Francesco De Chiara Email & Phone Number

Granollers, Ct, Es

Granollers, Ct, Es

Granollers, Ct, Es

Leiden, South Holland, Netherlands

Innovation: Driving innovation in RNA editing technologies, approaches, and therapeutic applications. Deep understanding of Drug intelligence discovery that leverages data analysis and AI to identify potential new pharmaceutical compounds and accelerate drug development. Implementing innovative strategies within the company. Research Leadership: Providing direction and oversight for the company's scientific research, ensuring it aligns with its strategic objectives. This includes developing and implementing research strategies and methodologies. Project Management: Directing and managing scientific projects, which include the development and optimization of RNA editing technologies, preclinical studies, clinical trials, and regulatory submissions. Collaboration and Partnership: Collaborating with other departments within the company, as well as external partners, to facilitate the translation of scientific discoveries into therapeutic applications. Regulatory Compliance: Ensuring the company's scientific activities comply with relevant regulatory standards and ethical guidelines. This may involve working closely with the company's regulatory affairs and quality assurance teams. Communication: Communicating the scientific progress to leadership, investors, regulators, and the scientific community via reports, presentations, and research publications. Budget Management: Overseeing the budget for research and development activities, making sure that resources are used effectively and efficiently. Defining the strategy and objectives for digital transformation, ensuring alignment with the company's vision and goals in RNA editing innovation. Implementing internal digital platforms to promote innovative projects in therapeutic areas and managing the digital transformation project portfolio.

Barcelona Area, Spain

Bridging the gap between research and development (R&D) and marketing teams, transforming analytical insights into actionable strategies that drive business growth. Leading effective implementation of new technologies in drug discovery and development through partnerships with international pharmaceutical companies.Coordinating projects between R&D, regulatory, clinical operations, and marketing teams to revolutionize drug discovery and development, benefiting patients and healthcare providers worldwide.As a project manager, key achievements include:Serving as the primary point of contact for clients, demonstrating strong customer focus, and fostering relationships with client project teams. This approach has led to the successful completion of goals within record timeframes.Developing project plans and schedules to ensure timely achievement of milestones. This includes conducting kick-off meetings and coordinating cross-functional teamwork among R&D, technical support, supply chain, quality operations, design quality, regulatory affairs, and marketing teams.Notable projects led and coordinated include:"Non-alcoholic fatty liver disease as a cause of sarcopenia""Micro-l-AI-ver: Artificial intelligence-powered drug screening platform for 3D-bioprinted human liver microspheres""AI-powered assistant for the real-time detection of depression"As a principal scientist, key achievements include:Securing the Knowledge Industry Programme 201 grant from AGAUR for the BioLiver Assist Device (BLAD) project. The primary objective of this project is to complete the in vitro validation of the artificial liver.Obtaining the 7th call CERCAGínjol Patents Fund for the Uniink project, reflecting the innovative potential of the research.Securing an international multi-layered Cell Capsules for Cell Implantation (PCT patent filed on September 10th, 2019, P5043PC00 to European Patent Office).

Barcelona Area, Spain

As an External Scientific Collaboration Manager in R&D, I controlled the overall process for external scientific collaborations, ensuring compliance with SOPs, and maximizing value delivery. My experience included managing interactions with external scientific partners, sharing responsibility for project execution and delivery, and working within a cross-functional matrix setting.Key Responsibilities and Achievements:Single point of contact for assigned External Scientific Collaborations, streamlining communication and ensuring effective stakeholder coordination.Engaged with Business Owners to secure strategic intent and alignment for new collaboration requests, ultimately obtaining Leadership team approval.Spearheaded coordination with supporting functions, ensuring timely information collection and implementation of project steps according to written standards.Developed a comprehensive understanding of cost drivers in external collaborations, reviewing budget requests from external collaborators to optimize resource allocation.Monitored collaboration execution, identified potential risks, and implemented preventive or mitigation measures in coordination with Partners and Business Owners.Collaborated with contracting teams to trigger amendments/revisions as needed, maintaining compliance with contractual terms.Contributed to leadership reporting and established efficient procedures to comply with audit requests, maintaining a high level of transparency.Acted as Primary Point of Contact for collaborations, fostering effective working relationships and facilitating communication between internal and external parties.Worked closely with external partners, Business Owners/Project Leads, and other key stakeholders (e.g., BD, IP, Legal) to achieve mutual strategic objectives and continuously generate value within collaborations.

London, Greater London, United Kingdom

I specialized in investigating innovative treatment strategies, conducting comprehensive data analyses, and delivering value-driving solutions to clients in various stages of analytics maturity.Key Projects and Expertise:Investigated Yaq-001 as a therapeutic strategy for Acute-on-Chronic Liver Failure (ACLF) and Non-alcoholic Liver Steatohepatitis (NASH), contributing to the advancement of liver disease treatment options.Conducted RNA-seq analysis on human and animal liver samples using cutting-edge technology, such as Illumina HiSeq, Roche 454, and SOLiD equipment, ensuring high-quality data for further analysis.Performed differential gene expression analysis using RStudio, identifying dysregulated processes and potential therapeutic targets in liver disease.Utilized QIAGEN Ingenuity Pathway Analysis (IPA) to explore dysregulated pathways, enhancing the understanding of underlying molecular mechanisms in liver diseases.Confirmed the results of RNA-seq and pathway analyses using qPCR with Taqman chemistry, validating the accuracy and reliability of the findings.Key Achievements:Successfully shaped, presented, and delivered analytic solutions for clients at various stages of analytics maturity, demonstrating adaptability and a commitment to client satisfaction.Established a proven track record of delivering pragmatic and value-driving solutions, contributing to the progress of liver disease research and therapeutic development.I was committed to understanding liver disease mechanisms and contributing to the development of novel therapeutic strategies. My experience in advanced data analysis techniques, combined with a strong scientific background, enables me to deliver high-quality, value-driven solutions for clients in the field of liver disease research.

London, United Kingdom

Associate Scientist: Leader of the project “Ammonia as target for treatment in patients with Acute-on-Chronic liver failure”. Grant proposal writing (from cover letter to budget). Operates specialized scientific instrumentation. Performs statistical analyses, including selecting the appropriate analysis procedure and, setting up data for analysis. Optimization of experimental procedures. Effectively uses available technology to help the success of the project. Establishing priorities and recommending schedules, timetables, and costs. Tutoring junior’s lab members.

London, United Kingdom

Project: "Effects of ammonia and OCR-002 on primary human hepatic stellate cells".Performed task:- UK clinical research regulation;- Investigators responsibilities;- Identify key tasks in the informed consent process;- Report & record adverse events;- Ensure compliance with the Data Protection Act.Performed laboratory task: - Isolation and propagation of human and rat primary liver cell populations.- Cell proliferation and metabolic assays.- Light and scanning electron microscopy.- Immunoassays-- Gene and protein assessment and quantification.

Naples, Campania, Italy

DutiesMy PhD research was focused on the importance of human genetic resistance against the infection of Mycobacterium tuberculosis. Manipulation, storage, and processing of human blood samples from patients with pulmonary tuberculosis from collaboration with Monaldi Hospital, reference centre for tuberculosis in Italy. Genetic and epigenetic analysis of single nucleotide polymorphisms of two genes, MyD88 and TIRAP, involved in the immune response to the Mycobacterium tuberculosis.Statistical analyses including the calculation of ODDs ratio using Fisher’s exact test between control and cases, sample size, Hardy–Weinberg equilibrium, Mantel–Haenszel test, logistic regression analysis coupled with bootstrap resampling, Generalized Linear Model procedure, and the univariate ANOVA with Tuckey’s HSD post hoc test. AchievementsI defended my PhD thesis after 3 years of research. I have published 3 scientific articles as second author.

Master'S Degree, Big Data & Business Analytics

Comprehensive knowledge and skills: The program provided me with in-depth knowledge of big data and data analytics techniques, tools.

Short-Course, Clinical Research Associate

Activities and Societies: - Roles and Responsibilities in Clinical Research - Trial Oversight Committees - Informed Consent in Research.

Doctor Of Philosophy - Phd, Biological Sciences

Activities and Societies: Project: Identify disease-associated single polymorphisms nucleotide (SNP) implicated in human pulmonary.

Master'S Degree (M.Sc) In Resource Marine Biology, Applied Biology, 110/110

Activities and Societies: Grade: 110/110 Technical course: Expert in the management of environmental monitoring using GIS platform" ID.

Bachelor'S Degree (Bsc) In Biological Sciences, Biology/Biological Sciences, General, 106/110

Activities and Societies: Technical Career Education Program:"Water resources systems planning and management". Excellence in Government.