My primary interests are focussed on understanding the role played by glutamate in mediating behavioral changes induced by immune activation. My current research efforts have demonstrated that immune activation leads to increases in glutamate concentration in subcortical brain regions which in turn bears strong correlations to behavioral symptoms. I believe that modeling the mechanisms by which inflammation engages glutamate neurotransmission would help in identifying more precise targets in the glutamate pathway which in turn could lead to new treatments. A major limitation in translational efforts has been our inability to differentiate the physiological from the pathological alterations in glutamate signaling. Immune mediated changes in glutamate neurotransmission might provide us with a useful platform to understand these differences and better exploit them for new drug developments.