Emilie Simon, Phdsc Email & Phone Number

Paris, Fr

Paris, Île-De-France, France

Age-Related Macular Degeneration & Phytochemicals

France

RetinaCARE, preclinical development of an innovative non-viral gene therapy for retinal degeneration:Retinal degenerative diseases such as dry age-related macular degeneration (AMD) are major causes of human blindness worldwide. Iron is essential for retinal metabolism and visual cycle, however, an excessive amount of labile iron (Fe2+) generates reactive oxygen species leading to the oxidation of the cellular components. In order to regulate the iron homeostasis and avoid a tissue overload, several proteins are involved in the iron transport, storage and regulation. Indeed, iron is transported across cell plasma membranes by transferrin (TF) by binding to TF receptor 1 (TFR1). Evidences suggest that iron toxicity could be a pathological mechanism involved in different type of retinal degeneration. The level of iron into the macular region is higher in early AMD patients compared to healthy patients. Iron deposits have been found into melanosomes (from choroid and RPE), drusens, and the Bruch’s membrane and photoreceptor layers. The level of iron in aqueous humor from dry AMD patients has been also found to be two-fold higher than in healthy patients. Whether iron dysmetabolism in the retina is a cause or a consequence of various retinal disease, iron accumulation is pathogenic, and its neutralization was shown to protect the retina from oxidative damage and retinal cell death in various models.The aim of the project was to develop and provide an innovative non-viral gene therapy medicinal product targeting iron chelation in order to reduce oxidative stress, slow down the degenerative process and so preserve vision.http://www.crc.jussieu.fr/francine_behar_cohen2019.html

Weybridge, England, United Kingdom

Research on Transmissible Spongiform Encephalopathies

Centre For Biological Sciences, Southampton

Pharmacological modulation of CSF1R activation to control microglial proliferation in neurodegenerative diseases: The expansion and activation of microglia, the brain’s resident population of myeloid cells, is a hallmark of many neurodegenerative diseases. Colony stimulating factor 1 receptor (CSF1R) is involved in regulating microglial proliferation, and CSF1R blocking strategies have been recently used to modulate microglia in neurodegenerative diseases. CSF1R has two ligands that bind with high affinity, CSF1 and IL34. The two ligands display a differential temporal and spatial pattern of expression, and subtle differences in the signalling cascade, suggestive of a complementary role for these molecules. The aim of the project was to generate tool compounds and validation data to provide confidence thatcontrol of the microglial response could be a potential therapeutic approach for AD.

Centre For Biological Sciences, Southampton, United Kingdom

Neuroinflammation in age related macular degeneration and long-chain omega-3 polyunsaturated fatty acids

Institut Pasteur De Lille

ALGOVUE StudyEvaluate the impact of the daily consumption of 2 eggs rich in lutein/zeaxanthin from lucerne protein concentrate and DHA from microalgae 1) on the plasma levels of these compounds,2) on the macular pigment optical density, whose the increase may be beneficial in the prevention of age-related macular degeneration.

Région De Dijon, France

Evaluate the systemic and retinal bioavailability of long-chain omega-3 polyunsaturated fatty acids from dietary phospholipids.

Inra

"Participation of nutritional and environmental factors to aging of the retina and age-related retinopathies"Aim :1) evaluate the effects of nutritional, environmental or endogenous factors generating oxidative stress and AGEs on the retina in a murine model of aging of the human retina: the ApoB100,LDLR-/- mouse.2) evaluate the response of the retina to a long-chain omega-3 polyunsaturated fatty acids-enriched diet (EPA and DHA).

University Of Paris Xii

Transdifférentiation of mesenchymal stem cells in corneal epithelial cells

Master 2 Speciality : Aging, Biology

Phd, Biology

Master 1 - Biology, Health

Licence - Cell Biology And Animal Physiology

Deug - Life Science