Visiting researcher in Prof. Ellen Roche's Lab at IMES - MIT as part of a MISTI granted project.

Development of a Biomedical Product for a Cardiovascular Application Using a Bioprinting Process1. Definition of the future product: o Definition of the technical specifications with our collaborators (Surgeons from IHU – Liryc) o Establishment of general project planning: - Definition of the deadlines - Validation of the go/no go - Establishment of the general budget and human resources o Light market research for the product o Brainstorming to define and validate the process of engineering for the product2. Development and characterization of the future product: o 3D Designing and prototyping of the product o Validation of the engineering process of the product regarding EMA regulation o In vitro characterization of the product: - Mechanical studies - Histologic and biochemical studies o Reporting the advancements of the development and the characterization of the product o Animation of meetings with our collaborators o Writing the patent of the productTechnical Tools: o Pack Office (Word, PowerPoint, Excel) o ImageJ for image treatment o Tinkercad Autodesck® for CAD o Solidworks for CAD o Regulation (EC) n°1394/2007 on advanced therapy medicinal products o NGB and NGB-R Bioprinter designed by Poietis o Pro2 3D printer (plastic extruder) designed by Raise 3DSuccess: o Respected deadlines o Validation of the engineering process o Validation of the prototype o Patent under deposition

Development of an Autologous Bone Substitute Using Human Adipose-derived Stem Cells for Small Maxillofacial Repairs and Dental Surgery Applications 1. Definition of the bone substitute: o Definition of the technical specifications with our collaborator (Maxillofacial surgeon from the “CHU de Québec”) o Writing and obtention of ethic authorization for research that uses human cells o Establishment of general project planning: - Definition of the deadlines - Establishment of the general budget and human resources o Brainstorming to define and validate the process of engineering for the product2. Development and in vitro characterization of the bone substitute: o Validation of the engineering process for the bone substitute o In vitro characterization of the substitute: - Mechanical studies - Histologic, molecular, and biochemical studies o Reporting the advancements of the development and the characterization of the substitute o Animation of lab meetings with our collaborator3. Bone substitute grafting in an animal model and evaluation of its capacity to regenerate alveolar bone tissue for dental surgery: o Writing and obtention of a grant to finance the in vivo study o Writing and approval of an animal use protocol o Grafting of the substitute within Nude rats o In vivo characterization of the substitute o Reporting the advancements of the bone healing evaluation o Animation of lab meetings with our collaborator o Teaching to Bachelor degree "The Bioprinting for Regenerative Medicine Applications" Technical Tools: o Pack Office (Word, PowerPoint, Excel) o ImageJ for image treatment o MicroView for microCT image treatment o Graphpad Prism for statistical analyzes o Mendeley for referencesSuccess: o Respected deadlines o Nine oral presentations and 15 scientific poster presentations of the results o Publication of one scientific review and three scientific articles o Ph.D. graduation

Prevascularization of Human Self-assembled Bone-like Tissue Using Laser-assistedBioprinting

Scientometry of the Regenerative Medicine

Production of Large-sized Skin Substitutes for Future Clinical Applications

Soutien scolaire pour un élève de 5éme, 4éme et 3éme.