Feng Jiang Email & Phone Number

Palo Alto, CA, US

Stanford, California, United States

Analyze GWAS data for autoimmune diseases.Developing a 'dsRNA model' to stratify autoimmune disease patients for personalized medicine

Rochester, NY

• Project: Understanding the function of an upstream open reading frame (uORF) on Gata4 mRNA in mouse cardiomyocyte hypertrophy
• Design and construct a genetic-modified mouse module lacking Gata4 uORF.
• Perform integrated data analysis of single-nucleus RNA & ATAC-seq in the mouse model to visualize transcriptional reprogramming in cardiac cells during hypertrophy.
• Identify and validate novel enhancers on hypertrophy-related gene transcription.

Rochester, NY

• Project: Antisense oligonucleotide (ASO) based RNA drug development and cardiomyocyte-specific delivery. (Collaborate with Empire Discovery Institute and Novo Nordisk A/S)
• Design and test ASOs to modulate gene expression and mRNA splicing to attenuate cardiac disease.
• Develop a pipeline and conduct data analysis for screening RNA aptamers entering cardiomyocytes efficiently.
• Test aptamer-ASOs fusions for gene expression modulation in cardiomyocytes.

Rochester, NY

• Project: Understanding the function of an RNA-binding protein, PRRC2B, in translational regulation
• Establish bioinformatic analysis platforms for NGS using the university local cluster.
• Plan and perform experiments studying RNA-protein interactions and mRNA translation such as CLIP-seq and polysome profiling.
• Perform data analysis for CLIP-seq to identify binding motifs of RNA-binding proteins.

Guangzhou, Guangdong, China

• Execute the NGS library construction and data analysis.
• Analyze Bulk/single-cell RNA-seq data obtained from human and mouse samples
• Use bash, R, and python to establish CHIP-seq analysis pipelines.

Rochester, NY

• Project: Understanding the function of an RNA-binding protein, PRRC2B, in translational regulation
• Design, construct, and maintain genetic-modified cell lines and mouse models.
• Plan and execute molecular biology experiments for protein function characterization such as Co-immunoprecipition and mass spectrometry.
• Plan and execute experiments for cell and mouse phenotyping including flow cytometry, histology, and echocardiography.

Rochester, NY

• Teach and supervise undergraduate students in biochemistry laboratories.
• Organize problem-based learning discussions.

Wuhan, Hubei, China

• Project: Construction of GLIS2 knockout HCT116 cell line with CRISPR/Cas9 technology
• Design CRISPR/Cas9 system to knockout GLIS2 gene in HCT116 cell line.
• Construct, select and maintain the GLIS2 KO cell lines.

Wuhan, Hubei, China

• Lead group discussions in the undergraduate molecular biology course.
• Prepare and grade exams.

Doctor Of Philosophy - Phd, Biochemistry And Molecular Biology

Bachelor'S Degree, Biology, General