Emily Cook Email and Phone Number

Molecular Glue Team-Screening of small molecule libraries to identify novel molecular glues working through TPD established E3 Ligases and novel E3 ligases using protein microarrays-Discovery of novel neo-substrates-Characterization of degradation, ternary complex formation, and binary binding

Principal Investigator: Seth Margolis Project: A Proteomics Approach to Identifying Novel Substrates of an E3 Ubiquitin ligaseo Project manager for 3 years which included mentoring summer interns and rotation studentso Troubleshot an in vitro ubiquitination protocol to make it more efficiento Scaled up an in vitro ubiquitination method to apply it in a more high-throughput scenarioo Initiated and maintained two collaborations with other laboratoriesProject: Genetic Removal of a Neuronal Protein Rescues Deficits in a Mouse Model of a Neurodevelopmental Disordero Managed my time between multiple projects occurring simultaneouslyo Quickly learned new techniques to assist a team after a student graduatedo Work resulted in a co-first author publication currently in preparation

Intern in Biopharmaceutical Development department using LC-MS based approaches to identify host cell proteins (HCPs) in samples from different stages of the purification process of various drugs including enzyme and antibody based therapies.

As a Post-baccalaureate researcher at the NIH, I worked in the lab of Dr. Richard Proia in the NIDDK, studying sphingolipid diseases. I specifically worked on a team studying the neurodegenerative disorder, Sandhoff Disease. My role was to use CRISPR-Cas9 to genetically rescue an iPSC line derived from a Sandhoff patient. We then differentiated the Sandhoff patient and the genetic rescue iPSC lines into cerebral organoids to develop and in vitro model of Sandhoff Disease. This work was later published in The Journal of Lipid Research.

Principal Investigator: Jeffrey BrodskyProject: The role molecular chaperones in targeting proteins for Endoplasmic Reticulum Associated DegradationSkills Developedo Developed a schedule to manage my time between classes and experimentso Work was presented at a regional conference and resulted in a middle author publication