Florian Barthélémy Email & Phone Number
@ucla.edu
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Who is Florian Barthélémy? Overview
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Florian Barthélémy is listed as Project Scientist at UCLA Department of Microbiology, Immunology and Molecular Genetics, a with 67 employees, based in Los Angeles, California, United States. AeroLeads shows a work email signal at ucla.edu and a matched LinkedIn profile for Florian Barthélémy.
Florian Barthélémy previously worked as Associate Project Scientist at Ucla Department Of Microbiology, Immunology And Molecular Genetics and Assistant Project Scientist at Ucla Department Of Microbiology, Immunology And Molecular Genetics. Florian Barthélémy holds Genetics from Aix-Marseille University.
Email format at UCLA Department of Microbiology, Immunology and Molecular Genetics
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About Florian Barthélémy
For over a dozen years, I have been engaged in the development of translational therapies to treat muscular dystrophies. As an associate project scientist, my focus lies in establishing and implementing patient-derived cellular models to screen potential therapeutic candidates for Duchenne Muscular Dystrophy (DMD). I am responsible for managing the biobank at our center, where I have collected, organized, and characterized hundreds of samples, including cells and biopsies, obtained from healthy as well as DMD patients over the past nine years. Additionally, I have derived and, at times, reprogrammed primary cells, such as fibroblasts, myoblasts, and satellite cells. These models are currently being used for drug screening and bioengineering designs by academic and several private partners. I have also played a significant role in developing most of the protocols employed in our laboratory, including biopsy freezing and handling, cell and tissue staining, cell outgrowth and reprogramming, myoblast fusion assays, and gene and RNA expression profiling.
Listed skills include Molecular Biology, Cell Culture, Cell Biology, Genetics, and 46 others.
Florian Barthélémy's current company
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Florian Barthélémy work experience
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Associate Project Scientist
Assistant Project Scientist
Post-Doctoral Scholar
Evaluation of small compounds to enhance exon-skipping in Duchenne Muscular Dystrophy
Phd Student
My thesis project was focused on dysferlin, a protein mainly expressed in muscle. There is some evidence that dysferlin is involved in several processes like T-tubule homeostasis, myoblast-myotubes fusion and membrane repair, even if these roles are not clearly demonstrated yet. Mutations in DYSF have been associated with Limb Girdle Muscular Dystrophies (type 2B) and Miyoshi Myopathy. The wide spectrum of mutations in DYSF, the absence of mutational hotspot and the size of the coding sequence force us to consider different therapeutic strategies. The major part of DYSF encodes evolutionarily conserved C2 domains which are well characterized Ca2+ sensor domains that mainly play a role in vesicle fusion process. Nevertheless, very few evidences have been showed regarding the specific functions of each of the 7 dysferlin C2 domains. Based on two natural proofs of concept, we have designed an exon-skipping strategy and a mini-gene based approach. These strategies while having a therapeutic purpose allow us to evaluate the modularity of dysferlin. To further understand how the biochemical properties of each domain may influence the functionality of the full length protein, and thus how some of them are essential, I performed biological and biochemical analysis and identified dysferlin functions that are specific for some of the motifs.
Florian Barthélémy education
Genetics
Doctor Of Philosophy (Phd), Human Pathology Speciality Human Genetics
Master'S Degree, Science, Technology, Health
Bachelor'S Degree, Biochemistry
Bts, Biotechnology
Frequently asked questions about Florian Barthélémy
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What company does Florian Barthélémy work for?
Florian Barthélémy works for UCLA Department of Microbiology, Immunology and Molecular Genetics.
What is Florian Barthélémy's role at UCLA Department of Microbiology, Immunology and Molecular Genetics?
Florian Barthélémy is listed as Project Scientist at UCLA Department of Microbiology, Immunology and Molecular Genetics.
What is Florian Barthélémy's email address?
AeroLeads has found 1 work email signal at @ucla.edu for Florian Barthélémy at UCLA Department of Microbiology, Immunology and Molecular Genetics.
Where is Florian Barthélémy based?
Florian Barthélémy is based in Los Angeles, California, United States while working with UCLA Department of Microbiology, Immunology and Molecular Genetics.
What companies has Florian Barthélémy worked for?
Florian Barthélémy has worked for Ucla Department Of Microbiology, Immunology And Molecular Genetics, Ucla Molecular Biology Institute / Center For Duchenne Muscular Dystrophy (Cdmd) At Ucla, and Umr_S910 (Inserm /Université De La Méditerannée).
How can I contact Florian Barthélémy?
You can use AeroLeads to view verified contact signals for Florian Barthélémy at UCLA Department of Microbiology, Immunology and Molecular Genetics, including work email, phone, and LinkedIn data when available.
What schools did Florian Barthélémy attend?
Florian Barthélémy holds Genetics from Aix-Marseille University.
What skills is Florian Barthélémy known for?
Florian Barthélémy is listed with skills including Molecular Biology, Cell Culture, Cell Biology, Genetics, Western Blotting, Fluorescence Microscopy, Life Sciences, and Bioinformatics.
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