* Comprehensive profiling of glioblastoma-infiltrating immune cell subtypes, estimation of CD8+ T cell differentiation states and trajectories, and inference of cell-cell signaling networks within the tumor microenvironment through analysis of single-cell RNA sequencing data from murine models and patient-derived samples.* Characterized model of adaptive immune resistance within the glioblastoma microenvironment after combined dendritic cell vaccination and PD-1 blockade due to… Show more * Comprehensive profiling of glioblastoma-infiltrating immune cell subtypes, estimation of CD8+ T cell differentiation states and trajectories, and inference of cell-cell signaling networks within the tumor microenvironment through analysis of single-cell RNA sequencing data from murine models and patient-derived samples.* Characterized model of adaptive immune resistance within the glioblastoma microenvironment after combined dendritic cell vaccination and PD-1 blockade due to interferon-stimulated macrophages engaging activated anti-tumor CD8+ T cells through immune checkpoints to induce their exhaustion.* Developed a gene signature for identifying tumor-reactive CD8+ T cell clones from glioblastoma clinical samples treated with and without prior immunotherapy via single-cell paired transcriptome and T cell receptor sequencing.* Facilitated patient-derived and murine T cell-tumor cell co-cultures for T cell immunophenotyping and cytotoxicity assays.* Provide computational guidance and perform customized analyses for other lab members and collaborators. Show less

* 1 of 13 out of 900+ applicants accepted to research mentorship program with scholarship funding. * Analyzed single-nucleus RNA sequencing data from human brain tissue autopsied from patients with a mutation associated with early-onset Alzheimer’s disease.* Identified transcriptional states associated with neurodegenerative disease in heterogeneous microglia and astrocyte populations.