Eric Bennett work email
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Eric Bennett personal email
I lead the structure-based engineering & crystallography group for large molecule therapeutics at Pfizer. My background ranges from antibody and native protein optimization to mRNA and structure/ligand based small molecule design. I have worked with with targets in oncology, inflammation, infectious disease, neuroscience, and hemostasis including cytokines/cytokine receptors, kinases, proteases, and ion channels. A significant focus of our current work is collaboration with AI/ML experts on in silico prediction of protein physical properties and design of libraries targeting optimal regions of sequence space.Specialties: Antibody affinity/physical property optimization and in silico prediction, protein stabilization, protein/protein interface design. Structure & ligand based drug design. Homology modeling, MD, docking, pharmacophore modeling, QM.Extensive experience with Schrodinger products, Rosetta, Modeller, OEChem, Foldx, and Perl. Expertise with ViennaRNA, OEChem, PostgreSQL, NAMD, Pipeline Pilot/Discovery Studio, ROCS, Python, Linux systems administration in HPC cluster environments with LSF/Torque/Maui/SLURM, C.
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Senior DirectorPfizerCambridge, Ma, Us
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Research FellowPfizer Apr 2019 - PresentNew York, New York, UsI lead the computational design and crystallography team for biotherapeutics at Pfizer. Our scope includes antibodies, fusion proteins, gene therapy constructs, and mRNA. Using molecular structure modeling and informatics, the group optimizes properties including affinity, physical/chemical stability, and immunogenicity. We collaborate closely with experimental library display teams (designing libraries focused on optimal regions of sequence space) and the AI/machine learning group (developing tools to predict physical properties based on sequence or structure).
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Associate Research FellowPfizer Jun 2016 - Apr 2019New York, New York, UsI lead the structure-based in silico biotherapeutic design team at Pfizer. Using protein structure modeling and informatics, the group optimizes properties including affinity, physical/chemical stability, and immunogenicity. Our close relationship with experimental library display groups, designing libraries focused on optimal regions of sequence space, has been successful on multiple projects. The group also works on engineering next-generation antibody platforms, leads external partnerships, and investigates predictive models for physical/manufacturing properties.
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Senior Principal ScientistPfizer Jun 2013 - May 2016New York, New York, UsOptimization of protein therapeutics using molecular modeling and bioinformatics. Scientific lead for external collaboration with small biotech firm. Current areas of focus include antibody humanization, in silico affinity maturation, protein interface redesign, protein stability and selectivity enhancement, engineering sites for bioconjugation, optimization of phage display sequence space selection, and development of automated web-based antibody structure/sequence analysis tools.Linux cluster management including queue systems, database and web servers hosting scientific applications, and optimization of application performance on High Performance Computing clusters. Critical role in defining R&D department's requirements for design of next-generation HPC systems.Individual performance awards in 2012, 2013, and 2016 based on nominations from colleagues in other departments.
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Principal ScientistPfizer Jan 2010 - May 2013New York, New York, Us
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Senior Research Scientist IiPfizer Jan 2008 - Dec 2009New York, New York, UsSenior Research Scientist (computational chemistry) supporting oncology, inflammation, and neuroscience projects through structure/ligand based small molecule design and antibody humanization. Primary comp chem group contact for IT-related issues including performance tuning and workflow automation.
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Assistant Director & Assistant ProfessorCenter For Drug Design, University Of Minnesota Sep 2005 - Jan 2008Minneapolis And St. Paul, Minnesota, UsResponsible for comp chem / molecular modeling aspects of drug discovery projects in collaboration with 4 med chem labs. Co-investigator on 3 grants. Experience with structure-based design and virtual screening on antiviral (HIV), antibacterial (tuberculosis), and oncology projects. Supervised postdoctoral research. Departmental server administrator. -
Postdoctoral AssociateCenter For Drug Design, University Of Minnesota Mar 2004 - Sep 2005Minneapolis And St. Paul, Minnesota, UsComputational design & modeling of small molecule protease & PKS inhibitors.
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Graduate StudentCornell University 1997 - 2003Ithaca, Ny, UsX-ray crystallography and molecular modeling in polyamine and nucleic acid metabolism, including gene therapy protein engineering applications for oncology. Systems administrator for two computing labs, with 10 SGI and 10 DEC workstations.
Eric Bennett Skills
Eric Bennett Education Details
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Cornell UniversityMolecular And Cell Biology -
Penn State UniversityBiochemistry
Frequently Asked Questions about Eric Bennett
What company does Eric Bennett work for?
Eric Bennett works for Pfizer
What is Eric Bennett's role at the current company?
Eric Bennett's current role is Senior Director.
What is Eric Bennett's email address?
Eric Bennett's email address is er****@****box.com
What schools did Eric Bennett attend?
Eric Bennett attended Cornell University, Penn State University.
What skills is Eric Bennett known for?
Eric Bennett has skills like Drug Discovery, Drug Design, Bioinformatics, Molecular Modeling, Computational Chemistry, Biotechnology, Biochemistry, Antibodies, Chemistry, X Ray Crystallography, Protein Engineering, Docking.
Who are Eric Bennett's colleagues?
Eric Bennett's colleagues are Mark Petersen, Eric Coppeta, Layne Stanley, Krissia Berry Torres, Mona Esam, Shiekh Ravuthar, Alamar Cavada.
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