Francesca Izzi Email & Phone Number

Tübingen, Baden-Württemberg, Germany

Translational Biomarkers in Neurodegenerative Diseases - Priv.-Doz. Dr. Christian Johannes GloecknerIn my second postdoctoral position, I completed the study of the LRRK2 interactome using proximity labelling techniques initiated during my previous role. Initial analysis of the mass spectrometry data enabled the identification of potential targets, which we intend to investigate further.Simultaneously, I am engaged in characterizing constrained peptides that target either LRRK2 or… Show more Translational Biomarkers in Neurodegenerative Diseases - Priv.-Doz. Dr. Christian Johannes GloecknerIn my second postdoctoral position, I completed the study of the LRRK2 interactome using proximity labelling techniques initiated during my previous role. Initial analysis of the mass spectrometry data enabled the identification of potential targets, which we intend to investigate further.Simultaneously, I am engaged in characterizing constrained peptides that target either LRRK2 or key components within its downstream signaling pathways.Moreover, I have sustained collaboration with my former supervisor on a shared project. Our focus is examining the in vitro seeding patterns of alpha-synuclein, specifically aiming to analyze the post-translational modifications (PTMs) of this protein using cerebrospinal fluid (CSF) samples obtained from Parkinson's disease (PD) patients. Show less

Tübingen, Baden-Württemberg, Germany

Translational Biomarkers in Neurodegenerative Diseases - Priv.-Doz. Dr. Christian Johannes Gloeckner, Prof. Dr. Thomas GasserDuring my last position as postdoctoral researcher, I was involved in an industrial project, testing in vitro new potential LRRK2 inhibitors within the treatment of Parkinson’s disease. I have also been working on the LRRK2 interactome via proximity labelling, to better understand its biology and its possible implication in the development of Parkinson’s Disease.

Reutlingen, Baden-Württemberg, Germany

Neuro Microphysiological Systems group - Dr. Paolo CesareDuring my time at the NMI, I worked on my PhD project (Modelling Neuron-Glia Networks into a drug discovery platform for Pain Efficacious Treatments), a European project financed by the Innovative Medicine Initiative (IMI) under the name NGN-PET (ngn-pet.com). My main tasks involved the isolation and culture of primary sensory neurons from murine cells on microelectrode arrays (MEA) and microfluidics-microelectrode arrays… Show more Neuro Microphysiological Systems group - Dr. Paolo CesareDuring my time at the NMI, I worked on my PhD project (Modelling Neuron-Glia Networks into a drug discovery platform for Pain Efficacious Treatments), a European project financed by the Innovative Medicine Initiative (IMI) under the name NGN-PET (ngn-pet.com). My main tasks involved the isolation and culture of primary sensory neurons from murine cells on microelectrode arrays (MEA) and microfluidics-microelectrode arrays (MF-MEA), to analyse the contribution of glia cells in neuronal excitability in the peripheral nervous system, and how this can contribute to the development of pain states. Along with my scientific tasks, I was also responsible for distributing duties in the lab and animal facility among group members and managing invoices. Show less

Reutlingen, Baden-Württemberg, Germany

After finishing my Master's Degree in Pharmaceutical Biotechnology, I started working as a Research Assistant in neuroscience. I learned the main biological techniques that I later used in my PhD, including primary cell culture and electrophysiology analysis on microelectrode arrays (MEA).I also attended intensive German classes to improve my German.

Doctor Of Philosophy - Phd, Cellular And Molecular Neuroscience

Co-culturing sensory neurons and glial cells on microelectrode arrays platforms for functional studies on pain.

Erasmus Exchange Program, Pharmaceutical Biotechnologies

In-vitro metabolism of novel kinase inhibitors and analysis through LC-MS

Master'S Degree, Pharmaceutical Biotechnologies

Bachelor'S Degree, Biotechnologies