David Williamson Email and Phone Number
Seattle, WA, US
David Williamson's Location
Seattle, Washington, United States, United States
David Williamson's Contact Details
David Williamson work email
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About David Williamson
Bioinformatics scientist and molecular biologist with 24 years experience developing clinical diagnostics and computational workflows in the immunology and oncology genomic spaces. 17 peer reviewed scientific publications.
David Williamson's Current Company Details
Strand Life Sciences
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Senior Director - Bioinformatics Solutions
Seattle, WA, US
- Website:
- strandls.com
- Employees:
- 617
David Williamson Work Experience Details
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Senior Director - Bioinformatics SolutionsStrand Life SciencesSeattle, Wa, Us
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Senior Director - Bioinformatics Solutions (Sme)Strand Life Sciences Sep 2024 - PresentBangalore, Karnataka, In
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Director Of Production BioinformaticsTwinstrand Biosciences Jan 2024 - May 2024Designed and developed NGS bioinformatics workflows and reporting systems to detect and monitor AML blood cancer using DuplexSeq, and Nextflow on AWS. Developed clinical laboratory systems in preparation for regulatory compliance.Lead team of production bioinformatics software engineers. -
Sabbatical (18 Months, Self-Imposed) - Parenting And Music StudyHome Jul 2022 - Dec 2023Studied piano and guitar.Parenting.
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Director - Bioinformatics ServicesAdaptive Biotechnologies Corp. Mar 2012 - Jun 2022Seattle, Wa, UsDesigned primary bioinformatics workflow algorithm.Engineered CLIA approved bioinformatics pipeline to process clinical NGS diagnostic immunoassays (TCRA, TCRB, TCRG, IgH, IGK/L), ImmunoSeq.Established CLIA approved reporting system for identifying and tracking clones of interest in TCell and BCell cancers (MRD - monitoring minimum residual disease), ClonoSEQ.Established quality control systems for monitoring and improving the productivity of NGS workflows.Developed normalization methods to control for artifacts of multiplex PCR amplification.Verification and Validation, developed and supported customer facing analytical platform, ImmunoSeq.Managed tier 3 support for customer services.Managed all production and RandD data sets.Managed small bioinformatics team. -
Sr. Bioinformatics ScientistIllumina Aug 2011 - Feb 2012San Diego, Ca, UsLead the bioinformatics development for the TruSeq whole exome and custom targeted enrichment capture technologies.Conducted a 9 month pilot study as the primary analyst for Pfizer, identifying and annotating somatic mutations from the exomes of 23 pairs of tumor/normal samples using Agilent SureSelect enrichment technologies, materializing a multimillion dollar WGS services contract with Pfizer for Illumina.Worked with marketing to define custom enrichment and custom amplicon product specifications.Developed and validated the TruSeq custom enrichment and MiSeq custom amplicon oligo probe multiplex assays.Developed and validated targeted sequencing coverage analysis workflow.Produced a comparative analysis of custom enrichment technologies (Raindance, Roche, NimbleGen, Agilent SureSelect, Illumina TruSeq).Supported the sales and marketing teams as a customer facing bioinformatics expert.Developed technical competitive marketing materials.Trained sales and marketing teams on technical aspects pertaining custom enrichment assay design and analysis.Developed DNA/RNA NGS workflow and QC validation.Automated the detection and annotation of SNPs, Indels, somatic mutations, and structural variation detection in tumor/normal pairs (cancer).Automated the detection of differentially expressed genes using RNASeq.Presented seminars at webinars, and both national and international conferences. -
Bioinformatics Scientist 2Illumina Dec 2009 - Aug 2011San Diego, Ca, Us
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Bioinformatics Project Manager For Sequencing ServicesIllumina May 2008 - Dec 2009San Diego, Ca, UsDeveloped DNASeq/RNASeq/ChIPSeq and exome capture workflows including sequence alignment, polymorphism detection, genome visualization, RNA fusion transcript discovery, and small bacterial genome de novo assembly.Improved the robustness and biological relevance of early access software by critically evaluating beta versions, identifying and documenting bugs, and suggesting fixes and feature requests.Managed the transfer and archiving of large volume data sets over a multisite network.Presented analytical methods, and finalized resultant data to service customers to promote sales.Planned CLIA lab development.
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Ucsf Graduate Student In Biological Medical InformaticsThe J. David Gladstone Institutes Sep 2003 - Mar 2008San Francisco, California, UsPh.D. DissertationGenetic and Bioinformatic Approaches to Identify Polymorphic Modulators of Transcription Factor Binding and Disease Phenotypes Including HIV1 Viremia.Genetic Survey - To conduct a genetic survey of four genes (CCR5, TLR9, IRF5, APOE) in order to identify associations between genotype/haplotype frequencies and viremia levels, in a population of HIV positive Americans primarily derived from the San Francisco SCOPE cohort.Computational Survey - To computationally survey the database of human single nucleotide polymorphisms (SNPs) in order to identify and rank prioritize which polymorphisms are likely to have allele-specific transcription factor recruitment. Transcription factor binding site matrices provided by the BIOBASE TRANSFAC database are pattern matched against human genome sequence to derive quantitative scores reflecting allele-specific transcription factor binding affinity.Software Development (Delta-MATCH) - To produce a user friendly, web-based tool (Delta-MATCH). Predictions made by the computational survey also integrate data from a broad number of external bioinformatics resources (UCSC human genome, dbSNP, HAPMAP, Gene Ontology, Affymetrix, Illumina, Perlegen, PReMod), and are used to identify important candidate SNPs that may be genotyped and further investigated for association with inheritable disease.Polymorphism Selection - To produce discrete lists of high-value candidate single nucleotide polymorphisms (SNPs) to investigate the following disease phenotypes: cardiovascular disease, obesity, dyslipidemia, diabetes mellitus, multiple sclerosis, autoimmunity, prostate cancer, glioma, and Alzheimer’s disease. These candidate SNPs are being genotyped in the appropriate genetic cohorts through collaborations at UCSF. -
Research Associate IiJ. David Gladstone Institutes Mar 2001 - Mar 2008Conducted genotype/haplotype association studies.Investigated more than 130 polymorphisms in candidate genes (ApoE, LIPC, CETP, MTP, APM1, FABP2, AKAP10, TLR9, CCR5, IRF5) for association with disease phenotypes: dyslipidemia, cardiovascular disease, insulin resistance, obesity, the metabolic syndrome, Tcell activation, and HIV-1 viremia/progression.Designed polymorphism detection assays and genotyped more than 80,000 single nucleotide polymorphisms (SNPs) using Restriction Fragment Length Polymorphism (RFLP), Allele Specific Oligo (ASO) hybridization, High-Performance Liquid Chromatography (HPLC), and Taqman assays.Conducted genetic analyses (case/control, pedigree, TDT inheritance, linkage).Primer design, PCR, sequencing, array analysis (Illumina and Affymetrix arrays).Database curator for the Turkish Heart Study (THS) (> 12,000 biological samples).Validated predicted gene associations using advanced techniques in molecular biology.Engineered a transgenic mouse strain overexpressing human protein disulfide isomerase.Developed a Dual-LuciferaseTM Reporter (DLR) promoter expression assay.Evaluated the affect of polymorphisms on protein function using 3-D modeling.
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Pharmaceutical Chemistry / Pharmacology Pc122 Teacher'S AssistantUcsf Graduate School Of Pharmacy Sep 2004 - Mar 2005San Francisco, California, UsAdministrated and graded exams for 80+ PharmD students.Digitally recorded, distributed and archived digitizer lecture materials. -
Research Technician IFred Hutchinson Cancer Research Center Mar 1999 - Aug 2000Seattle, Wa, UsCurated colonies of eight lines of knockout mice.Investigated tumorigenesis in tumor suppressor knockout mouse models.PCR genotyping. -
United States Peace Corps Volunteer, Gabon, Central AfricaU.S. Peace Corps May 1995 - Nov 1997Washington, District Of Columbia, UsConstructed sustainable fresh water fisheries and integrated agricultural farming systems.Combatted the spread of HIV/AIDS by hosting educational seminars.Ambassador to the Peace Corps mission.Generated positive change.
David Williamson Skills
Genomics
Bioinformatics
Genetics
Sequencing
Dna Sequencing
Molecular Biology
Protein Chemistry
Pcr
Assay Development
Biochemistry
Genotyping
Biotechnology
Statistics
Systems Biology
David Williamson Education Details
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University Of California, San FranciscoBiological And Medical Informatics -
San Francisco State UniversityEcology And Systematic Biology
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Western Washington UniversityCellular & Molecular Biology
Frequently Asked Questions about David Williamson
What company does David Williamson work for?
David Williamson works for Strand Life Sciences
What is David Williamson's role at the current company?
David Williamson's current role is Senior Director - Bioinformatics Solutions.
What is David Williamson's email address?
David Williamson's email address is da****@****ate.com
What is David Williamson's direct phone number?
David Williamson's direct phone number is +120665*****
What schools did David Williamson attend?
David Williamson attended University Of California, San Francisco, San Francisco State University, Western Washington University.
What skills is David Williamson known for?
David Williamson has skills like Genomics, Bioinformatics, Genetics, Sequencing, Dna Sequencing, Molecular Biology, Protein Chemistry, Pcr, Assay Development, Biochemistry, Genotyping, Biotechnology.
Who are David Williamson's colleagues?
David Williamson's colleagues are Ramesh S, Anurag Harsha, Nikhin Joseph George, Kiran Thulasidas, Chaitanyaraj Jadeja, Iki Oko, Bharat Ramamurthy.
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