Innovative multi-disciplined R&D manager and engineer with 13 years of experience developing and commercializing products that incorporate: cloud applications, chatbots, IoT technology, multi-degree-of-freedom robotic motion control, and body-worn human interfaces.

• Created an online dashboard for collecting and visualizing gas, electric, and water utility consumption data.• Made strategic decisions on software design patterns and full-stack software development tools to create scalable applications.• Analyzed utility consumption data and developed novel visualization methods for analysis that extended Google’s Material Design principles.

• Led the overall development of a second-generation powered upper-limb assistive orthotic device with an 80% cost reduction compared to the first-generation device.• Directed all software and electrical aspects of commercial devices (two generations) and grant-funded research projects, including fully robotic orthotic hand devices and an upper-limb orthotic device, each with 5-6 powered degrees of freedom.• Managed a patent portfolio of 8 patents, each with multiple national entries, and worked with legal counsel to respond to office actions and set strategic objectives.• Personally invented and contributed to several novel mechanisms for limb and joint actuation.• Managed and developed electronic systems, embedded firmware, mobile and web front-end interfaces, and cloud back-end systems.• Led development of a rapid prototyping strategy that resulted in 4 iterations of device designs and functional testing with 30+ users in just 6 months from project start.• Worked closely with business team to create R&D budgets, development timelines, and product requirements and communicate potential business opportunities and risks.

• Developed, deployed, and maintained a scalable online crowdfunding platform that allowed users to create a structured video campaign and raise funds for their projects using a chatbot interface.• Created chatbot AI technology that guided users through the process of creating short video clips that were dynamically merged into a coherent crowdfunding pitch video.• Developed beta testing strategies for exploring product/market fit and validating platform value propositions.

• Developed genome-scale computational models of plant and microbial metabolism using network modeling approaches and numerical optimization.• Designed algorithms that leveraged multiple independent data sources to improve on state-of-the-art methods and derive biological insights.• Published research in peer-reviewed journals and gave oral presentations at international conferences.Publication list:Krumholz, E. W., & Libourel, I. G. L. (2017). Thermodynamics constraints improve metabolic networks. Biophysical Journal. 113(3), 679-689.Krumholz, E. W., & Libourel, I. G. L. (2015). Sequence-based metabolic network gap-filling reveals the integrality of missing reactions in metabolic networks. Journal of Biological Chemistry, 290(31), 19197–19207.Yang, H., Krumholz, E. W., Brutinel, E. D., Palani, N. P., Sadowsky, M. J., Odlyzko, A. M., Gralnick, J. A., Libourel, I. G. L. (2014). Genome-scale metabolic network validation of Shewanella oneidensis using transposon insertion frequency analysis. PLoS Computational Biology, 10(9), e1003848.VanderSluis B., Hess D. C., Pesyna C., Krumholz E. W., Syed T., Szappanos B., Nislow C., Papp B., Troyanskaya O. G., Myers C. L., Caudy A. A. (2014). Broad metabolic sensitivity profiling of a prototrophic yeast deletion collection. Genome biology, 15, R64.Krumholz, E. W., Yang, H., Weisenhorn, P., Henry, C. S., & Libourel, I. G. L. (2012). Genome-wide metabolic network reconstruction of the picoalga Ostreococcus. Journal of Experimental Botany, 63(6), 2353–62.