Ganesh Sable Email & Phone Number

Pasadena, California, United States

Peptide and Protein engineering and conjugation chemistries towards 'peptide drug discovery'.

Edmonton, Alberta, Canada

Work on Peptide drug discovery which mainly includes: Macrocyclic Peptides, Radiolabeled-fluorescent labeled peptides, Phage-display peptide modifications, Conjugation chemistry, organic synthesis and medicinal chemistry.

Edmonton, Alberta, Canada

Research Supervisor: Prof. Ratmir DerdaField of Research: Peptide drug discovery, Phage-display post translational modification.Prime Goal of Research: Radio/Bio labeled Macrocyclic peptide drug discovery using phage-display technology.Project Features: Step-1: We establish the aqueous chemistry compatible with post-translational phage modification..

Lausanne Area, Switzerland

• Research Supervisor: Prof. Christian HeinisField of Research: Peptide, Protein Chemistry & Chemical BiologyPrime Goal of Research: To develop peptide macrocyles for potential therapeutic application.Project Features:
• Design, synthesis and high throughput screening (HTS) of macrocyclic peptide/peptoid libraries against critical proteins (like MDM2) to discover high affinity ligands for vital protein-protein interaction inhibition.
• Structure based molecule design, screening, hit identification, validation and lead optimization.
• Hands-on expertise in using automated solid-phase synthesizer and ECHO acoustic dispenser for HTS of combinatorial libraries on Nano- to Micro-liter scale.
• Biology domain: Got experience of bacterial cell culture, expression and purification of recombinant MDM2 protein.

Pohang, Gyeongsangbuk-do, Korea

• Research Supervisor: Prof Hyun Suk Lim [Initially I was joined as a Postdoc researcher in Prof Lim’s lab and then got promoted to Research Assistant Professor]Field of Research: Peptidomimetic, Organic Chemistry &.
• Design, development and solid-solution phase synthesis of peptidomimetics/foldamers as modulators of protein-protein interaction towards drug discovery.
• Synthesis of peptide based ‘Proteolytic Targeting Chimeras (PROTACs) as novel therapeutics.
• Reviewed several journal articles, guided experimental techniques to graduate/undergraduate students.
• Gained fundamental knowledge of biological techniques. I got hands on experience of cell culture (of Kasumi-1 cell lines) to grow the cells for 'cell permeability' experiment. Studied binding assay against AML1-ETO.

Pohang, Gyeongsangbuk-do, Korea

• Research Supervisor: Prof Hyun Suk Lim.Field of Research: Peptidomimetic & Foldamer Chemistry, Organic Chemistry & Chemical BiologyPrime Goal of Research: To develop novel synthetic molecules that can modulate cellular.
• Development of peptoid foldamers and their structural studies by NMR, CD or X-ray crystallography; Synthesis of α-helix mimetics to study inhibition of protein-protein interaction.
• Solid-phase method development to construct PNA encoded libraries towards drug discovery.
• Synthesis of peptide based ‘Proteolytic Targeting Chimeras (PROTACs) as novel therapeutics.
• Worked on few collaborative projects, guided organic synthesis related experimental techniques to graduate/undergraduate students in the lab.

Gwangjin-gu, Seoul, Korea

• PhD major: Bioorganic Chemistry.Supervisor: Prof. Dongyeol LimSpecialization In – Peptide Chemistry and Organic Chemistry Thesis title: Solid-Phase Syntheses of Highly Methylated Cyclic Depsipeptides; Coibamide A.
• Synthesis of un-natural amino acid building blocks and intermediates.
• Solid-phase synthesis and method development for the synthesis of sterically hindered cyclic peptides.
• Synthesis of drug counterpart required to incorporate in ADCs.
• Taught experimental section to undergraduate students for their course studies.

Pune, Maharashtra, India

• Supervisor: Dr. Sujit GhoraiDepartment: R & D. Dept. Medicinal Chemistry and Drug Discovery.My Work Features:
• Design, synthesis and optimization of analogues to support lead generation in drug discovery.
• Design and synthesis building blocks/ key intermediates/scaffolds for focused libraries.
• Multi-step synthesis from mg to gm scales, purification and characterization of molecules.

Doctor Of Philosophy - Phd, Bioorganic Chemistry, A+

Synthesis and Biological evaluation of highly methylated cyclic depsipeptides.

M.Sc., Organic Chemistry