Eric T. Larson Email and Phone Number
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Structural biologist supporting hit finding, lead discovery, and lead optimization in a collaborative, multi-disciplinary team environment. Expertise in gene-to-structure pipeline for protein and protein-ligand complex structure solution and analysis using a high throughput X-ray crystallography platform. Proven track record of delivering key structures of challenging protein targets and insight to drive structure-based hit/lead finding and subsequent structure-based drug design campaigns. Strong background in molecular biology and protein biochemistry. Design and deliver functional, active, built-for-purpose protein constructs that enable biochemical and biophysical assay development to drive target validation and hit finding/lead discovery research. Specialties: Macromolecular X-ray crystallography, structure-based drug design, fragment-based drug design, protein biochemistry, direct X-ray fragment screening (cocktail crystallography), molecular biology, construct design
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Director Of Structural Biology And Protein ScienceDelphia Therapeutics Mar 2024 - PresentCambridge, Massachusetts, Us
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Director Of Structure Biology And Protein ScienceHotspot Therapeutics, Inc. Sep 2022 - Mar 2024Boston, Massachusetts, Us -
Associate Director, Structural BiologyRheos Medicines Feb 2021 - Jul 2022Lead protein production and structural biology group within Lead Discovery. Collaborate closely with biochemistry, biophysics, and medicinal chemistry team mates. Co-lead Target ID / Target Validation team to ensure well validated targets feed and maintain a diverse, immunometabolism-focused pipeline. Manage internal FTE and CRO FTE/FFS resources to deliver high quality results that drive drug discovery and target validation projects to timely, data-driven decisions.
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Principal Scientist, Structural BiologyRheos Medicines Jul 2019 - Feb 2021
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Principal Project ScientistHarkerbio Aug 2018 - Apr 2019Buffalo, New York, UsPlanned, executed, and managed gene-to-structure research projects for pharmaceutical and biotechnology clients to enable structure-based drug design methods for their small molecule and biologic drug discovery targets. -
Crystallography Core Lab Head / Structural Biology Project LeadHarkerbio Feb 2018 - Apr 2019Buffalo, New York, UsManaged resources, timelines, and technology implementation in the Structural Biology Core to deliver high quality crystal structures of novel proteins and protein:protein and protein:small molecule complexes to feed into client's drug discovery efforts.
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Senior ScientistHarkerbio Apr 2017 - Feb 2018Buffalo, New York, Us
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Senior Scientist, Structural ResearchBoehringer Ingelheim Pharmaceuticals Aug 2011 - Feb 2017Ingelheim Am Rhein, Rhineland-Palatinate, DeStructural biologist using X-ray crystallography and creative construct design to enable, support and guide drug discovery/development efforts in the Small Molecule Discovery Research Department. Integral member of project teams working closely with medicinal and computational chemists and biophysicists so that structural insight may be leveraged early and throughout the drug discovery process. -
Postdoctoral ResearcherUniversity Of Washington Nov 2006 - Aug 2011Seattle, Wa, UsStructural biologist in the Dept. of Biochemistry and the Medical Structural Genomics of Pathogenic Protozoa Consortium (www.msgpp.org). Advisor: Professor Ethan Merritt; tight collaboration with Professors Wim Hol and Wes Van Voorhis Solved x-ray crystal structures of proteins of potential therapeutic interest in the battle against tropical and other neglected eukaryotic pathogens. Structurally characterized proteins in complex with known ligands and with novel fragments identified via various FBS methods including fragment cocktail crystallography. These small molecule co-structures fed into a structure-based drug discovery/design pipeline.Major efforts were directed towards select amino acyl-tRNA synthetases and kinases from several eukaryotic parasites. -
ScientistParsons Engineering Science Jun 1994 - Jul 1998Chantilly, Virginia, UsWorked with scientists and engineers across multiple disciplines characterizing contamination extent, and contaminant-specific risks to site, surrounding environment, humans and other organisms at military and industrial sites. Collected and analyzed data and helped prepare reports for clients detailing the risks and possible courses of remediation. Also involved in carrying out monitoring and remedial actions at contaminated sites.
Eric T. Larson Skills
Eric T. Larson Education Details
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Montana State University-BozemanX-Ray Crystallography -
University Of Colorado BoulderAnd Developmental Biology
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Columbine High School
Frequently Asked Questions about Eric T. Larson
What company does Eric T. Larson work for?
Eric T. Larson works for Delphia Therapeutics
What is Eric T. Larson's role at the current company?
Eric T. Larson's current role is Director of Structural Biology and Protein Science.
What is Eric T. Larson's email address?
Eric T. Larson's email address is el****@****srx.com
What is Eric T. Larson's direct phone number?
Eric T. Larson's direct phone number is +49 613*****
What schools did Eric T. Larson attend?
Eric T. Larson attended Montana State University-Bozeman, University Of Colorado Boulder, Columbine High School.
What skills is Eric T. Larson known for?
Eric T. Larson has skills like Biochemistry, X Ray Crystallography, Molecular Biology, Structural Biology, Drug Discovery, Protein Purification, High Throughput Screening, Medicinal Chemistry, Protein Expression, Chromatography, Recombinant Dna Technology, Biophysics.
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