Dror Sever Email & Phone Number

Denmark

Key skills, tasks, and responsibilities:* Data and Information Scientist, working with multiple scientific and clinical databases, text mining platforms, and search engines.* Author of state-of-the-art Literature Search Protocols, Clinical Literature Reviews and Reports for Clinical Evaluation Reports (CER), for the entire Novo Nordisk medical device portfolio. Particularly: - Strategic planning of the deliverables and stakeholders. - Identify and define the clinical area for the state-of-the-art/ current knowledge. - Establish a non-biased, systematic search strategy for literature search protocols. - Selection, analysis and appraisal of clinical data.* Internal CER reviewer, focusing on clinical evidence, and clinical data through the entire document. * Process development: achieved and maintain MDR compliance of Literature Search Protocols and Clinical Literature Reviews and Reports.* Analysis and assessment of regulatory documents, guidelines and requirements such as MDR REGULATION (EU) 2017/745, MEDDEV 2.7/1 revision 4, IMDRF MDCE WG/N56FINAL:2019, MDCG-2019-9, MDCG 2020-1, -5, -6 & -13. ISO standards and more.* Briefing clinical and scientific data to Medical Doctors, Project Managers, Risk Managers and/or Researchers.* Business development activities as a team member of the Cell Therapy Innovation Team.

Copenhagen Area, Capital Region, Denmark

The main aim of my research is to study the cellular and molecular responses of pancreatic progenitor cells at different time points following cellular ablation. During the last two years, I mentored a MD-PhD student who developed a human 3D system to study the role of GLIS3 in pancreatic development, and supervised a MSc student who studied the recovery process of the pancreas.* Additional interdisciplinary collaboration projects:• Regulation of calcium signaling, cellular maturation and function of β-cells by non-canonical Wnt signaling. • Using in silico modeling, and whole mount pancreatic sample 3D Image analysis, we demonstrated that the process of pancreatic network development can be deconstructed into two simple rules. An early stage of the network, characterized by redundant duct connection as new microlumens form, and a later transition is attributed to pruning of the network based on the flux of fluid running through the pancreatic network into the duodenum.• The in vivo role of the neuronal transcription factor REST in endocrine differentiation during pancreas development.The main achievements from my training in DanStem are:• Further developed as an expert within the field of translational diabetes research. • Involved in successful scientific collaborations.• Authored six scientific papers, one review, and successful grand proposal.• Implemented and optimized a multiphoton microscope bioimaging and laser ablation.• Formulated of DaPA's organization's mission statement and pillars• Successfully communicate and negotiated with management to purchase additional confocal microscope, and to add additional training programs for postdocs.

Copenhagen Area, Capital Region, Denmark

The aim of my research was to study pancreas development and regeneration in-vivo, in order to identify novel regulatory pathways involved in pancreatic progenitor expansion and differentiation. The overall goal of the study was to improve in-vitro pancreas-progenitor differentiation protocol, by activating these pathways. Hard scientific skills: - IHC & Bioimage acquisition (2D, 3D & 4D) using confocal and multiphoton microscopy. - Image analysis using FIJI, Imaris and Huygens software.- Sample collection and processing from embryonic and adult mice.- Pancreatic organoid system as a model for drug screening. - Cell culture and transfections of immortalized and primary cell lines and tissue explants.- Traditional and modern cloning techniques, including BAC recombineering, Crispr-Cas9, TOPO and seamless cloning.- Genotyping and gene expression using PCR and RT-PCR.- Fixed single cell staining with up to 9 different colors followed by fluorescence-activated cell sorting (FACS); - Bulk-mRMA library preparation and integrity assessment using fragment analyzer.- Multiplexing and bulk-mRNA sequencing. - Sample preparation and multiplexing for single cell RNA-seq (10x genomics, collaboration). Responsibilities as a DDA postdoc fellow:- To attend their DDA's annual meetings, initiatives and activities (2-3 per year). - To disseminate my scientific achievements in scientific meetings (1-2 per year). - To facilitate scientific discussions as a panel member or chairperson in international and local scientific meetings (1-2 per year). - To submit annual report with tracking and follow-up on milestones.

The Hebrew University, Hadassah Ein Karem Campus

• Cell Physiology course description: Physiology of excitable tissues, nerve, muscle, contractility and synaptic transmission.• Systems Physiology course description: The physiology of a number of systems in the healthy human body, and specifically emphasizing the integration between them: the cardiovascular, the respiratory, thermoregulation, the renal and the digestive systems.

Faculty Of Medicine, The Hebrew University, Jerusalem, Israel.

My Ph.D. research aim was to generate beta-cells exhibiting resistance to autoimmune destruction or with prolonged islet graft survival at various stages of Type 1 diabetes onset. My hypothesis was that inhibiting the transcription factor NF-kB, selectively in beta-cells, will protect them from the apoptotic signals induced by pro-inflammatory cues induced by autoreactive T lymphocytes.* Additional collaboration projects:• The involvement of the cell-surface glycoprotein, and mesenchymal marker CD44 in the autoimmune process, at different time points during the onset of type 1 diabetes.• Using an pancreatic islet transplantation model, we demonstrated that inhibition of the proinflammatory transcription factor NF-kB, has a protective effect on allogeneic pancreatic islet graft survival.• Involvement of thioredoxin-interacting protein (TXNIP) in glucocorticoid-mediated beta cell death.

Jerusalem, Israel

Contributed to successfully complete safety and pharmacodynamics phase I of an oral insulin pill.

Jerusalem, Israel

Laboratory Practice in Biochemistry for 2nd year biology students.

Hadassah University Hospital, Ein Karem Jerusalem

Phd Candidate, Biochemistry And Endocrinolgy

Master Of Science (Msc), Medical Scientist And Endocrinology, 94.72

Bachelor Of Medical Science (Ba.Med), Medicine, 90.3

Computer Engineering