Fabio Alessandro Facchini Email & Phone Number

Gerenzano, Lombardia, Italia

Part of the Immunodiagnostic Research Unit of DiaSorin

Milano, Lombardia, Italia

Pro jects:1. Roles of Transcription Factor EB (TFEB) in Dendritic Cells (DCs) and macrophages.This is the main research project I worked on; it concerned the evaluation of possible roles of transcription factor TFEB in the modulation of the innate immune response.2. Human DC subtypes in the tumor microenvironment and during Sars-CoV-2 infection.I took part to this project aimed to investigate the role of specific DC subpopulations in different clinical settings, including colorectal and lung cancer, and during COVID-19 pathogenesis. My task was to collect tumor an blood samples from patients and to isolate immune cells from these specimens in order to perform single cell RNAseq technology. In this framework, I collaborated with di↵erent research groups at the National Institute of Molecular Genetics (INGM), including the one headed by Prof Sergio Abrignani.This experience led to two publications (see link attached)I also attached the reference by Prof. Francesca Granucci

Milano, Lombardia, Italia

In 2020 and 2021 I held the role of teaching assistant during the immunology laboratory for undergraduate students of the Biotechnology faculty.

Milano, Lombardia, Italia

Università degli Studi di Milano-Bicocca - Tutor: Prof. Francesco PeriProject: Therapeutic modulation of human innate immunity through small synthetic molecules.During the first two years of my my postdoctoral time I continued the research in the field of Medicinal Chemistry focusing my work on the development and characterization of a new class of molecules with adjuvant properties. For that purpose, I collaborated closely with Prof. Grisha Pirianov at Anglia Ruskin University in Cambridge (UK), with Prof. Francesca Granucci at the University of Milano-Bicocca and with Prof. Ivan Zanoni at the Harvard Medical School (USA). This experience strongly improved my cellular biology expertise in the field of immunology. During this period, (in 2018) my research advisors, Prof. Francesco Peri, put me in charge of the organization of Microbiotami2018 international event, making me part of the organizing committee. This period led to three publications (see attached links)I also attached the reference by Prof. Francesco Peri

Milano, Italia

Project: Design, screening and characterization of new modulators of hTLR4, in order to reduce inflammation in different clinical settings.During the PhD I contributed to the TOLLerant project, a Marie Sklodowska-Curie Innovative Training Network (MSCA-ITN) funded by Horizon 2020 EU program and coordinated by Prof. Francesco Peri. The multidisciplinary research project was focused on the study of molecular mechanisms of innate immunity, in particular Toll-like Receptors (TLR) activation and signaling and their therapeutic targeting. During this period, I also have the possibility to work closely with Dr. Ivan Monteleone in the laboratory of immunology headed by Giovanni Monteleone at the Università di Roma ”Tor-Vergata”, with the aim to perform in vivo experiments and test on colon specimens from IBD patients. This experience greatly hone my social and organizational skills, my cellular biology expertise and enabled me to approach the field of immunology. I completed the doctorate with four publications (see attached link)).

Cambridge, Inghilterra, Regno Unito

Scientific supervisor: Prof. Grisha Pirianov; Purpose: training and education.I spent in total 5 months at the Laboratory headed by Prof. Grisha Pirianov at Anglia Ruskin University in order to collaborate on the characterization of a new class of molecules with adjuvant properties. This experience greatly improve my organizational and social skills and allowed me to publish the attached publication.

Roma, Lazio, Italia

Scientific supervisors: Prof. Giovanni Monteleone and Dr. Ivan MonteleonePurpose: I spent in total 8 months at the Laboratory of Prof. Giovanni Monteleone in order to obtain knowledge, perform in vivo studies and conduct experiments on specimens from inflammatory bowel disease (IBD) patients. This experience led to the attached publication.

Milano, Italia

Selezionato tramite concorso, partecipa allo stage “LO STUDENTE RICERCATORE”: progetto di integrazione tra ricerca e scuola. Ho svolto attività di ricerca con relazione finale dal titolo: “Valutazione di alcuni parametri del ciclo vitale di Caenorhabditis elegans impiegato come modello per lo studio della funzione di proteine.”L'esperienza vissuta durante lo stage è stata esposta in occasione di due eventi: mostra "Dalle cellule alla Bioinformatica" (Festival della scienza - Genova) e convegno " Al domani pensiamoci...oggi" presso Fondazione Cariplo di Milano.

Doctor Of Philosophy - Phd, Biotechnology, Excellent Cum Laude

Activities and Societies: Research project included in the TOLLerant project: "Design, screening and characterization of new modulators.

Master Degree, Biochimica E Biologia Molecolare, 110 E Lode

Activities and Societies: Lavoro di ricerca svolto durante il periodo di stage ha portato a due comunicazioni presso i seguenti congressi.

Laurea Triennale, Biologia/Scienze Biologiche, Generale, 102/110

Activities and Societies: Attività di ricerca presso IFOM ( fondazione istituto FIRC di oncologia molecolare); gruppo di ricerca del Prof..

Diploma Di Maturità Scientifico-Tecnologica, Liceo Scientifico-Tecnologico, 84/100