Gaston Loo

Gaston Loo Email and Phone Number

Head of Engineering at Esco Aster @ ESCO ASTER PTE LTD
Gaston Loo's Location
Singapore, Singapore
Gaston Loo's Contact Details

Gaston Loo personal email

About Gaston Loo

"With over 25 years of extensive work experience in the pharmaceutical and automation industry in Singapore and Asia, I have developed a strong expertise in various areas. My background includes utilities systems and facilities management, project management, equipment commissioning and qualification, as well as greenfield/brownfield plant start-up for fill & finish, tablet, biologics, packaging line and CDMO operations.I have actively contributed to continuous improvement initiatives through lean six sigma programs, ensuring operational efficiency and quality. Additionally, I have led successful implementations and testing of DCS/PLC/SCADA systems, established laboratory and clean room setups, and designed HVAC systems with a focus on energy-saving initiatives.Throughout my career, I have gained valuable experience in pharmaceutical manufacturing operations and packaging line management, adhering to biosafety requirements and ensuring compliance with environmental health and safety (EHS) programs. I have also excelled in asset management lifecycle and reliability initiatives, undertaking risk assessments and effectively managing deviations and investigations.Furthermore, I possess a solid understanding of computerized system validation (CSV) and GAMP guidelines, as well as regulatory compliance such as 21CFR part 11, GLP, and GMP standards. Handling audits and maintaining regulatory compliance has been a consistent priority.I am driven by a passion for excellence in the industry, and I continuously seek opportunities to contribute my expertise and drive positive change. Let's connect and explore ways we can collaborate to achieve mutual success."Personal Attributes:- Customer service oriented - Leadership for the team- Transparency and listen to feedback - Collaboration for common goal - Team spirit and player for higher productivity - Negotiate for win-win situation - Positive and self motivation - High tolerance for ambiguity- Passion for continuous improvement - Promote spirit of innovation- Adaptation to agile environment- Communicate effectively - Inspiring ownership- Commitment and earn trust to build high performance team- Role model and leading by example

Gaston Loo's Current Company Details
ESCO ASTER PTE LTD

Esco Aster Pte Ltd

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Head of Engineering at Esco Aster
Gaston Loo Work Experience Details
  • Esco Aster Pte Ltd
    Head Of Engineering
    Esco Aster Pte Ltd Nov 2020 - Present
    Singapore, Sg
    Handle tender document for COVID-19 fill and finish brownfield facility (CDMO). Lead & finalise the layout with key equipment for the new facility (concept design). Prepare tender document and finalise scope of work to shortlist EPCM firm. Lead the due diligent assessment of the facility prior to acquisition with EPCM firm. Responsible for the site permit, license and EHS activities with various authorities and agencies (JTC, NEA, SCDF, PUB, BCA, LTA, EDB, EMA, SFA etc.) URS preparation and bid evaluation of various equipment / software / system. Establish and recruit various positions of Engineering team for the startup activities. Responsible of various ongoing project and expansion plan for the organization. Responsible to design and build the new facilities according to GMP requirement. Implementation of CMMS maintenance & calibration Blue Mountain BMRAM. Responsible of automation include CSV and BMS/EMS qualification on cleanroom. Responsible of CAPEX and OPEX maintenance budget for the organization. Major Achievement in Esco Aster (EA):Successful startup and operation of cell culture cleanroom on Jun 21 Successful startup and operation of Bio-processing R&D lab on Jul 21 Go-Live of BMRAM CMMS maintenance and calibration module on Aug 21 Successful inspection by SFA for food license of cell-cultured protein on Aug 21 Successful startup and NEBB certification of GMP DS cleanroom on Sep 21 Successful startup and operation of cell line creation (CLC) cleanroom on Oct 21 ISO22000 certification (FSM) business operation for cell-cultured protein on Nov 21 Construction completed and operation of GMP DP cleanroom on Feb22 Successful startup and operation of Suite B (GoodMeat) cleanroom on Sep 22 Successful awarding ISO 9001:2015 certification for Esco Aster on Oct 2022 Completed EA GMP facility and equipment qualification on Mar 23 Successful startup and operation of Suite C cleanroom (Meatable) on Apr 23
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  • Lonza
    Head Of Engineering
    Lonza May 2019 - Oct 2020
    Basel, Ch
    Lead, recruit and form Engineering team to support the start-up and commissioning of Lonza new biologics facility. Coordinate the transition of engineering and validation activities from start-up into routine operation for the new facility. Establish engineering resource to provide technical support to relevant to project execution, automation, maintenance/calibration, IT/OT and utilities. Establish and manage the outsourced site services such as pest control, janitorial cleaning, laundry, security services, waste handling, building maintenance, and landscaping in a state of compliance to cGMP and EHS. Ensure buildings, facilities and sites are built and delivered to fully meet expectations of cGMP, EHS, regulatory/authority requirements in alignment with Lonza Guidelines & Policy. Ensure clean utilities system is qualified, compliance and provide reliable supply with establishment of operation and maintenance procedure for entire site. Responsible for developing and implementing the maintenance strategy, calibration, and spare part in SAP in alignment with the Lonza Global engineering procedure. Responsible for annual maintenance budget, OPEX and CAPEX. Develop roadmap and roll up Lonza asset management program (LAMP) which consist different phases of asset lifecycle, reliability program, work order and etc. Embark and cultivate operational excellence mindset to Engineering team to improve routine activities and achieve efficiency. Major Achievement in Lonza:Go-Live of SAP for CMMS maintenance and calibration module on Feb 20. Recruited, established and onboard Engineering team (45 persons) on Jun 20 Completed startup task for validation team to start the IQ & OQ activities on Jul 20. PDA Singapore – speaker for “lifecycle approach to asset management” on Jul 20. Successful commissioning of modular production facility (KUBIO) on Sep 20. Successful move in and hand over of Pilot/Quality & Utilities building on Oct 20.
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  • Roche
    Head Of Maintenance And Calibration
    Roche Mar 2017 - May 2019
    Switzerland 🇨🇭 , Ch
    Establish strategic goals and objectives while maintaining full responsibility for the Maintenance and Calibration organization. As a Facility and Engineering leadership team member to drive collaboration within site and across network activities, cross-functional planning, and decision making. Accountable for overall budget and financial performance of the Maintenance and Calibration organization. Ensure all team members are competent and provided with the necessary tools and equipment to work safely and without health risks. Process optimization / development, cost-reduction initiatives and support technology transfer activities with technical team (biologics equipment). Ensure strict compliance with high standards of cGMP in all aspect of maintenance activities and documentation according to site Quality program. Embark on LPS (Lean Production System) for lean manufacturing and drive continuous improvement (Kaizen) and MTTR/MTBF. Major Achievement in Roche:Take on Cost leadership role in 2018 and work with cross functional team using Lean principal to close financial gap of CHF10.3mil and site to operate at < CHF122mil. Initiate, lead and implement Kaizen program for Facility & Engineering team with completion of 86 and 154 kaizen in year 2017 and 2018 respectively. Appointed as Chairman of Contractor Safety to promote safety culture & behavior. Optimise site maintenance spare part cost centre from US3.5mil to 2.6 mil. Zero observation for External Health Authority inspection by FDA & EMEA related to facility & maintenance in 2017 & 2018. Drive sustainability initiative through A3 and Kaizen program to reduce waste and energy consumption for the facility with > USD 200K saving in 2018. Drive and optimize contract management resulted saving of > USD 1.8mil in 2018. Drive root cause (RCA) with robust CAPA and engineering solution (e.g. Poka-Yoke) to prevent reoccurrence resulted human error & deviation reduction > 30% in 2018.
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  • Msd
    Senior Engineering Manager (Associate Director)
    Msd May 2012 - Mar 2017
    Rahway, New Jersey, Us
    Provide leadership and efficient mobilization of resources to support plant operation. Pharm West facility (May 12 till Oct14);Tablet plant:- ZETIA (ezetimibe) tablet production for "bad" cholesterol (LDL)- Nasonex production - from compounding to high speed packaging line (reduce inflammation in the nasal cavity)New Tablet greenfield new facility:- Janumet US$120mil (4 granulators and tablet compression machine)- Design phase to facility handover by EPCM LendleaseDPI plant:- Asmanex for asthma treatment Pharm South facility (PF1/PF2 /PF3 plant) and DPI (Oct 14 till Mar17). - Isentress- Vytorin for "bad" cholesterol (LDL)Responsible to resolve plant equipment reliability / performance issues. Plan and oversee all the plant shutdown maintenance activities. Responsible for OPEX and CAPEXStaff development Major Achievement in Schering-Plough & MSD: ISPE Thailand - speaker for “critical utility design and maintenance” on July 2013 Successful startup of Janumet Tablet facility (US$120 million) in 2014 Packaging line efficiency and 40% downtime reduction through Toyota KATA in 2014 Lead and implemented serialization technology for packaging production in 2014 Lead and executed South Disentanglement Project between MSD & Abbvie in 2015-2017
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  • Msd
    Pharmaceutical Maintenance Manager (Biotech)
    Msd May 2006 - May 2012
    Rahway, New Jersey, Us
    Formerly under Schering-Plough until late 2010Startup of Biotech greenfield facility from concept design (CD) - basic design (BD) - detail design (DD) with US 200mil CAPEX from year 2001. Activities include civil construction work, MEP (mechanical / electrical / Piping) installation, project management and commissioning.Went thru the entire project lifecycle of validation from URS - FDS/HDS/SDS - FAT/SAT - IQ/OQ/PQ.Technology transfer:1) Peg-Intron from Vetter (Redipen) for Hepatitis C2) Remicade (2 and 20 ml vial) from Johnson &Johnson (J&J) for rheumatoid arthritisSupport the startup of production activities on Engineering Run with cross-function team Went thru plant startup activities - established Engineering team with various disciplines (Automation, E/I, Facility/Utility, Equipment), new workshop, SOPs, Maintenance and Calibration system (Bluemountain and SAP), establish spare parts, staff skill learning & development plan.New facility - regulatory audit and inspection preparation for FDA, EMA, HSA, TGA, Mexico, etc.Lead the continuous improvement (Kaizen) activities for the new facilityMajor Achievement in Schering-Plough / MSD:Successful implementation of Y2K project. Completed the qualification of the production equipments according to validation master plan. Achieved zero observation for FDA, EMEA and HSA Audit. Manage and lead a multi-tasking Engineering team in Biotech plant resulting in saving of 30% headcount. Successful saving of $200K in year 2005 by implementing various costs saving projects Successful completed FMEA of business continuity plan for supply chain of Biotech products. ISPE Singapore - speaker for “critical utility design and maintenance” on June 2008. Successful startup / technology transfer of Remicade on vial line in 2009 Accomplished Remicade yield improvement project 2010-11 with US$3.5M saving. Winner of Everyday Use of MPS and Sigma Award 2011 (worldwide recognition)
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  • Msd
    System Specialist, E/I Engineer, Senior Control System Engineer
    Msd Mar 1999 - May 2006
    Rahway, New Jersey, Us
    Formerly under Schering-PloughFacility - API (Steroid and Synthesis), Biotech (sterile fill and finish facility)
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  • Kaba Workforce Solutions
    Field System Engineer
    Kaba Workforce Solutions May 1998 - Mar 1999
    Responsible for the designing, installing and customizing of Access and Time Attendance system in Singapore and regional.Proposal write-up and consultation work to the potential client, customized programming using C++. Conduct training to end user and proposed maintenance contract to the client. System integration and interface with other communication platform.
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  • Honeywell
    Technical Specialist
    Honeywell Mar 1995 - May 1998
    Charlotte, North Carolina, Us
    Responsible for testing & commissioning of field devices / instruments with building management system (BMS) and fire alarm system (FAS) in Singapore and regional.Provide training to end user upon completion of project. Liaise with customer in technical issues & conduct evaluation for the new project.
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Gaston Loo Skills

Management Gmp Biotechnology Continuous Improvement Capa Pharmaceutical Industry Leadership Validation Fda Aseptic Processing 21 Cfr Part 11 Computer System Validation Change Control Quality System Sop

Gaston Loo Education Details

  • University Of Central Queensland
    University Of Central Queensland
    General
  • Singapore Polytechnic
    Singapore Polytechnic
    Electronics Engineering
  • University Of Western Sydney
    University Of Western Sydney
    Information Technology

Frequently Asked Questions about Gaston Loo

What company does Gaston Loo work for?

Gaston Loo works for Esco Aster Pte Ltd

What is Gaston Loo's role at the current company?

Gaston Loo's current role is Head of Engineering at Esco Aster.

What is Gaston Loo's email address?

Gaston Loo's email address is ga****@****ail.com

What schools did Gaston Loo attend?

Gaston Loo attended University Of Central Queensland, Singapore Polytechnic, University Of Western Sydney.

What skills is Gaston Loo known for?

Gaston Loo has skills like Management, Gmp, Biotechnology, Continuous Improvement, Capa, Pharmaceutical Industry, Leadership, Validation, Fda, Aseptic Processing, 21 Cfr Part 11, Computer System Validation.

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