Shore Lab, Faculty of Life Scienceshttp://paulshorelab.org/My main research studies the effect of CRISPR knock out, mutation and overexpression of CBFβ and its cofactors RUNX1/2 in human breast cancer cells with regard their migration, invasion and metastasis. Two manuscripts are currently in preparation from this work. I have also furthered my own research interests in hypoxia and cancer stem cells by developing new in vitro models with better potential to study the effects… Show more Shore Lab, Faculty of Life Scienceshttp://paulshorelab.org/My main research studies the effect of CRISPR knock out, mutation and overexpression of CBFβ and its cofactors RUNX1/2 in human breast cancer cells with regard their migration, invasion and metastasis. Two manuscripts are currently in preparation from this work. I have also furthered my own research interests in hypoxia and cancer stem cells by developing new in vitro models with better potential to study the effects HIF1-alpha in breast cancer. Show less

Breakthrough Breast Cancer Unit Rebecca Lamb, Hannah Harrison, Duncan L. Smith, Paul A. Townsend, Thomas Jackson, Bela Ozsvari, Ubaldo E. Martinez-Outschoorn, Richard G. Pestell, Anthony Howell, Michael P. Lisanti and Federica Sotgia (2015). Targeting tumor-initiating cells: Eliminating anabolic cancer stem cells with inhibitors of protein synthesis or by mimicking caloric restriction.Oncotarget, Advance PublicationsRebecca Lamb, Hannah Harrison, James Hulit, Duncan L… Show more Breakthrough Breast Cancer Unit Rebecca Lamb, Hannah Harrison, Duncan L. Smith, Paul A. Townsend, Thomas Jackson, Bela Ozsvari, Ubaldo E. Martinez-Outschoorn, Richard G. Pestell, Anthony Howell, Michael P. Lisanti and Federica Sotgia (2015). Targeting tumor-initiating cells: Eliminating anabolic cancer stem cells with inhibitors of protein synthesis or by mimicking caloric restriction.Oncotarget, Advance PublicationsRebecca Lamb, Hannah Harrison, James Hulit, Duncan L. Smith, Michael P. Lisanti and Federica Sotgia (2014). Mitochondria as new therapeutic targets for eradicating cancer stem cells: Quantitative proteomics and functional validation via MCT1/2 inhibition.Oncotarget, Vol. 5, No. 22McClements L, Yakkundi A, Papaspyropoulos A, Harrison H, Ablett MP, Jithesh PV, McKeen HD, Bennett R, Donley C, Kissenpfennig A, McIntosh S, McCarthy HO, O’Neill E, Clarke RB, and Robson T (2013). Targeting treatment resistant breast cancer stem cells with FKBPL and its peptide derivative, AD-01, via the CD44 pathway. Clinical Cancer Research. Jul 15;19(14) Harrison H, Rogerson L, Gregson H, Brennan KR, Clarke RB, Landberg G (2012). Contrasting hypoxic response of cancer stem cells is dependent on ER status of breast cancer. Published OnlineFirst December 17, 2012; doi: 10.1158/0008-5472.Cancer Research. Feb 15, 2013 73; 1420 Show less

Breast Biology Group, Paterson Institute for Cancer Researchhttp://www.cancer.manchester.ac.uk/archive/breastbiology/Harrison H, Simões BM, Rogerson L, Howell S, Landberg G and Clarke RB (2013). EGFR and Notch Pathways Mediate Systemic Oestrogen Signalling Effects on Breast Cancer Progenitor Cell Activity. Breast Cancer Research 15:R21 (8 March 2013)Shaw FL*, Harrison H*, Spence K, Ablett MP, Simões BM, Farnie G and Clarke RB (2012). A detailed mammosphere assay… Show more Breast Biology Group, Paterson Institute for Cancer Researchhttp://www.cancer.manchester.ac.uk/archive/breastbiology/Harrison H, Simões BM, Rogerson L, Howell S, Landberg G and Clarke RB (2013). EGFR and Notch Pathways Mediate Systemic Oestrogen Signalling Effects on Breast Cancer Progenitor Cell Activity. Breast Cancer Research 15:R21 (8 March 2013)Shaw FL*, Harrison H*, Spence K, Ablett MP, Simões BM, Farnie G and Clarke RB (2012). A detailed mammosphere assay protocol for the quantification of breast stem cell activity. Journal of Mammary Gland Biology and Neoplasia Online First™, 5 June 10.1007/s10911-012-9255-3Agur Z, Kirnasovsky OU, Gennadiy Wasserman LT, Harrison H, Lamb R and Clarke RB (2011). Experimental validation of mathematically predicted effects of Dickkopf-1 protein on breast cancer stem cell differentiation. PLOS one 6(9): e24225.Agur Z, Kogan Y, Levi L, Harrison H, Lamb R, Kirnasovsky OU, Clarke RB. (2010). Disruption of a Quorum Sensing mechanism triggers tumorigenesis: a simple discrete model corroborated by experiments in mammary cancer stem cells. Biol Direct. Apr 20;5(1):20.Harrison H, Farnie G, Howell SJ, Rock RE, Stylianou S, Brennan KR, Bundred NJ, Clarke RB (2010). Regulation of Breast Cancer Stem Cell Activity by Signalling through the Notch4 Receptor. Cancer Res: Jan 15;70(2):709-18 Show less

Warren M, Chung YJ, Howat W, Harrison H, McGinnisa R, Haoc X, McCafferty J, Fredrickson N, Bradley A, Morse III HC (2009). Irradiated Blm-deficient mice are a highly tumor prone model for analysis of a broad spectrum of hematologic malignancies. Leukaemia Research: Feb;34(2):210-20van der Weyden L, Arends MJ, Dovey OM, Harrison H, Lefebvre G, Conte N, Gergely FV, Bradley A and Adams DJ (2008). Loss of Rassf1a cooperates with ApcMin to accelerate intestinal tumourigenesis.… Show more Warren M, Chung YJ, Howat W, Harrison H, McGinnisa R, Haoc X, McCafferty J, Fredrickson N, Bradley A, Morse III HC (2009). Irradiated Blm-deficient mice are a highly tumor prone model for analysis of a broad spectrum of hematologic malignancies. Leukaemia Research: Feb;34(2):210-20van der Weyden L, Arends MJ, Dovey OM, Harrison H, Lefebvre G, Conte N, Gergely FV, Bradley A and Adams DJ (2008). Loss of Rassf1a cooperates with ApcMin to accelerate intestinal tumourigenesis. Oncogene; 27(32): 4503-8Chung YJ, Jonkers J, Kitson H, Fiegler H, Humphray S, Scott C, Hunt S, Yu Y, Nishijima I, Velds A, Holstege H, Carter N and Bradley A (2004). A whole-genome mouse BAC micro-array with 1-Mb resolution for analysis of DNA copy number changes by array comparative genomic hybridization. Genome Research; 14(1): 188-96 Show less