Gavin D'Souza Email & Phone Number

Silver Spring, Maryland, United States

Silver Spring, Maryland

Developing non-clinical methods for standardized testing of cardiovascular devices during pre-market regulatory submissions.

Cincinnati, Ohio Area

Pre-surgical planning for congenital heart disease (CHD) patients- Developing patient-specific cardiovascular models using medical imaging, image processing, and 3D printing- Pre-surgical planning using a) virtual implantation of VAD, TAH, heart valve, or graft b) mock surgery on 3D printed models- Developing a virtual reality (VR) software for virtual surgery- Population-based evaluation of mechanical circulatory support (MCS) device fit using virtual modelsOutcome: improving surgical outcomes and reducing operating time and cost for CHD patients at Children’s Hospitals across the US; enhancing the design of pediatric devicesEvaluation of pulmonary artery dysfunction in CHD patients using functional-structural diagnostic parameters and 4D MRI - Developing patient-specific in vitro phantoms using image-based modeling, computer-aided design (CAD), and 3D printing - Hemodynamic testing using: a) a benchtop system, b) MRI, and c) CFD- Validation of a 4D MRI methodology for evaluating energy-based indices in stenosed pulmonary arteries- Pulmonary artery wall characterization using MRI-catheterization and a hyperelastic material modelOutcome: improving CHD diagnosis using low-risk non-invasive modalities and comprehensive diagnostic parameters

Cincinnati, Ohio Area

Evaluation of pulmonary artery dysfunction in CHD patients using functional-structural diagnostic parameters and 4D MRI - Doctoral Dissertation research conducted in collaboration with the Cincinnati Children's Hospital Medical CenterInfluence of serial coronary stenoses on functional diagnostic parameters [M.S. Thesis] - Developed in vitro and CFD models of coronary artery blockages based on angiographic data and physiologic conditions- Assessed fluid dynamic interactions between multiple coronary artery blockages with pressure and flow data using a benchtop MCL and CFD simulations- Quantified the individual stenosis severity using current (FFR, CFR) and novel diagnostic parametersOutcome: assessed the pitfalls in current diagnostic parameters and proposed novel parameters for accurate diagnosis of serial coronary stenosesMentored 3 Graduate students and 1 Undergraduate student

Cincinnati, Oh

Formulated lecture notes, conducted theory lectures and lab experiments, assessed and graded lab reports

Silver Spring, Md

Development of a mock circulatory loop (MCL) for standardized pre-clinical testing of cardiovascular device performance- Designed and fabricated MCL components with enhanced functionality: dynamic compliance chambers, polymeric heart valves, and compliant ventricular-vascular chambers- Incorporated feedback control loop in the MCL for automated and reliable testing- Tested the MCL for robustness and reliabilityOutcome: advancing pre-clinical test methods for cardiovascular device performance, thus enabling FDA to evaluate emerging technologies during pre-market regulatory submissions

Silver Spring, Md

Evaluation of aerosol leakage through N95 respirators using image-based computational modeling and simulation- Created 3D reconstructions of facial profiles and N95 respirators from CT scans- Developed a CAD-based algorithm to identify aerosol leak sites and quantify gap surface area - Developed a multi-scale CFD model for quantifying aerosol leakage around respiratorsOutcome: contributed to FDA’s development of a risk assessment model to determine the risk during a public health emergency in the presence of personal protective equipment

Silver Spring, Md

Evaluation of existing verification and validation (V&V 20) standards for the modeling and simulation of medical devices using CFD- Developed a CFD model to simulate flow through the benchmark FDA nozzle- Verification: quantified the numerical error in the solution using Grid Convergence Index (GCI)- Validation: estimated the solution error accrued due to uncertainty in model dimensions, fluid properties, and boundary conditions using Sensitivity Analysis for uncertainty quantification- Evaluated shear stress-based blood damage models using the verified and validated CFD nozzle model and Lagrangian-Eulerian formulationsOutcome: obtained benchmark results for the development of the V&V 40 standards for medical devices

Cincinnati, Ohio Area

- Conducted classes and assisted students in the design and execution of course projects- Prepared lecture notes and exam material along with conducting and grading exams

Doctor Of Philosophy - Phd, Mechanical Engineering

Master Of Science (M.S.), Mechanical Engineering

M.S. Thesis - Influence of serial coronary stenoses on coronary diagnostic parameters: CFD analysis and In-vitro tests

Bachelor Of Engineering (B.E.), Mechanical Engineering, First Class