Eileen Higham Email and Phone Number
United States
Eileen Higham's Location
United States, United States
Eileen Higham's Contact Details
Eileen Higham work email
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About Eileen Higham
Passionate executive leader with over 20 years of experience driving transformative innovations in cell, virus, and protein-based therapies to improve global health. A proven track record of harnessing deep technical, strategic, and operational acumen to accelerate the delivery of breakthrough treatments that redefine clinical outcomes. Passionate about building world-class organizations and pioneering next-generation cell and gene therapies that revolutionize treatment paradigms. Education includes a BSE from Princeton University and a PhD from MIT.
Eileen Higham's Current Company Details
Eileen Higham Work Experience Details
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Co-Founder And Chief Executive OfficerMetriq HealthUnited States
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MemberChief Jun 2023 - PresentNew York, Ny, Us
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Chief Technology OfficerSastra Cell Therapy May 2023 - PresentSouth San Francisco , Ca, Us -
Scientific Advisory Board MemberXcell Biosciences Feb 2023 - PresentSan Francisco, California, Us -
Scientific Advisory Board MemberAcepodia Apr 2021 - PresentAlameda, California, Us -
Senior Vice President, Head Of Technical OperationsIntergalactic Therapeutics May 2020 - Mar 2023Cambridge, Ma, Us -
Vice President, Head Of Analytical & Process DevelopmentSana Biotechnology, Inc. Dec 2018 - Mar 2020Seattle, Washington, Us -
Senior Director, Analytical & Process DevelopmentJuno Therapeutics, Inc. Aug 2017 - Dec 2018Provide strategic, scientific, and technical leadership for development of best-in-class manufacturing processes and analytical packages for production of engineered T cell therapies, including:• Building and leading an organization of 100+ people, composed of 5 highly successful, multi-level departments of scientists and engineers. • Developing and managing budgets, resources, business processes• Developing strategies to enable well-controlled and well-characterized drug product process design and associated analytical packages to support Phase 0 through commercialization• Leading high impact cross-functional interactions with internal and external stakeholders to enable seamless integration of new technologies, manufacturing platforms, and analytical methods; including collaborative interfaces with Research, Clinical, Regulatory Affairs, Technology Strategy & Innovation, Technical Operations, Commercial, Legal, Business Development, academic founders, and external partners• Providing advice to executive leadership on technology transactions and business development opportunities to support development of next generation engineered T cell therapies
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Senior Director, Process DevelopmentJuno Therapeutics, Inc. Jun 2016 - Aug 2017Provide strategic, scientific and technical leadership for development of best-in-class manufacturing processes for production of engineered T cell therapies, including: • Building and leading a highly successful, multi-level department of scientists and engineers• Developing strategy to enable rapid experimental medicine (Phase 0) and first-in-human (Phase 1) Drug Product process design• Developing strategy to enable well-controlled and well-characterized Phase 2+ Drug Product process design• Leading cross-functional interactions with internal and external stakeholders to enable seamless integration of new processes and technologies, including successful interfaces with Research, Clinical, Regulatory Affairs, Technical Research & Development, Technical Operations and external partners• Providing advice to senior leadership on technology transactions to support manufacturing process development for engineered T cell therapies
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Director, Platform & Early Process DevelopmentJuno Therapeutics, Inc. Jan 2016 - Jun 2016Provide strategic, scientific and technical leadership for development of best-in-class manufacturing processes for production of engineered T cell therapies, including: • Building and leading a highly successful, multi-level team of scientists and engineers• Developing a strategic technology roadmap and leading associated external collaborations and internal technology development efforts• Leading cross-functional interactions across Juno, including with Research, Clinical, Regulatory Affairs, Intellectual Property and Business Development, to enable effective and efficient integration of new technologies• Developing process development strategies to enable experimental medicine (Phase 0) and first-in-human (FIH) clinical programs• Providing advice to senior management on technology transactions to support manufacturing process development for engineered T cell therapies
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Associate Director / Product Development Team Leader, Adoptive Cellular TherapyMedimmune Feb 2015 - Jan 2016Gaithersburg, Maryland, Us• Enable and accelerate MedImmune’s entry into Adoptive Cellular Therapy (ACT) through joint appointments in the Oncology iMED and Biopharmaceutical Development.• As a strategic leader in the Oncology iMED, responsible for oncologic applications of ACT and integrating ACT into the broader context of the MedImmune/AstraZeneca Oncology portfolio. - Develop strategic vision for ACT at MedImmune, including engineered T cell therapies (CAR-T, TCR-T and TIL therapies). - Develop detailed plan to implement strategy and gain senior governance approval. - Identify internal and external resources required to successfully execute plan, including human, intellectual property and financial resources. - Lead a successful cross-functional team consisting of Research, Biopharmaceutical Development, Translational, Clinical, Commercial, Regulatory, Finance and Partnering & Strategy representatives to support ACT vision.• As a scientific leader in Biopharmaceutical Development, responsible for leading a technical team to develop next generation manufacturing solutions to enable and accelerate delivery of novel cellular therapies to the clinic, including both autologous and allogeneic therapies. - Identify and develop emerging technologies to build the product and process understanding required to enable commercialization and successful regulatory approval of cellular therapies. -
Senior ScientistMedimmune Aug 2013 - Feb 2015Gaithersburg, Maryland, UsCell Culture & Fermentation Sciences, Biopharmaceutical DevelopmentPrimary responsibilities:• Develop new technologies, processes and parental cell lines to accelerate the generation of high-yielding, stable mammalian clones expressing therapeutic proteins. Through this work, decreased the cell line development timeline by 20-30%.• Lead cell line development campaigns to generate high-yielding, stable mammalian clones expressing therapeutic proteins.• Serve as Upstream lead on multiple cross-functional CMC teams to enable successful pipeline progression.• Lead a flow cytometry subteam developing novel assays to predict process performance and/or phenotypic stability.• Research and evaluate potential business development opportunities for cellular immunotherapies, viral vaccines and/or therapies.• Manage a group of up to three associate scientists.
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Scientist IiMedimmune May 2010 - Aug 2013Gaithersburg, Maryland, UsCell Culture & Fermentation Sciences, Biopharmaceutical Development
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Graduate Student / Postdoctoral FellowMassachusetts Institute Of Technology (Mit) Aug 2004 - May 2010Cambridge, Ma, UsDepartment of Biological EngineeringKoch Institute for Integrative Cancer Research• Demonstrated that both naïve and effector T cells are rapidly tolerized in the tumor environment of a spontaneous prostate cancer model.• Evaluated potential mechanisms of tumor-induced tolerance, and demonstrated that tolerization mediated by regulatory dendritic cells is the critical mechanism in this model.• Developed two novel localized immunotherapeutic approaches to delay and/or reverse the tolerization of T cells in the tumor environment: 1. Using a retrovirus, engineered tumor-reactive T cells to express CD40 ligand to mature dendritic cells in the tumor environment. 2. Surgically delivered ex vivo matured, antigen-loaded dendritic cells into the tumor tissue to offset endogenous suppressive dendritic cells. -
Graduate Resident TutorMassachusetts Institute Of Technology (Mit) Aug 2005 - Apr 2010Cambridge, Ma, Us• Mentored approximately 60 undergraduate students per year to aid in academic achievement, personal growth, managing stress and fostering personal and professional relationships.
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Biochemical EngineerMerck Jul 2001 - Jul 2004Rahway, New Jersey, UsMerck Research LaboratoriesPrimary responsibilities:• Led focused research effort to develop an in-house, serum-free cell culture medium for use in the efficient large-scale production of a candidate vaccine. • Developed a High Temperature, Short Time (HTST) barrier to reduce the risk of viral contamination in bioreactors. -
InternMerck Jun 2000 - Aug 2000Rahway, New Jersey, UsVaccine Technology & Engineering, Merck Manufacturing Division• Determined the critical physical parameters which significantly affect the stability of the varicella bulk product used in the production of a varicella vaccine.
Eileen Higham Skills
Cell
Flow Cytometry
Molecular Biology
Immunology
Biochemistry
Vaccines
Technology Transfer
Mammalian Cell Culture
Cell Biology
Immunoassays
Oncology
Assay Development
Drug Discovery
Upstream Bioprocess Development
Cell Line Development
High Throughput Screening
Media Optimization
Immune Cell Engineering
Viral Vector Design And Amplification
Htst Technology Development
Isolation And Propagation Of Primary T Cells And Dendritic Cells
In Vivo Experiments With Murine Models
Vaccine Research And Development
Eileen Higham Education Details
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Massachusetts Institute Of TechnologyBiological Engineering -
Princeton UniversityEngineering Biology
Frequently Asked Questions about Eileen Higham
What company does Eileen Higham work for?
Eileen Higham works for Metriq Health
What is Eileen Higham's role at the current company?
Eileen Higham's current role is Co-Founder and Chief Executive Officer.
What is Eileen Higham's email address?
Eileen Higham's email address is hi****@****une.com
What is Eileen Higham's direct phone number?
Eileen Higham's direct phone number is +130139*****
What schools did Eileen Higham attend?
Eileen Higham attended Massachusetts Institute Of Technology, Princeton University.
What skills is Eileen Higham known for?
Eileen Higham has skills like Cell, Flow Cytometry, Molecular Biology, Immunology, Biochemistry, Vaccines, Technology Transfer, Mammalian Cell Culture, Cell Biology, Immunoassays, Oncology, Assay Development.
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