Giovanni Crisafulli Email & Phone Number

I'm a bioinformatics manager and computational researcher at IFOM ETS – The AIRC Institute of Molecular Oncology and my fields of research are Genetics, Bioinformatics, Oncology, Molecular Genetics and Precision Medicine. I have worked in the private and public sectors. I gathered excellent skills in Bioinformatics, Systems Biology, Oncology, Molecular Genetics and analysis of NGS data. I contributed to different projects: 1) Monitoring clonal evolution dynamics and the emerging of new resistant clone to therapy using liquid biopsy in CRC (Crisafulli et al., ESMO open 2019, Siravegna G, Lazzari L, Crisafulli G -- co-first author -- et al., Cancer Cell. 2018, Van Emburgh BO et al, Nat Commun. 2016) and breast cancer (Siravegna et al., ESMO open 2017), traslating discoveries in clinics (Sartore-Bianchi et al. Nature Med 2022). 2) Understanding genetic processes such as adaptive mutability. Using NGS data of samples and cell models from CRC, we understood that cancer cells can adapt to therapeutic pressures by enhancing their mutability (Russo et al., Science 2019, Russo et al. Nat Genetics 2022). 3) Discovering a new biomarker to use in precision medicine: the number of mutations/neoantigens, linked to Tumor Load, can guide the therapy in colorectal cancer. High Tumor Load tumors can improve immune surveillance and are required for effective immunotherapy response (Germano et al. Nature 2017, Pinocchino, Crisafulli et al. Cancers 2021) and these results could be translated in clinics as showed in ARETHUSA clinical trial (Crisafulli et al. Cancer Discovery 2022).

Listed skills include Ricerca, Research, Bioinformatics, Systems Biology, and 6 others.

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  Computational Scientist - Bioinformatics Manager At Ifom

  Ifom

  Milan, It