Gleb Martovetsky, Ph.D. Email & Phone Number

San Diego, California, United States

San Diego, California, United States

Research and development of genomic, epigenetic and proteomic assays for early cancer detection

Carlsbad, California, United States

• Scientific lead of novel single cell technology assay development
• Oversee team of two scientists
• Guide bioinformatics team in evaluation of assay performance
• Stay on top of current literature to identify emerging trends and guide development efforts

Greater San Diego Area

• Scientific lead of epigenetic assay development, including scATAC-seq, ATAC-seq, HiC, RRBS, histone PTM analysis by mass spectrometry, and ChIP-seq
• Established RRBS protocol and independently prototyped entire bioinformatics pipeline
• Optimized scATAC-seq and bulk ATAC-seq protocol, developed modifications to process difficult samples, analyzed resulting datasets, and worked with bioinformatics scientists to establish analysis pipelines
• Provide scientific guidance for all of our epigenetic services assays, including ATAC-seq, RRBS, Mod Spec ® (analysis of histone PTMs by mass spectrometry), RNA-seq, targeted bisulfite sequencing, meDIP-seq, RIME.
• Have processed over a thousand commercial samples, including many different cell types and tissues from many different species, organoids, primary tumors, xenografts, and precious clinical samples, and made many.
• In charge of guiding automation of workflows on Beckman Coulter Biomek i7 liquid handling platform

• Used novel approach to identify lineage-determining transcription factors of kidney proximal tubule cells
• Characterized transdifferentiation potential of identified transcription factors in various cell culture models using molecular, cellular and systems biology approaches
• Identified novel transcriptional regulation mechanisms of major drug transporters Organic Anion Transporters 1 and 3 (Oat1/Slc22a6 and Oat3/Slc22a8)
• Worked with kidney organoid models to study nephrogenesis
• Worked on integrating epigenomic, transcriptomic and metabolomic datasets to gain insight into drug transporter regulation

San Diego, CA

• Developed ChIP-seq kit that made it to market
• Played integral role in experimental design, assay development, SOP troubleshooting and optimization
• Independently performed commercial assays from raw sample to finalized data

La Jolla, CA

• Produced recombinant proteins for crystallography (led to resolved crystal structure of drug target)
• Optimized expression and in vitro activation of target proteins
• Performed numerous protein characterization assays to evaluate sample fidelity

Doctor Of Philosophy (Ph.D.), Biomedical Sciences: Multi-Scale Biology

Bachelor'S Degree, Bioengineering:Biotechnology

Education record