Computer Aided Drug Design (CADD) and synthesis of New Chemical Entities (NCEs) targeting Mycobacterial Enoyl Acyl Carrier protein Reductase (ENR) enzyme.In Vitro anti tubercular assays, cytotoxicity/hepatotoxicity screening, Determination of solubility, log P, pKa, protein binding, human liver microsome stability and permeability of the synthesized NCEs.QSAR and QPAR study.

Synthesis of novel compounds directed towards drug candidates for various therapeutic targets.Synthetic planning and conducting multi-step organic reactions to prepare New Chemical Entities, their enantiomers, salts, prodrugs, amorphous forms and Standard compounds in Discovery scale with the total consideration of IPR issues. Conducting Optical resolution, Asymmetric synthesis, Organometallic and dissolving metal catalyzed reactions, High pressure and Low temperature reactions for the… Show more Synthesis of novel compounds directed towards drug candidates for various therapeutic targets.Synthetic planning and conducting multi-step organic reactions to prepare New Chemical Entities, their enantiomers, salts, prodrugs, amorphous forms and Standard compounds in Discovery scale with the total consideration of IPR issues. Conducting Optical resolution, Asymmetric synthesis, Organometallic and dissolving metal catalyzed reactions, High pressure and Low temperature reactions for the preparation of organic compounds. Improving the pharmacodynamic and pharmacokinetic profile of compounds by implementing various medicinal chemistry strategies. Establishing structure-activity relationships using bioinformatics, biological and DMPK data.Patent drafting. Show less

Synthesis of novel compounds directed towards drug candidates for various therapeutic targets.Synthetic planning and conducting multi-step organic reactions to prepare New Chemical Entities, their enantiomers, salts, prodrugs, amorphous forms and Standard compounds in Discovery scale with the total consideration of IPR issues. Conducting optical resolution, asymmetric synthesis, organometallic and dissolving metal catalyzed reactions, high pressure and low temperature reactions for the… Show more Synthesis of novel compounds directed towards drug candidates for various therapeutic targets.Synthetic planning and conducting multi-step organic reactions to prepare New Chemical Entities, their enantiomers, salts, prodrugs, amorphous forms and Standard compounds in Discovery scale with the total consideration of IPR issues. Conducting optical resolution, asymmetric synthesis, organometallic and dissolving metal catalyzed reactions, high pressure and low temperature reactions for the preparation of organic compounds. Show less

Teaching Advanced Pharmaceutical Chemistry and Spectroscopy to B.Pharm students.