Gianluca Frera Email & Phone Number

Rho, Lombardy, Italy

Cambridge, England, United Kingdom

– Development and optimization of cellular and biochemical assays for the validation of compounds able to induce targeted protein degradation– Screening of molecules using low- and medium-throughput techniques and preparation of work packages to enable evaluation of project progression– Biology lead for two early-stage programs with constant collaboration.

Biocity, Chapelhall, Motherwell, Scotland

Biocity, Chapelhall, Motherwell, Scotland

Oxford, United Kingdom

– Characterization of ubiquitin modifications involved in the regulation of innate immune pathways – Production and application of linkage-specific TUBEs for the enrichment of ubiquitinated proteins– Development of a new biochemical technique for the purification and proteomic analysis of ubiquitin chains on target proteins

Lausanne Area, Svizzera

– Selection and in vitro differentiation of adipocyte-derived stem cells from fat tissue explants in respect of GMP standards for their clinical application– Collaboration with an industrial partner for the commercialization of a human-derived cell culture supplement– Analyzing the properties of a novel cell culture media by cell-based assays, i.e. ELISA.

Lausanne Area, Svizzera

– Identified cellular targets for the HIV protease inhibitors and discovered molecular mechanisms of inflammasome activation– Developed and optimized cell-based assays for protein characterization and drug target validation– Gained extensive experience in sterile cell culture of human, mouse and insect cell lines– Established successful research.

– Identified alterations in the sphingolipid metabolism in ovarian cancer cells resistant to a chemotherapeutic drug – Performed protein and lipid labeling for the quantitative analysis of the observed cellular alterations– Assisted in the preparation of an article for publication in leading scientific journals

Little Rock, Arkansas, Stati Uniti

− Generated stable cell lines from tumor samples obtained from cancer patients– Investigated the expression of gynecologic tumoral markers to study the sensitivity to chemotherapeutic drugs– Investigated the role of Connexin-43 in the survival of bisphosphonate-treated osteoblasts – Maintained a constant direct communication between the clinical.

– Identified mutations in patients with rare genetic diseases

Doctor Of Philosophy (Ph.D.), Life Sciences (Cancer And Imunology)

Medical Biotechnology And Molecular Medicine, Biotechnology, 110/110 Summa Cum Laude

Biotechnology, Biotechnology, 107/110