Giovanni Nitti, Ph.D. M.S. Email and Phone Number

The Medical Lead for Gynecologic Oncology is a pivotal role within the Women's Cancer Franchise. This position demands a high level of medical expertise and strategic thinking to ensure the medical accuracy and ethical dissemination of information. The key responsibilities include providing medical leadership to the Core Medical Team, ensuring the integrity of promotional and educational materials, and fostering relationships with key stakeholders, such as advocacy groups, payers, and healthcare providers. Furthermore, the Medical Lead plays a crucial role in safety monitoring, collaborating with Patient Safety physicians, and supporting the Medical Science Liaisons and National Clinical Account Managers. By working closely with the Clinical Value Team, the Medical Lead also contributes to the design and execution of health economics and outcomes research studies.

This role demands a dual focus, encompassing both global and local (US) responsibilities.Global Focus:The role involves strategic partnerships with key global oncology stakeholders, including cancer sites, cooperative groups, and national cancer bodies. By leveraging these relationships, the individual will drive scientific engagement to fuel therapeutic area growth. This necessitates cross-functional collaboration with internal and external stakeholders to ensure alignment and support external engagement. The individual will be responsible for planning, budgeting, and overseeing external activities while adhering to compliance and regulatory guidelines.Regional (US) Focus:The role entails developing strategic clinical trial plans, fostering collaborations with NCI and NCTN, and ensuring timely updates on evidence generation activities. Additionally, the role requires operational support, including contract negotiations, liaising with internal operational stakeholders, and coordinating with field medical teams to engage with individual centers and investigators.

In addition to my past duties, I am now:- US Oncology MSL lead- NRG MSL lead- MSL lead on pivotal global clinical trial

The role involves building relationships with key customers, particularly those with scientific expertise and business knowledge. This includes engaging with healthcare providers and identifying potential study investigators. Additionally, the role required to be responsible for providing accurate and timely clinical and scientific information to internal and external stakeholders, supporting the appropriate use of products and services. in the position it is crucial staying up-to-date on disease state management, emerging therapies, and the competitive landscape. Finally, this role will contribute to the development and execution of the Alliance Research Plan, working collaboratively with cross-functional teams.

Coordinating and overseeing the proper conduction of sponsored and investigator-initiated clinical trials involves managing and overseeing clinical trials. Key responsibilities include screening, enrolling, and consenting patients for clinical trials, collecting, documenting, and analyzing clinical research data, adhering to regulatory guidelines and reporting to IRBs and regulatory agencies, liaising with various stakeholders, including physicians, nurses, pharmaceutical companies, and study monitors, as well as planning, executing, and reporting on clinical trials, including follow-up care and scientific publications.

The role involved researching the potential to enhance the effectiveness of small molecule inhibitors targeting the PI3K/AKT pathway in bladder cancer treatment by inhibiting autophagy. This research thesis aimed to induce a cytotoxic response in cancer cells, leading to their death. Successfully managed research projects, collaborated with pharmaceutical companies, mentored students, and published 5 scientific papers in the Oncology field.

Involved in three main projects regarding Human Immunodeficiency Virus (HIV), Alzheimer disease (AD) and Hepatitis C Virus (HCV) and associated with cloning, expression and characterization of catalytic antibodies of clinic interest• Planned and delivered critical data that positively impacted several publications• Provided critical technical know-how that helped improving lab’s productivity• Gained valuable experience in managing orders and lab organization• Published a co-authorship in Journal of Biochemistry

Involved in three main projects on Human Immunodeficiency Virus (HIV), Hepatitis C Virus (HCV) and the prevention of the formation of coronary atherosclerotic plaques.• Handled production & administration of monoclonal anti-idiotypes in rabbits as potential vaccine for HIV that resulted in a publication as co-author in PLoS ONE • Characterized the neutralizing potential of several antibodies for the treatment of HIV and HCV that resulted in a second publication as co-author in PLoS ONE• Provided major contribution in screening peptide libraries for the study of Antigen-drive evolution of B lymphocytes in coronary atherosclerotic plaques, published after my departure from the lab