Evan Cimino Email & Phone Number

Wilmington, Delaware, United States

• Lead the daily operation of a small team of high performing scientists in support of drug discovery and development programs. • Responsible for weekly ADME screening, mechanistic assays to address compound/program specific needs and preclinical compound characterization to support IND filings.• Work with a wide variety of in vitro assays and further develop current technologies to enhance in vitro assays, including protein binding, clearance, Caco2 permeability, PAMPA… Show more • Lead the daily operation of a small team of high performing scientists in support of drug discovery and development programs. • Responsible for weekly ADME screening, mechanistic assays to address compound/program specific needs and preclinical compound characterization to support IND filings.• Work with a wide variety of in vitro assays and further develop current technologies to enhance in vitro assays, including protein binding, clearance, Caco2 permeability, PAMPA, etc.• Designed and implemented detailed protocols to train new team members on laboratory procedures and assays, improving onboarding efficiency and reducing training time while ensuring consistency and accuracy.• Work closely with DMPK Principal Investigators and Directors on issue driven mechanistic ADME studies.• Evaluate and interpret in vitro ADME data in context of IVIVC/IVIVE• Collaborated with group leadership to coordinate resource planning, manage capital budgets, and support strategic decision-making, ensuring efficient allocation of resources and alignment with organizational goals.• Extensive hands-on experience with LC-MS/MS and automation platforms used for in vitro ADME assays to support direct reports in their work and enable them to troubleshoot various technical issues. Show less

Wilmington, Delaware, United States

• Responsible for DMPK support of discovery and development projects including bioanalysis of PK and TK study samples• Perform LC-MS/MS quantitation of samples in a regulated, GLP setting. Including:o Sample Analysiso Validationo Method development• Independently analyze data, record data, prepare summary documents, and report data (written and oral) as needed• Conducted regulated bioanalysis for multiple clinical trials across Phase 1 to Phase 3, ensuring compliance… Show more • Responsible for DMPK support of discovery and development projects including bioanalysis of PK and TK study samples• Perform LC-MS/MS quantitation of samples in a regulated, GLP setting. Including:o Sample Analysiso Validationo Method development• Independently analyze data, record data, prepare summary documents, and report data (written and oral) as needed• Conducted regulated bioanalysis for multiple clinical trials across Phase 1 to Phase 3, ensuring compliance with regulatory standards while managing concurrent programs to support drug development efforts• Review study data as required• Collaborate with internal and external departments to maintain timely analysis and delivery• Author and contribute to reports for regulatory fillings as needed• Lead cross-validation initiatives with internal and external clients as needed• Active participant for FDA BIMO on-site inspection in 2022• Provide training to other scientists as required• Act as a backup for Sample Management with sample receipt, sample tracking, and Watson entry Show less

Wilmington, Delaware, United States

• Collaborated with clients to generate leads, identify growth opportunities, and enhance business development initiatives across laboratory and clinical research markets.• Consulted and assisted in the development of sales and business development strategies, targeting pharma and CROs on behalf of clinical research sites to grow the sites’ pipeline with applicable trials.• Supported multi-vendor laboratory instrumentation services, including maintenance, repair, installation, and… Show more • Collaborated with clients to generate leads, identify growth opportunities, and enhance business development initiatives across laboratory and clinical research markets.• Consulted and assisted in the development of sales and business development strategies, targeting pharma and CROs on behalf of clinical research sites to grow the sites’ pipeline with applicable trials.• Supported multi-vendor laboratory instrumentation services, including maintenance, repair, installation, and qualification for LC/MS, HPLC, ICPMS, and other advanced analytical platforms.• Contributed to the development and customization of IQ, OQ, and PQ protocols to ensure compliance with laboratory standards and optimize instrument performance.• Assisted in establishing preventative maintenance schedules to enhance instrument reliability and minimize downtime for diverse laboratory equipment. Show less

Newark, De

• FDA, GLP/GCP-compliant contract research organization supporting discovery, preclinical and clinical drug development. • Perform analysis of biological samples (plasma, urine, whole blood, serum, tumor and tissue) for the quantitation of proprietary and generic compounds and GLP methods. • Proficiency in extracting compounds from test matrix using liquid-liquid separation, solid phase extraction and protein precipitation extraction techniques, including automation. • Perform run… Show more • FDA, GLP/GCP-compliant contract research organization supporting discovery, preclinical and clinical drug development. • Perform analysis of biological samples (plasma, urine, whole blood, serum, tumor and tissue) for the quantitation of proprietary and generic compounds and GLP methods. • Proficiency in extracting compounds from test matrix using liquid-liquid separation, solid phase extraction and protein precipitation extraction techniques, including automation. • Perform run set up on LC-MS/MS equipment using Analyst software.• Operation of Tomtec Quatra 4 96-well automated sample extraction system. • Independently coordinate assigned workflow and satisfy study requirements in a timely manner.• Communicate with PI/senior staff regarding study events and results. Show less

Newark, De

• Act as a liaison with clients and CROs regarding incoming and received biological samples, drug substances, and compounds.• Use Watson LIMS for complex sample entry, study design, sample and analytical data tracking, and reconciliation.• Act as technical resource, trainer, and troubleshooter for Sample Coordinators.• Communicate directly with Supervisor and Management for operational and/or technical improvements.• Responsible for handling and recording all samples sent to QPS… Show more • Act as a liaison with clients and CROs regarding incoming and received biological samples, drug substances, and compounds.• Use Watson LIMS for complex sample entry, study design, sample and analytical data tracking, and reconciliation.• Act as technical resource, trainer, and troubleshooter for Sample Coordinators.• Communicate directly with Supervisor and Management for operational and/or technical improvements.• Responsible for handling and recording all samples sent to QPS to insure compliance with FDA regulations, GLP’s, and QPS SOP’s and maintaining proper paperwork and approval. Show less

Newark, De

Bachelor’S Degree, Biological Sciences

Activities and Societies: Anthropology Minor

Pre - Physician Assistant Coursework

Activities and Societies: Phi Theta Kappa Honors Society