Ganesh Sable Email & Phone Number

Pasadena, California, United States

Peptide and Protein engineering and conjugation chemistries towards 'peptide drug discovery'.

Edmonton, Alberta, Canada

Work on Peptide drug discovery which mainly includes: Macrocyclic Peptides, Radiolabeled-fluorescent labeled peptides, Phage-display peptide modifications, Conjugation chemistry, organic synthesis and medicinal chemistry.

Edmonton, Alberta, Canada

Research Supervisor: Prof. Ratmir DerdaField of Research: Peptide drug discovery, Phage-display post translational modification.Prime Goal of Research: Radio/Bio labeled Macrocyclic peptide drug discovery using phage-display technology.Project Features: Step-1: We establish the aqueous chemistry compatible with post-translational phage modification. Step-II: Discovery of peptide leads using phage-display. Step-III: Peptide synthesis, modification, labeling, conjugation to validate and optimize the lead.

Lausanne Area, Switzerland

Research Supervisor: Prof. Christian HeinisField of Research: Peptide, Protein Chemistry & Chemical BiologyPrime Goal of Research: To develop peptide macrocyles for potential therapeutic application.Project Features:• Design, synthesis and high throughput screening (HTS) of macrocyclic peptide/peptoid libraries against critical proteins (like MDM2) to discover high affinity ligands for vital protein-protein interaction inhibition.• Structure based molecule design, screening, hit identification, validation and lead optimization.• Hands-on expertise in using automated solid-phase synthesizer and ECHO acoustic dispenser for HTS of combinatorial libraries on Nano- to Micro-liter scale.• Biology domain: Got experience of bacterial cell culture, expression and purification of recombinant MDM2 protein.

Pohang, Gyeongsangbuk-Do, Korea

Research Supervisor: Prof Hyun Suk Lim [Initially I was joined as a Postdoc researcher in Prof Lim’s lab and then got promoted to Research Assistant Professor]Field of Research: Peptidomimetic, Organic Chemistry & Chemical BiologyPrime Goal of Research: To develop novel synthetic molecules that can modulate cellular signaling pathways with an emphasis on protein-protein interactions (PPIs). Project/Work Features: • Design, development and solid-solution phase synthesis of peptidomimetics/foldamers as modulators of protein-protein interaction towards drug discovery.• Synthesis of peptide based ‘Proteolytic Targeting Chimeras (PROTACs) as novel therapeutics.• Reviewed several journal articles, guided experimental techniques to graduate/undergraduate students.• Gained fundamental knowledge of biological techniques. I got hands on experience of cell culture (of Kasumi-1 cell lines) to grow the cells for 'cell permeability' experiment. Studied binding assay against AML1-ETO fusion protein.

Pohang, Gyeongsangbuk-Do, Korea

Research Supervisor: Prof Hyun Suk Lim.Field of Research: Peptidomimetic & Foldamer Chemistry, Organic Chemistry & Chemical BiologyPrime Goal of Research: To develop novel synthetic molecules that can modulate cellular signaling pathways with an emphasis on protein-protein interactions (PPIs). Project/Work Features: • Development of peptoid foldamers and their structural studies by NMR, CD or X-ray crystallography; Synthesis of α-helix mimetics to study inhibition of protein-protein interaction. • Solid-phase method development to construct PNA encoded libraries towards drug discovery.• Synthesis of peptide based ‘Proteolytic Targeting Chimeras (PROTACs) as novel therapeutics.• Worked on few collaborative projects, guided organic synthesis related experimental techniques to graduate/undergraduate students in the lab.

Gwangjin-Gu, Seoul, Korea

PhD major: Bioorganic Chemistry.Supervisor: Prof. Dongyeol LimSpecialization In – Peptide Chemistry and Organic Chemistry Thesis title: Solid-Phase Syntheses of Highly Methylated Cyclic Depsipeptides; Coibamide A, Triostin A, and Their Derivatives.Project/Work Features and Related Experience:• Synthesis of un-natural amino acid building blocks and intermediates.• Solid-phase synthesis and method development for the synthesis of sterically hindered cyclic peptides.• Synthesis of drug counterpart required to incorporate in ADCs. • Taught experimental section to undergraduate students for their course studies.

Pune, Maharashtra, India

Supervisor: Dr. Sujit GhoraiDepartment: R & D. Dept. Medicinal Chemistry and Drug Discovery.My Work Features:• Design, synthesis and optimization of analogues to support lead generation in drug discovery.• Design and synthesis building blocks/ key intermediates/scaffolds for focused libraries.• Multi-step synthesis from mg to gm scales, purification and characterization of molecules.

Doctor Of Philosophy - Phd, Bioorganic Chemistry, A+

Synthesis and Biological evaluation of highly methylated cyclic depsipeptides.

M.Sc., Organic Chemistry