Support discovery and development projects by following bioanalytical ADC procedures and validation protocols with GLP and GMP compliance, Develop bioanalytical methods based on LC/MS platform to support clinical and non-clinical projects. Trouble-shoot LC/MS instrument related issues and coordinate the PM of instrument.Train colleagues from other groups on assays, autosampler operation and Kingfisher instrument operation. Maintain accurate laboratory records and notebooks and write bioanalytical PK/TK reports and SOPS to support IND projects. Provide PK WinNonlin when needed, prepare PPT and communicate and collaborate cross-departmentally about BA/PK data findings

Performing assays on client compounds for CYP P450 Inhibtion TDI/Direct, Bioanalysis/Method Development, CYP Induction Quantification, UGT Inhibition, compound management and turbidimetric solubility. Manually tune compounds on AB Sciex 6500/5500 and Waters Xevo Comfortable with the following: AB Sciex 6500/5500, Waters Xevo, Shimadzu LC30AD, Analyst, Masslynx, Targetlynx, Openlynx, Multiquant

Successfully validated, cross-over, tested, and supported in the development of new commercial LC/MS/MS assaysActively perform protein precipitation, liquid-liquid and solid-phase extraction assays on plasma and urine matrices for small molecule biomarkers Gb3, Lyso Gb3, and Lyso Gb1 LC/MS/MS assays according to SOP in a GCLP/GLP, CAP and CLIA compliant laboratory environmentMaintain, setup, and troubleshoot LC/MS/MS instrumentation such as collision energy titration testing, cone cleaning, column replacement, and altering parameter settings to optimize peak intensity for analyte of interestMulti-task and manage routine laboratory work flow by preparing buffers and solvents, inventory Deliver patients' testing results within short turn-around times following CLIA guideline/procedure. Expedite data processing when neededTrain and oversee peers/new personnel on maintenance and troubleshooting instrumentation, and company policy and procedureDraft and edit SOP's for new and existing assays, and continuously improve assay extraction related worksheets

Conduct screening for metabolic and lysosomal storage disorders (LSD) in newborns domestically and internationallyPerform daily preventative maintenance on AbSciex 3000 and 3200 and Waters Quattro micro mass spectrometer instruments consisting of curtain plate and orifice cleaning, and tuningMaintain laboratory workflow from hole-punching, extracting, drying, and processing patient samples while adhering to company turn around timeWork well under pressure with time constraints in high-volume environments.Data analysis of quality control and abnormal patient results.Prepare LSD reagent cocktails, buffer solution, mobile phase and rinse solvent for testingAssist validating research methods and proceduresWork in conjunction with supervisory personnel and other medical technologists to train and orient new employeesFamiliar with LIS and Sciex Analyst software, Caliper Zephyr liquid handler, utilizing multichannel pipettors, LC/MSTroubleshooting skills such as: -changing capillary, inner electrode, silica line, and silica line tubing-cleaning/replacing parts of the injector valve of AbSciex 3000, 3200 and auto samplers

Reading adult, research and baby differentials including manual reticulocyte and platelet countsCall nurses or doctors with critical values and questionable samplesMake slides for pathologist consultations Notify lead technologists, supervisors and next shift about instrument issues or patient samplesRun arterial and venous gas samples, ECMO, osmolality, closure time, thromboelastograph (TEG), and aspirin and plavix response testsMaintain and run coulter and slide stainer instruments by performing quality control and assurance tubes, body fluid controls, replenish needed reagents, and cleaning one of the slide stainer's