Francis Enane Ph.D. Email & Phone Number

Indianapolis, Indiana, United States

Technical subject matter expert (SME) for design and implementation of in-vitro cellular pharmacology-based assays. Support programs working with academic and industrial partners to develop therapies and molecular diagnostics (small molecules, monoclonal antibodies, and recombinant proteins), primarily focused on cancer, diabetes, neurodegenerative, cardiometabolic, and autoimmune disorders.• Develop modernized automation lab infrastructure to meet multi-investigator research needs.• Build automation team and train technical staff and associates to incorporate automated assays within R&D.• Lead development and automation incorporation into assay and project workflows for in vitro pharmacology experiments requiring cellular, molecular, and immunological techniques, including BSL2 tissue culture, cell-based assays, ELISAs, flow cytometry and high content imaging, and involving discovery of small and large therapeutic molecules and elucidation of mode of action.• Utilize large variety of detection technologies with development team to support programs / projects need through design and implementation of in-vitro cellular pharmacology-based assays and execution of molecular engineering strategies of lead molecules based on target characteristics, accessing broad range of biochemical and cellular assays, from assay development to automation.• Advance studying complex disease processes by proposing new ways to improve patients’ lives in evolving nature of life sciences research and encourage synergies through collaboration while enhancing integrated capabilities, adding depth to approaching patient-informed translational science, and pursuing foundational areas of scientific focus in a patient-centric framework. • Apply advanced analytics to data processing and visualization of high-throughput data.• Develop automated workflow and data processing algorithms for management of high-throughput process, data management and machine learning implementation.

Indianapolis, Indiana, United States

Expert in process automation, compound screening and high-throughput data handling across multiple research groups. Design and convert manual laboratory workflows into high-throughput automated workflows with assay miniaturization using cell-based in-vitro compound screening assays and liquid handling robots. Perform translation research across various therapy areas to identify unique biomarkers for novel therapy development. Project management of drug discovery research in hemoglobinopathies specifically sickle cell anaemia to define novel therapy using small molecule compounds. Collaborative research activities across other areas including obesity and diabetes. Active cross-functional researcher working across global teams. Active collaboration with medical affairs for clinical applications and translational research. Areas of special expertise and interest include:• Clinical trials • Drug discovery and compound characterization • Lead expert in automation, optimization & data handling• Expert in real world evidence and data analysis• Data cleanup, analysis and visualization

Indianapolis, Indiana, United States

Project management and marketing of life science automation technology in drug discovery automation market component across multiple industires including big pharma, academia, CROs and start-up. Performed projects to accelerate automation portfolio core growth in drug discovery market. Provided scientific leadership and expertise across multiple teams including automation software and hardware engineers, marketing managers, and project staff to build company understanding and access to target market segments. Performed customer facing projects to deliver marketing content and negotiate business relationships across biopharmaceutical industries, academia and biotech. Highlighted publications:1. https://www.moleculardevices.com/sites/default/files/en/assets/app-note/dd/img/automation-of-an-organ-on-a-chip-assay.pdf2. https://pubmed.ncbi.nlm.nih.gov/35093290/3. www.beckman.com/resources/reading-material/application-notes/automation-of-protein-a-elisa-assays-using-biomek-i7-hybrid-workstation

Indiana University Health

Translational research in oncology drug discovery for treatment of pancreatic cancer, Biomedical Entrepreneurship and commercialization of biomedical innovation

Indianapolis Indiana

Translational research in pancreatic cancer to identify biomarkers for novel therapy development. performed data-mining across multiple patient samples to perform meta-analysis and define underlying disease mechanisms. Perform in-vitro and in-vivo research to characterize unique biomarkers for therapeutic application. Publications: 1. https://pubmed.ncbi.nlm.nih.gov/30190481/

Cleveland/Akron, Ohio Area

Investigator in Molecular Medicine. Involved on various studies to understand the molecular mechanism of disease development and novel approaches to cure. Specifically work on translational cancer research to study the molecular mechanism by which cancer cells use to avoid cell cycle exit by terminal differentiation. Areas of interest involve:- Clinical Trials Research- Experimental cancer therapeutics- Cancer genomics and Epigenetics - Gene editing- Transgenic animal studies- Molecular and cellular biology- Multi-omic researchPublications: 1. https://pubmed.ncbi.nlm.nih.gov/28758902/2. https://pubmed.ncbi.nlm.nih.gov/34551289/3. https://pubmed.ncbi.nlm.nih.gov/30015632/

Hammond Indiana

Studied characterization glycosaminoglycans mainly heparin and hyaluronan and their role in pathogenesis. My studies defined how to use PeakFit software to characterize the sulfation pattern of heparin.

Undergraduate teaching assistant in chemistry and biological sciences

Purdue University Calumet

Supplemental instructor in Chemistry, Physics and Biology.

Undergraduate studies - Biotechnology.