The main focus of my work is the ligase RtcB which is involved in XBP1 mRNA splicing downstream of the UPR sensor IRE1. The main finding of the project proposes a tyrosine phosphorylation (PY)-based regulation of RtcB activity and the subsequent control of cell fate. Lastly, the discoveries made in this project could help better understanding how ER stress signaling contributes to the development of diseases such as cancer (e.g. Glioblastoma Multiforme).

The main focus of the PhD project was to advance our understanding of autoregulation signaling at the Endoplasmic Reticulum (ER).The main achivement was the identification of the leukocyte tyrosine kinase (LTK) as the first ER-resident receptor tyrosine kinase that regulates COPII-dependent trafficking. This important finding makes LTK a druggable regulator of ER export in hyper-secretory conditions as cancer. Indeed, this work suggests that targeting the biosynthetic arm of proteostasis… Show more The main focus of the PhD project was to advance our understanding of autoregulation signaling at the Endoplasmic Reticulum (ER).The main achivement was the identification of the leukocyte tyrosine kinase (LTK) as the first ER-resident receptor tyrosine kinase that regulates COPII-dependent trafficking. This important finding makes LTK a druggable regulator of ER export in hyper-secretory conditions as cancer. Indeed, this work suggests that targeting the biosynthetic arm of proteostasis through LTK might be a new promising strategy in Multiple Myeloma treatment. Show less

My research interest was to understand various factors involved in wound healing processes. My focus would have been to understand the role of a protein, KLK10, potentially involved in wound healing, in particular in scar formation.