Eleanor Howe Email and Phone Number
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Founder and CEO of Diamond Age Data Science. Computational biologist and data scientist with broad experience in using genomics data to inform drug discovery, target identification, target validation, and model selection. Background in drug-discovery projects in oncology, cardiovascular disease and rare diseases. Past work includes:* RNA-Seq analysis, both single-cell and bulk, including QC/Normalization, differential expression and pathway analysis. Used for purposes of compound mechanism-of-action studies, discovery biology, biomarker discovery. * Functional assay or dropout screen (e.g. Project Achilles) data analysis. * Data visualization, including building interactive tools for exploring large datasets or the results of a complex analysis. * Use of survival modeling to asses the impact of clinical data and genetic variants on severity of rare disease. Technical skills:* Programming: experience in R (8 year), Java (7 years)* Machine learning: clustering, classification * Statistics: survival modeling, lasso, enrichment* Cloud computing: experience running analyses in EC2/S3, using AWS apiMisc:* Reproducible research: systematic use of self-documenting Rmarkdown to produce analysis reports that can be re-created later. * Leadership: extensive mentoring of students of all levels (high school through PhD level), plus management of projects composed of peer contributors and consultants. * Informatics: excellent knowledge of informatics, including evaluation of data storage needs for lab experiments and an understanding of how information systems are experienced by users of all levels. * Datasets: GTeX, CCLE, TCGA, ExAC, COSMIC
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Founder And CeoDiamond Age Data Science Aug 2016 - PresentBoston, Massachusetts, UsAs founder of Diamond Age, I have led the company from a small, project-based service provider to a full-fledged consultancy that works closely with clients to tackle their most difficult research challenges.Diamond Age is a team of bioinformaticians, biostatisticians and engineers who help fast-moving biotech companies make the best use of their data. We guide experimental design, implement systems and provide statistical guidance for complex biological datasets.
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Board Of Directors, Treasurer, Chair Of Governance CommitteeWest - Women In The Enterprise Of Science And Technology Jan 2020 - Jul 2024Cambridge, Ma, Us -
Computational Biologist And Data ScientistThe Broad Institute Of Mit And Harvard Dec 2012 - Jul 2016Cambridge, Ma, UsComputational biologist at-large, contributing to several therapeutics development projects as a scientific team member. • Lead the investigation into genetic influences on the progression of MKD kidney disease. Connected clinical and genomic data to build a time-to-failure model of age of onset of kidney failure, identifying genetic markers of disease severity. Coordinated with clinical collaborators to obtain and curate appropriate data for these models and other project needs.• Synthetic lethal drug discovery in cancer. Investigated functional assay data to identify synthetic lethals: genes that, when knocked out in combination with another gene of interest, lead to cell death. Worked closely with scientists to develop novel methods for identifying and validating synthetic-lethal pairs.• Target ID for cardiovascular disease compounds. Worked with biologists to identify the target pathway of a compound screening hit using RNA-Seq and microarray analysis.• Compound target validation for cancer target screening hits. Used transcriptional profiling of compounds and genetic knockdown screens to validate mechanism of action. -
Bioinformatician, Project LeadDana-Farber Cancer Institute Mar 2005 - Feb 2012Boston, Ma, UsLed the team that developed and maintained MultiExperiment Viewer (MeV), a software tool for mining large genomic datasets. MeV includes powerful statistical and machine learning tools that non-programming biologists can use to analyze biological data. Was responsible for the software being accurate, easy to use, and frequently updated.• Project management: led a soup-to-nuts software engineering and customer support project.• Leadership: led software engineers, students and computational biologists of varying backgrounds and levels of experience.• Methods development: developed a new module that identified transcriptional profiles predictive of altered survival times.• Software engineering: refactored the state-saving functionality to allow cross-platform and cross-version compatibility.The MeV team produced releases with substantial new features every six months for over six years. We enabled our thousands of users without programming skills to rigorously analyze large genomic datasets. We were then awarded a 5-year, $3M grant to continue our work. -
Bioinformatics AnalystThe Institute For Genomic Research Sep 2002 - Mar 2005Interfaced between scientists and computationalists working with DNA microarray technology. • Taught biologists to use the analytics tools in the TM4 Microarray Software Suite to cluster, visualize, statistically test and otherwise data-mine their genomic data. Assisted graduate students, postdocs and scientists in QC, normalization and data mining of microarray experiments.• Built data portal for scientists to search access all data for hundreds of genomics experiments.• Curated microarray data in databases. Ensured data was consistent and complete. Converted ad-hoc curation to script-driven automated processes.
Eleanor Howe Skills
Eleanor Howe Education Details
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University Of OxfordBioinformatics -
University Of Wisconsin-MadisonCellular And Molecular Biology
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University Of MichiganCellular And Molecular Biology
Frequently Asked Questions about Eleanor Howe
What company does Eleanor Howe work for?
Eleanor Howe works for Diamond Age Data Science
What is Eleanor Howe's role at the current company?
Eleanor Howe's current role is Founder and CEO of Diamond Age Data Science.
What is Eleanor Howe's email address?
Eleanor Howe's email address is el****@****ail.com
What is Eleanor Howe's direct phone number?
Eleanor Howe's direct phone number is (617) 714*****
What schools did Eleanor Howe attend?
Eleanor Howe attended University Of Oxford, University Of Wisconsin-Madison, University Of Michigan.
What are some of Eleanor Howe's interests?
Eleanor Howe has interest in Programming, Civil Rights And Social Action, Bioinformatics, Science And Technology, Micrornas, Statistics, Data Mining, Cancer Biology, Health.
What skills is Eleanor Howe known for?
Eleanor Howe has skills like Bioinformatics, Genomics, Computational Biology, Molecular Biology, Biotechnology, R, Programming, Statistics, Data Mining, Microarray, Biology, Gene Expression.
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