Gary Geiss Email and Phone Number
I am a scientist and team leader with 18 years of inventing and commercializing breakthrough molecular barcoding assays. I have a proven track record of 'getting stuff done', solving the challenges of early product development and working with customers on commercial applications of the technology. With experience of launching three multiplexing platforms, I have deep understanding on the processes required to integrate molecular assays with both instruments and software to form a successful product. My specific expertise covers a diverse range of nucleic acid and protein analytes and applied to both bulk measurements and spatial biology contexts. . As Senior Director-Research I have built motivated and cross-functional teams that work together to deliver on the strategic roadmap and scientific vision of the company. I strive to be a respected and trusted leader that leads by example and communicates clearly with my team and others. This approach has helped launch more than a dozen products across multiple barcoding platforms.Things I enjoy doing successfully:• Solving scientific problems that lead to commercial products.• Helping customers with the design and application of company products to answer scientific questions.• Building and managing motivated and cross-functional teams that make robust assays.• Working collaboratively with product development, manufacturing, marketing, and research teams to launch novel multiplexed platforms.• Designing and integrating molecular assays to work with instrument hardware, software, and analysis tools. • Developing and delivering long-term strategic roadmaps, resource planning and product release schedules.• Communicating company technology to early adopters, influential customers, commercial partners, and internal support staff. • Thriving in a faced-paced, dynamic company culture where cross-functional teams work synergistically to build new breakthrough technologies.
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Product Development And Strategy ManagerMonod BioSeattle, Wa, Us -
Sr. Director Of R & DParse Biosciences Feb 2024 - PresentSeattle, Washington, United States -
Senior Director - Research-Spatial Protein And Multi-Omic AssaysNanostring Technologies, Inc. Oct 2019 - Dec 2023Seattle, Washington, United States• Senior Leader responsible for the scientific design, strategic planning, and commercial launch for all spatial protein assays for both the digital spatial profiling (GeoMx) and spatial molecular imaging (CosMx) platforms• Built a motivated team of Ph.D. and supporting scientists that developed, manufactured, and tested protein detection assays and spatial biology analysis methods and software.• Led strategic relationships for protein-focused commercial partners, customers, and collaborators.• Team Accomplishments: o Built and validated protein panels that make up one of the most highly-plexed spatial protein imagers in the life science market. o Modified oligo-antibody reagents to be compatible with cyclic fluorescent-based detection in our CosMx Spatial Molecular Imager. o Integrated and optimized CosMx protein assays for imaging and fluidic hardware considerations, image processing software, reagent manufacturing, and analysis algorithms. o Helped integrate and test Nanostring’s first cloud-based single-cell spatial analysis software (AtoMx™) which provided QC, normalization, cell typing, UMAPs and image viewing capabilities. o Developed and published Nanostring’s first multi-omic spatial protein and RNA assay from the same FFPE tissue sample. o Commercialized customer facing antibody conjugation kits for GeoMx based on specific spatial assay and readout specifications. -
Senior Principal Scientist-Multiplexed Rna And Protein AssaysNanostring Technologies, Inc. Jul 2015 - Oct 2019Seattle, Washington, United States• Designed and leveraged our oligo-tagged antibody approach to develop NanoString’s first spatial protein assays that led directly to the launch of the industry’s first digital spatial profiling platform (GeoMx).• Established a team responsible for implementing a system of conjugating, screening, validating, and optimizing antibodies used in GeoMx spatial products for Human and Mouse Immuno-oncology and Neurobiology. • Primary subject-matter expert for protein and nCounter detection providing key customer, sales, and marketing support.• Team accomplishments o Launched the first multi-omic product for Nanostring (3D Biology) that measured RNA, DNA and protein from the same sample in cells or FFPE tissue using nCounter barcodes. o Established a system of conjugating oligonucleotides to antibodies that was compatible with nCounter® and Next Gen Sequencing readouts. o Functionally validated oligo-antibody conjugates for binding to cell surface in solution, lysed cells in 96 well plates, and in IHC-like format on FFPE tissues mounted on slides. o Used custom designed cell pellet arrays to screen and validate large numbers of antibodies for our GeoMx DSP and 3D biology platforms. o Devised assays and wrote requirements to measure sensitivity, specificity, background, signal-to-noise, and contamination of protein reagents. o Generated collateral for benchmarking performance against ‘gold standard’ protein assays including ELISA, IHC, flow cytometry and public protein databases.
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Principal Scientist-Multiplexed Nucleic Acid ApplicationsNanostring Technologies Aug 2008 - Jul 2015Seattle, Washington, United States• Scientific lead on various teams for design and launch of multiplexed assays from FFPE tissue including RNA, DNA, miRNA, and protein that sustain the core of nCounter business today.• Communication and customer support expert who led proof-of-principle services, presented technology at customer sites and tradeshows, and guided customer-facing experiments and troubleshooting efforts.• Key early contributor to design and development of FDA approved 50-gene biomarker signature for breast cancer (Prosigna) that initiated the company’s IPO.• Familiarity with operating in ISO 13485 environment and other relevant regulatory standards (510k/FDA) • Other Accomplishments o Primary scientist in the modification and expansion of the nCounter assay for multiplexed detection of various nucleic acids including, fragmentation and denaturation (dsDNA assays), DNA/RNA ligation (miRNA), split and ‘toe-hold’ probes (Fusion/splice variants). o Developed key nCounter assays through the product development lifecycle from concept to commercialization that led to cancer CNV panels, miRNA panels, miRGE (miRNA/mRNA combo) panels that are still part of the nCounter product line. o Built a generic molecular barcoding system (Elements) using cloned tagged sequences and oligonucleotide bridges that were specifically designed for use in lab developed tests (LDTs). o Helped design, integrate and test nSolver analysis SW (Nanostring’s first data analysis solution) which provided QC, normalization, fold-change analysis and graphical representations of gene expression data.
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Sr. Scientist-Molecular Barcoding Assay DevelopmentNanostring Technologies, Inc. Feb 2005 - Aug 2008Seattle, Washington, United States• Co-inventor of molecular barcoding system and first author of seminal paper in Nature Biotechnology describing design and performance of the technology that led to commercial version of NanoString’s nCounter platform.• As employee number 12 in small start-up, ‘wore many hats’ and worked closely with a small team of PhD scientists to advance the development of the original multiplexed molecular barcoding system including instruments and imaging software• Primary scientist that lead early adoption program for customers prior to and during the launch of the nCounter system.• Other accomplishments: o Solved the key technical issues associated with two-probe hybridizations in solution, annealing of fluorescent RNAs to ssDNA, affinity purification of tripartite molecules, and binding to coated hydrogel surfaces. o Optimized sample prep and hybridization conditions to demonstrate the technology was best-in-class for quantitative measurements of degraded RNA from FFPE tissue. o Designed ideal gene sequence characteristics in collaboration with bioinformatician for two probe binding under system conditions. o First author of seminal paper in Nature Biotechnology describing design and performance of the 500 gene multiplexed RNA expression assay using molecular barcodes.
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Research Scientist-Antibody-Based BiosensorsUniversity Of Washington Sep 2003 - Jan 2005Seattle, Washington, United States• Developed antibody-based biosensors using surface plasmon resonance for detection of potential biowarfare agents (e.g., anthrax).• Worked with engineers to build prototype portable biosensor instruments. -
Sr. Scientist-Dna Microarrays-Chromatin ScreeningRegulome Inc Jul 2002 - Jun 2003Seattle, Washington, United States• Recruited to apply ink-jet DNA microarrays to screen regulatory elements in the human genome. • Used genome-wide sequencing data of regulatory elements to design probes for screening via DNA microarrays• Created hybridization probes from human chromatin preparations for use in high-throughput screening
Gary Geiss Education Details
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Virus-Host Interactions | Gene Expression Profiling
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Colorado State UniversityBiochemistry And Molecular Biology -
Biology/Biological Sciences, General
Frequently Asked Questions about Gary Geiss
What company does Gary Geiss work for?
Gary Geiss works for Monod Bio
What is Gary Geiss's role at the current company?
Gary Geiss's current role is Product Development and Strategy Manager.
What schools did Gary Geiss attend?
Gary Geiss attended University Of Washington, Colorado State University, Lock Haven University Of Pennsylvania.
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1 +181592XXXXX
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Gary Geiss
United States -
Gary Geiss
Mays Chapel, Md
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