un centro didattico scientifico che opera attraverso una serie di esperti in materie scientifiche ed umanistiche per promuovere l’educazione scientifica in modo piacevole e informale

Insegnate per le classi di concorso A059-A060

Associazione culturale che ha l'obbiettivo di diffondere il valore della conservazione della biodiversità in un ambiente, lo zoo, che diventa punto di riferimento per conoscere e imparare a conservare la Natura

Data manager Lymphoma group (Dr Rigacci)• Monitoring and data entry of clinical and laboratory protocols, national and international GCP.

Dip. di Area Critica Medico Chirurgica D.D. n. 24/2012 (prot. 164 class. VII/1) “GESTIONE PROTOCOLLI IN GCP (GOOD CLINICAL PRACTICE)”

From 15 october 2010 postgraduate scholarship entitled "Monitoring Activity within a clinical case-control study of severe acute liver injury iatrogenic" held at the Department of Preclinical and Clinical Pharmacology 'Mario Aiazzi Mancini ".

•From July 2010 to February2011 Training Project frequent volunteer at the SOD of Hematology (Director Prof. Bosi); educational objective: Management database running lymphomas and statistical analysis of selected case studies, learning contents include statistics for evaluating survival of patients diagnosed with lymphoma (tutor: dr. Rigacci). • Report on the database and log lymphomas lymphomas Lymphomas Tuscan Group (GTL) and Italian Lymphoma Intergroup (IIL)• Monitoring and data entry of clinical and laboratory protocols, national and international GCP.• Monitoring and data entry of clinical and laboratory protocols spontaneous and observational Italian Lymphoma Intergroup

-Research for Matched Unrelated Donor (MUD). -Constant database updating to European Database Registry (PROMISE) and to GITMO (Italian group). Essential for the accreditation of the Centre.-Manager for the Clinical TMO Trials

Publications, all available upon request:• Safety and efficacy reducing granulocyte colony-stimulating factors (G-CSF) in R-CHOP14 schema. Puccini B., Rigacci L., Benelli G., Alterini R. , Donnini I., Carrai V., Bosi A.; Congresso SIE 2009 (Milano, Ottobre 2009)• Efficacy of 18F-Fluorodeoxyglucose positron emission tomography (FDG-PET) at the end of therapy in diffuse large B cell lymphoma (DLBCL) to define complete remission (CR). Puccini B., Rigacci L., Benelli G., Alterini R. , Donnini I., Carrai V., Bosi A.; Congresso SIE 2009 (Milano, Ottobre 2009)• Dasatinib?: optimal bridge to stem cell transplant in chronic myeloid leukemia blast crisis (CML-BC). Gozzini A, Guidi S, Santini V., Nozzoli C., Bartolozzi B., Saccardi R., Scappini B., Benelli G., Bosi A.; Congresso SIE 2009 (Milano, Ottobre 2009)

Ph.D. (cycle XXII) identification number: DTO 5096 under graduate school of Sciences and Biomolecular and Morphogenic Technology of Florence); Title of thesis: “Effects of an anti -TNFα therapy in joint inflammation and IBD in the HLA-B27 transgenic rat model of human spondyloarthritis (SPA)”. The discoveries are now compared with the prior art? and the possible market value for a patent application. In fact these studies on anti-TNFα therapy are a topic of interest for the pharmaceutical industry.

• Interleukin-33 and its receptor ST2 may serve as an ‘alarm’? system of the progressive damage to the skin and visceral organs of Systemic Sclerosis (SSC) patients; Clinical and Experimental Rheumatology;1st Systemic Sclerosis Word Congress, Florence, 11-13/2/2010• Evidence for the prevention of enthesitis in HLA-B27/hβ2m transgenic rats treated with a monoclonal antibody against TNFα) Milia A.F., Ibba-Manneschi L., Manetti M., Benelli G., Generini S., Messerini L., Matucci-Cerinic M. J. Cell. Mol. Med. 2009; published online 8 December 2009; doi:10.1111/j.1582-4934.2009.00984.x. (I.F. 5.114)• The IL-1-like cytokine IL-33 and its receptor ST2 are abnormally expressed in the affected skin and visceral organs of patients with systemic sclerosis. Manetti M., Ibba-Manneschi L., Liakouli V., Guiducci S., Milia A.F., Benelli G., Marrelli A., Conforti M.L., Romano E., Giacomelli R., Matucci-Cerinic M., Cipriani P. Ann. Rheum. Dis. 2009; published online 23 September 2009; doi:10.1136/ard.2009.119321. (I.F. 7.188)• HLA-B27 transgenic rat: an animal model mimicking gut and joint involvement in human spondyloarthritides. Milia A.F., Ibba-Manneschi L., Manetti M., Benelli G., Messerini L., Matucci-Cerinic M. Ann. N. Y. Acad. Sci. 2009;1173:570-574. (I.F. 2.303)

• A monoclonal antibody against TNF-alpha reduces inflammation in the HLA-b27 transgenic rat model of human SPA, Benelli G., Milia A.F., Ibba-Manneschi L., Manetti M., Generini S., Messerini L., Matucci-Cerinic M. 63° Congresso nazionale della Società Italiana di Anatomia, Torino, 10-12 September 2009• TNFa blockade prevents the development of inflammatory bowel disease in HLA-B27 transgenic rats; A-F. Milia, M. Manetti, S. Generini, L. Polidori, G. Benelli, M. Cinelli, L. Messerini, L. Ibba- Manneschi, M. Matucci-Cerinic; J. Cell. Mol. Med; 2009;13:164-176• Anti-TNFa therapy prevents the development of joint inflammation in HLAB27+hβ2m transgenic rats; A-F. Milia, L. Ibba-Manneschi, M. Manetti, G. Benelli, S. Generini, L. Messerini, M. Matucci- Cerinic; submitted• Severe fibrotic changes and altered expression of angiogenic factors in maternal scleroderma: placental findings. Ibba-Manneschi L., Manetti M., Milia A.F., Miniati I., Benelli G., Guiducci S., Mecacci F., Mello G., Di Lollo S., Matucci-Cerinic M. Dis. 2009; published online 30 March 2009; doi:10.1136/ard.2009.107623. (I.F. 7.188)• TNF-Alpha antibody reduces joint inflammation in HLA-B27/HBETA2M transgenic rat model of human spondyloarthritis (SPA). A.F.Milia, L. Ibba-Manneschi, M. Manetti, S. Generini, G. Benelli, L.Messerini, M. Matucci- Cerinic. 3° European Workshop on Immune- Mediated Inflammatory Diseases. London 8-10 October 2008• Severe fibrotic changes and altered expression of angiogenic factors in maternal scleroderma. L. Ibba-Manneschi, M. Manetti, A-F. Milia, G. Benelli, I. Miniati, Federico Mecacci, S. Di Lollo, M. Matucci-Cerinic. 62°Congresso Nazionale della Società Italiana di Anatomia, Verona, 14-16 September 2008.

OPENLAB planner and technician: Teacher of biology (biotechnology and genetics) supported by experiments (from primary to high school levels)