Eivgeni Mashin Email & Phone Number

Cambridge, Massachusetts, United States

- Supported Biology groups with LC-MS/MS method development, bio-analysis and characterization of the major metabolites of compounds in cell lysate in effort to understand the cell death mechanism (Agilent QTOF 6545).-Analyzed and interpreted in vitro data and performed in vitro-in vivo correlations that helped nominate several compounds for pre-clinical development.-Applied PBPK modeling using GastroPlus software to predict pharmacokinetics of compounds in discovery and development.-Coordinated preclinical studies outsourced to CROs.

Cambridge, Ma

Designed and implemented novel assay to detect bacterial drug metabolism using LC/MS instruments.Executed microbial and biochemical assays to support the company’s platform and preclinical programs.Analyzed, interpreted and communicated data internally, as well as advised follow up experiments to program teams along with preparing technical reports.Served as a technical resource for junior staff and leveraged expertise in laboratory technology as a functional resource/trainer.

Beverly, Ma

Designed syntheses of radiolabeled novel bifunctional nitric oxide donor and redox degradation catalyst in milligram to gram quantities followed by analysis with LC/MS, HPLCDeveloped cost-efficient and scalable chemical processes for the synthesis of nitric oxide prodrugs.Screened and identified safer and greener reagents for performing key transformations in the synthesis of drug candidates.Determined metabolic profiles and identified metabolites by LC/MS-QTOF analyzing in vitro incubation and in vivo study samples.Performed syntheses of metabolites; structural ID by NMR and MS. Conducted, interpreted and reported on studies that supported discovery and preclinical drug development; Developed analytical methods to analyze samples; Performed plasma stability studies; Studied drug interactions; Designed protocols, evaluated data, and wrote technical reports; Maintained instrument calibrations; Trained new employees.Assessed radiolabeled compounds for stability and purity; Developed HPLC methods and analyzed plasma samples; Interpreted and reviewed chromatography data; Presented results at meetings and internal expositions.Developed and optimized sensitive and reliable LC-MS assays for PK studies. provide technical support to other bioanalytical teams and provided update to project teams and line management.Provide LC-MS and analysis for small molecules for medicinal chemist.Managed several bioanalytical assay development projects such as Phloroglucinol fatty acid synthase inhibitor, Resolvin E1 and Cannabinoid.Developed and Completed 3 preclinical assay for quantification of Prostaglandin E2, Resolvin E1, cyclic GMP, in rat and monkey plasma.

Haifa Area, Israel

Course: General ChemistryTaught and explained theoretical background followed by problem sets in front of class of 30 students. Assisted with writing problem sets and final exam questions. Guided students individually with homework problems and further material explanations.Course: Principles of Chemistry LaboratorySupervised, instructed and trained students in general laboratory skills and techniques. Emphasized keeping complete and accurate scientific notes along with guidance for writing a scientific report.Prepared students for a theoretical background in upcoming experiments.

Haifa, Israel

Maintained and operated weapons and armory for the I.N.S. Independence ship. Manager of weapon and armory division and commander of more than 10 soldiers.

Master’S Degree, Organic And Inorganic Chemistry, 3.94

Activities and Societies: Thesis title: Synthesis via Si-H activation and Characterization of Intramolecular Amino-Stabilized Silyllithium.

Bachelor’S Degree, Chemistry, 3.85

Undergraduate Research Assistant, Technion - Israel Institute of Technology. Adviser: Professor Yitzhak Apeloig - Studied reactions.