Eli Fine, Ph.D Email and Phone Number
Eli Fine, Ph.D personal email
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I am a seasoned Automation Leader with 13 years of experience in laboratory automation and informatics spanning molecular biology, NGS, human iPSC culture/differentiation/screening, analytical assays for biologic/gene therapies, and genome engineering. I enjoy building high performing automation and software teams that serve as the 'glue' between the science, the lab, and digital. I have developed and deployed small and large automation/software platforms across discovery, research, process & analytical development, driving the science, operational excellence, and improvement in throughput. I have lived on the cutting edge during my whole career, building both first-in-class and best-in-class automation/software platforms, with close partnership with industry vendors. Whether it’s a small robot, integrated platform, data pipeline, LIMS, or novel piece of scientific instrumentation, I firmly believe that the user experience has to be a first principle; whether it’s for an internal scientist or the company’s customers, my teams always frame everything we build as a Product.I am a strong believer that automation in the lab is much more than understanding how to use a robot to move samples and liquids. I build cross-functional teams that write front-end and back-end code running on-prem and in the cloud, while collaborating with data engineering, IT security, and AI/ML teams to deliver a truly transformational product for the scientist. Throughout my career I have integrated these principles into automation deliverables, and as a result have developed robust, scalable, intuitive, and transformational products that the scientist is actually able to use.I love problem solving, living in the gray, wearing many hats, and building from the ground up.▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬● Equipment: Hamilton STAR & NIMBUS, Lynx, Formulatrix Mantis, Integra ASSIST Plus, I.DOT, CellCelector, Beckman Coulter Biomek, LiCONiC STX, Askion control-rate preservation, KX-2 arm/rail, InHeco ODTC, a4S & X-Peel, VSpin, LabElite ID Capper● Cloud: AWS Lambda, AppStream, S3, SSM, EventBridge, SQS, RDS, ECR, EC2● SaaS: Benchling, Quilt● Front-end: VueJS, PyQt, Electron● Back-end: Python, SQL (PostgreSQL, MySQL, SQLite)● Testing: TDD, Unit, Integration, End-to-End, Pytest, Jest, Testcafe● DevOps: Pulumi Infrastructure as Code, GitHub/GitLab/CodeBuild CI Pipelines, Docker, Devcontainers● Data Science / Informatics: Illumina & PacBio read alignment (bowtie2, STAR, Needleman-Wunsch, Waterman), Edena genome assembler, BLAST, UCSC Genome Browser, scikit-learn, Perl
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Principal Lab Automation Software EngineerLab SyncSmyrna, Ga, Us
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Principal Lab Automation EngineerVivodyne Jan 2024 - PresentPhiladelphia, Pennsylvania, Us● Architecting and leading the technical implementation of a robust software stack enabling execution of scientific workflows on a cutting-edge custom-built 3D cell culture automation workcell● Partnering with scientists to gather requirements, prioritize feature development, and maintain a dynamic Agile backlog, ensuring alignment with R&D and client goals● Developing high-performance device drivers for complex instruments such as Zeiss LSM Confocal, Hamilton Zeus pipettes, KUKA robotic arm, PhoenixContact PLC, and Hiwin motion stage, enabling coordinated asynchronous operations. Utilizing tooling such as Python, C#, gRPC, CAN bus, and TCP sockets● Designing a virtualized state representation for all devices and objects in the workcell, facilitating high-fidelity in silico simulations and ensuring robust Continuous Integration testing● Built and deployed a cloud-first scalable architecture for fleet management of multiple workcells; containerized deployment managed by AWS Systems Manager for code executing on-prem, which communicates with a purpose-built high availability full stack web application -
Genome Engineering / Gene Therapy / Genomics ConsultantIndependent Consultant Feb 2014 - PresentProviding experimental design, computational analysis, operational efficiency improvements, patent filings, and grant writing services to academic institutions and life science companies ranging from angel/venture/SBIR funded start-ups to Fortune 500. See http://www.EliFine.com for more information.▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬● Designing CRISPR and TALEN nucleases for optimal on-target activity and low off-target activity● Designing donor plasmids to facilitate therapeutic gene repair● Viral integration site analysis● Creating drawings and supporting information for patent claims● Subject Matter Expert analyses for Venture Capital Due Diligence
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Director Of Automation & Process EngineeringResilience Apr 2021 - Dec 2023San Diego, Ca, Us● Leading an Agile team of robotic and software engineers to architect and implement robotic laboratory solutions across the company (five sites across CA, FL, MA)● Projects involving automated liquid handlers, robotic arms and peripherals, creating AWS cloud data analysis workflows, and interacting other cloud LIMS/ELNs● Biological focus areas include genome engineering (human and E. coli), cell line development, synthetic biology, analytical assays, cell-free protein synthesis, and downstream purification -
Director Of Laboratory Automation & Data ScienceCuri Bio Apr 2019 - Apr 2021Seattle, Washington, Us● Leading a full-stack Agile software team to develop desktop software controlling novel scientificinstrumentation, and customer cloud analysis portals to perform large scale analyses on collected data.● Designing laboratory automation solutions to accelerate internal R&D and sell to external customers● PI for NIH SBIR grant to investigate manufacturability of cryopreserved Assay Ready Plates of iPSC-CardioMyocytes (1R43HL154928-01)● Subaward PI conducting AI analysis on data collected by HESI consortium for next gen drug safety screening -
Sr. Director Of Data Science & Laboratory AutomationCoyne Scientific Jul 2015 - Jan 2019Served as the primary architect and manager of Coyne Scientific's highly automated stem cell laboratory and data analysis pipelines to study the effects of genetic variation on in vitro toxicity responses of human cells to pharmaceutical compounds. ▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬SR. DIRECTOR OF DATA SCIENCE & LABORATORY AUTOMATION (January 2017 - Present)● Communicated scientific results to clients, executives, and investors; presented at national conferences● Designed, integrated and programmed a $1 million automated system for human stem cell culture & assays● Populated and analyzed a large scale database of internal results containing tens of millions of data rows● Managed a small software team using Agile to build our research tools infrastructure & ensure code quality● Developed a model describing population variance of adverse effects in vitro applying significance testing ● Created a digital biological image data analysis pipeline to transform raw data into actionable results● Optimized performance of custom data analysis pipelines using multiprocessing and cloud computingDIRECTOR OF GENOMIC SCIENCE (July 2015 - December 2017)● Developed an assay from bench through analysis for RASL-seq whole transcriptome profiling of human cells● Constructed and administered a MySQL database to allow querying of in-house scientific & operational data● Interviewed and hired staff at levels from technician through PhD as the scientific team grew from 2 to 7● Automated data visualization using matplotlib and LaTeX to create reports for clients and for internal use
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Phd StudentGeorgia Institute Of Technology & Emory University Aug 2010 - Apr 2015Atlanta, Georgia , UsOptimized engineered nucleases for genetic correction of sickle-cell anemia▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬● Constructed TAL Effector Nucleases and CRISPR/Cas9 systems● Constructed donor repair templates● Optimized DNA repair pathway choice● Discerned factors affecting nuclease activity and creating models to predict optimal target sites● Analyzed nuclease off-target effects and creating bioinformatics models to predict off-target sites -
Genomics InternExpression Therapeutics Jun 2014 - Aug 2014● Developed a laboratory protocol for retroviral integration site analysis and standardized it as an SOP● Created a custom bioinformatics pipeline to process NGS deep sequencing data for integration site analysis
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Undergraduate Student ResearcherBrown University Fairbrother Lab Jun 2009 - May 2010Providence, Rhode Island, UsUsed bioinformatic and molecular biology techniques to find evidence for novel cases of stop codon readthrough in Drosophila and human genomes.
Eli Fine, Ph.D Skills
Eli Fine, Ph.D Education Details
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Georgia Institute Of TechnologyBiomedical Engineering -
Scheller College Of Business (Georgia Institute Of Technology)Management Of Technology Certificate
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Brown UniversityBiomedical Engineering
Frequently Asked Questions about Eli Fine, Ph.D
What company does Eli Fine, Ph.D work for?
Eli Fine, Ph.D works for Lab Sync
What is Eli Fine, Ph.D's role at the current company?
Eli Fine, Ph.D's current role is Principal Lab Automation Software Engineer.
What is Eli Fine, Ph.D's email address?
Eli Fine, Ph.D's email address is el****@****ail.com
What schools did Eli Fine, Ph.D attend?
Eli Fine, Ph.D attended Georgia Institute Of Technology, Scheller College Of Business (Georgia Institute Of Technology), Brown University.
What skills is Eli Fine, Ph.D known for?
Eli Fine, Ph.D has skills like Molecular Biology, Pcr, Cell Culture, Flow Cytometry, Bioinformatics, Matlab, Python, Western Blotting, Genetics, Automated Liquid Handler, Perl, C++.
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