Gavin Whissell Email & Phone Number

Belmont, Ma, Us

Watertown, Ma, Us

• Led biology efforts in multidisciplinary drug discovery teams, advancing discovery of small molecules targeting E3 ligases for oncology and immunology.• Championed innovative proximity-based medicine approaches and technology developments.• Designed and implemented multiple biological assays to enhance compound structure-activity relationships (SAR).• Spearheaded multidisciplinary collaborations to conduct proof-of-concept experiments and disease modeling, driving drug discovery efforts forward.• Designed and executed LO cascade strategies, designing, optimizing and employing cellular assays to optimize lead compounds.• Coordinated internal and external activities with CROs, ensuring alignment with project timelines and goals.• Participated in discussions with KOLs to refine disease hypotheses and translational models.

Watertown, Ma, Us

• Explored and identified high value tissue restrictive and broadly function E3 ligases for potential TPD applications in oncology, immunology and rare genetic disease. • Spearheaded the discovery and validation of novel molecular glue therapeutics• Managed junior scientists, fostering professional development and a collaborative team environment.

Cambridge, Massachusetts, Us

• Progressed through roles in a dynamic startup environment, leading a new team focused on small molecule and antisense oligonucleotide therapeutics for rare genetic diseases.• Key contributor in transitioning therapeutic modality to improve specificity against targets of interest.• Established a team responsible for supporting early-stage candidates and pipeline programs.

Cambridge, Massachusetts, Us

• Championed the advancement of three disease programs, successfully transitioning one to clinical trials.• Participated in the identification of disease-relevant proteins and established proof-of-concept biological assessments of druggability.

Cambridge, Massachusetts, Us

• Led a team in establishing novel cellular assays involving iPSC and blood cell engineering and differentiation to support the company's first preclinical program.• Trained and mentored junior team members.

Cambridge, Ma, Us

• Designed and executed biology experiments for the identification and validation of novel drug targets, utilizing advanced technologies including CRISPR/Cas9 and iPSC methodologies.• Led efforts in the dedifferentiation and differentiation of CD34+ hematopoietic stem cells to support drug discovery initiatives.• Successfully advanced an early exploratory target to a validated program within two years, contributing significantly to the company’s research portfolio.• Collaborated closely with cross-functional teams to ensure alignment on project goals and timelines.

Barcelona, Es

• Project Title: WNT Signaling, Hypoxia, and GATA6: Their Role in Colorectal Cancer• Identified a gene regulating key signaling pathways in tumor initiation, contributing to research published in Nature Cell Biology (2014).

Ottawa, Ontario, Ca

• Project Title: Merging Metagenomic and Microarray Technologies• Developed a novel microarray platform for identifying genes involved in bioremediation of petroleum-contaminated soils.

Phd, Biomedicine

Msc, Microbiology

Bsc, Biology