Francesco Cacciante, Phd Email & Phone Number

Siena, Toscana, Italia

Siena, Toscana, Italia

Pisa, Tuscany, Italy

I am testing a Gene Therapy approach in order to cure a rare genetic disorder. I introduced and optimized an injection technique in my lab which allowed to cut the injection time by 90% and increase the positive outcome of injections to 100%, dramatically increasing the feasibility of our approach.Examining the clinical data of patients, I was able to confirm also in humans, the viability of our previously found biomarkers.

Pisa, Italia

• Responsible for the “Congenital creatine transporter disorder (CTD): insight into new therapeutic preclinical strategies” project.• Designed and conducted experiments in order to characterize the murine model of the pathology and identify biomarkers.• Evaluated two different preclinical trials.• Performed in-vivo ed ex-vivo surgeries.• Set up protocols to gather and analyze various kind of data (EEG, microscopy, behavior, molecular)• Gathered and analyzed data from human patients and confronted with data obtained from murine model of CTD.• Developed and genotyped genetically modified mice to evaluate cell-specific alterations.• Responsible for experimental animals housing, care, and genotyping, up to 6 different lines.• Responsible for managing, mentoring and advising trainee and students on topics such as study design, data analysis and academic writing.• Delivered high-impact peer-reviewed publications by successfully collaborating with colleagues from multiple disciplines.

Pisa

Training in different microscopy techniques for evaluation of dendritic spines plasticity.In vivo 2-photon microscopy, confocal microscopy, dendritic spines plasticity, plasticitymarkers.

Pisa Area, Italy

"Cortical plasticity in the primary visual cortex during development: Epigenetic mechanisms in a murine model of monocular deprivation"Epigenetic regulation, miRNAs, PCR, rt-PCR, real-time PCR, ChIP, monocular deprivation.

Master Of Science - Ms, Data Science, 110 Cum Laude

Doctor Of Philosophy - Phd, Neuroscience, 70/70 Cum Laude

My PhD course focuses on the characterization of a rare genetic disorder (Creatine transporter deficiency syndrome) and possible.

Laurea Magistrale Lm, Molecular Biology, 110/110 Cum Laude

Laurea Breve, Biology, General, 110