node lymphocytes: - establishment of the single cell transcriptome analysis (10x Genomics)3) Data analysis:- establishment of the quantitative analysis of the confocal microscopy pictures (z-stacks) in 3D volume in close collaboration with bioinformatic team at EMBL (advancement over maximal projection)Publication:Roider et al, Dissecting intratumour heterogeneity of nodal B-cell lymphomas at the transcriptional, genetic and drug-response levels, Nature Cell Biology, Jan2020

Rotterdam, Zuid-Holland, Nl

Studies on Airway inflammation and remodeling in Chronic Lung Diseases (in patient-based advanced airway models): The EGFR-ADAM17 axis controls inflammatory responses in Cystic Fibrosis and Chronic Obstructive Pulmonary Disease. Publications:2018, Stolarczyk et al, The EGFR-ADAM17 Axis in Chronic Obstructive Pulmonary Disease and Cystic Fibrosis Lung Pathology, Mediators Inflame 2018, Stolarczyk et al, Extracellular oxidation in cystic fibrosis airway epithelium causes enhanced EGFR/ADAM17 activity, Am J Physiol Lung Cell Mol Physiol.2016 Stolarczyk et al., ADAM17 and EGFR regulate IL-6 receptor and amphiregulin in COPD bronchial epithelial cells, Physiol Rep2016, Veltman et al., Correction of Lung Inflammation in a F508del CFTR murine Cystic Fibrosis model by the Sphingosine-1-Phosphate Lyase Inhibitor LX2931, Am J Physiol Lung Cell Mol Physiol2014, Palomo, et al., Role of IL-1β in experimental cystic fibrosis upon P.aeruginosa infection, PLoS One

Montreal, Qc, Ca

Fellowship for a project awarded by EMBO: the role of ADAM17 and EGFR in Cystic Fibrosis. It ended up with scientific publication:2018, Stolarczyk et al, Extracellular oxidation in cystic fibrosis airway epithelium causes enhanced EGFR/ADAM17 activity, Am J Physiol Lung Cell Mol Physiol.

Warsaw, Poland, Pl

Research assistance in pre-clinical studies concerning diabetes type 2 (ended with Master Degree). Review:Stolarczyk et al, Nuclear receptors PPAR as a drug target in metabolic disorders, Post Biochem

Short intern in the in vitro fertilisation clinic.

Ożarów Mazowiecki, Mazowieckie, Pl

Postdoctoral Researcher, Oncology And Cancer Biology

Phd, Lung Diseases: Copd And Cystic Fibrosis

Doctor Of Philosophy - Phd, Cystic Fibrosis

Msc In Molecular Biology, Diabetes And Other Metabolic Disorders

Bsc In Biotechnology, Biotechnology