Dennis Solas Email and Phone Number
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Excellent Synthetic Organic Chemist with 15+ years experience in Small Molecule Synthesis, Drug Discovery, Pro-drug Modification along with work in peptide and DNA synthesis as well as Medicinal Chemistry and Polymer Chemistry.Interested in companies that could make use of my strong organic chemistry background. Strengths have involved being instrumental in taking 4 startup companies from basic concept to solid Research and Development as well as medical product based businesses employing in all cases inventive, new and novel technologies. • Successfully devised and carried out scale-up synthesis (gram to multigram) of several drug metabolites and API impurities to support pre-IND and NDA clinical trials for in-house analytical department • Developed novel chemical techniques(modified nucleosides/nucleotides)/surface chemistry/ fluorescent labeling to create spatially located DNA libraries on glass surfaces leading to the foundation of Affymetrix • Developed new and novel formulations of drugs to improve deliverability for devices based on inhalation • Designed and optimized novel(and existing) synthetic processes as well as their reports for outside clinical studies • Successfully generated new and novel chelating fluorophores for pulsed fluorescence immunoassaysSpecialties: • Large and small scale organic syntheses at the bench with expertise in developing procedures and required analytical background • HTS Analysis and Progression• Iontophoretic Transdermal Delivery (Charged Pro Drugs) for use in skin patch technology• Medicinal Chemistry• Assay/Immunoassay kit development including Protein/Antibody Modifications• Energetic Formulations for creating Drug Aerosols for Pulmonary Delivery
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Senior Scientist IiiProsetta Biosciences IncSan Francisco, Ca, Us
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Senior Scientist IiiProsetta Biosciences Inc Sep 2012 - PresentSan Francisco, California, Us• Conducted drug discovery and synthesis of new and novel small heterocyclic molecules for use as antiviral drugs with special emphasis on HIV, ALS as well as Antimicrobials /Antibacterials. This work also included SAR around lead compounds.• Developed a new synthetic approach for producing unsymmetrical phenothiazinium compounds found to have activity in several disease states.• Discovered nitrogen based heterocyclic dimers useful against several forms of cancer and the chemistry used to produce them. -
Senior ScientistCalera Corporation 2011 - 2012Investigated new and novel ways of sequestering CO2 for the production of organic/inorganic compounds.
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Contract ScientistAlexza Pharmaceuticals Mar 2009 - Mar 2011Fremont, California, Us•Scaled up and synthesized multigram quantities of bioactive small organic compounds for use in upcoming clinical studies in connection with the analytical group.•Successfully worked with PK/ADME group and analytical development to identify impurities and degradants ( via HPLC,LC/MS, NMR, IR etc.) in APIs and drug products as well as their synthesis. Such work on low level impurities dealing with Fentanyl resulted in a recent publication. •Conducted in silico toxicity assessments (DEREK), and synthesized impurities and degradants for use as standards and for in vitro genetox studies.•Participated in discussions with API CROs on steps to reduce impurities caused by intermediates i.e. dimer formation and contaminated starting materials. -
Sr. Scientist IiAlexza Pharmaceuticals Aug 2001 - Feb 2009Fremont, California, UsPrimarily involved with organic synthesis of drug and drug like compounds as well as investigation of novel drug delivery methods through vaporization to generate aerosols for inhalation. Other research areas include :• Generated thermally reversible prodrugs of target drug molecules allowing for the volatilization of heat sensitive compounds• Synthesized metabolites and thermal degradents (labeled and non-labeled forms i.e. Deuterium and 13C) of target drugs in house resulting in saving +$100,000 for the company by avoiding the use of outside contract labs• Investigated and formulated various ignition mixtures for the initiation of fuels employed in drug volatilization resulting in the current inexpensive device design• Successfully demonstrated novel methods for initiation of a large variety of thermitic fuel mixtures in drug heating platform resulting in reusable and environmentally friendly drug delivery devices • Synthesized over 10 drugs, otherwise unobtainable, for vaporization studies resulting in expansion of the company’s deliverable drug portfolio
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Sr ScientistAffymax Research Institute 1991 - 2001Pro-drug modifications and Combinatorial library synthesis. Included:• Modification of small to intermediate size molecules with multiple guanidines to effect transport across cell membranes • Synthesize 100 charged prodrugs for use in transdermal prodrug electrotransport in collaboration with Alza to further both companies drug pipeline• Developed 5’- modified nucleosides (photoactivatable protecting groups at the 5’ position) and the chemistry required for use in the synthesis of “DNA on chips” leading to the spin off company Affymetrix• Synthesized new and novel photoprotecting groups for alcohols, amines, thiols, phenol and carboxylic acids leading to commercialization of same• Adapted membrane technology and glass surfaces for the synthesis of peptides and small organic molecules using photolithography (VLSIPS technology) which vastly accelerated the company’s drug discovery via combinatorial synthesis
Dennis Solas Skills
Dennis Solas Education Details
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Purdue UniversityOrganic Chemistry -
University Of Missouri-Kansas CityChemistry
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Palo Alto:Syntex LabsOrganic Chemistry / Synthetic Methodology
Frequently Asked Questions about Dennis Solas
What company does Dennis Solas work for?
Dennis Solas works for Prosetta Biosciences Inc
What is Dennis Solas's role at the current company?
Dennis Solas's current role is Senior Scientist III.
What is Dennis Solas's email address?
Dennis Solas's email address is ds****@****xza.com
What is Dennis Solas's direct phone number?
Dennis Solas's direct phone number is 1-415-334*****
What schools did Dennis Solas attend?
Dennis Solas attended Purdue University, University Of Missouri-Kansas City, Palo Alto:syntex Labs.
What skills is Dennis Solas known for?
Dennis Solas has skills like Drug Discovery, Hplc, Lc Ms, Chemistry, R&d, Analytical Chemistry, Nmr, Organic Synthesis, Organic Chemistry, Biotechnology, Formulation, Medicinal Chemistry.
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