Alexander Goncearenco Email & Phone Number

Bethesda, Md, Us

New York, Ny, Us

New York, Ny, Us

New York, Ny, Us

Machine learning driven Drug Discovery

Bethesda, Md, Us

Translational research. Developing and optimizing a sensitive experimental protocol and computational methods for early detection of cancer in cell-free DNA in blood plasma samples. Creating R and Python packages powered by ML for epigenetic analysis of sequencing and Illumina methylation array data

Bethesda, Md, Us

• Designed methods and developed server for analysis of mutational signatures in tumors and prediction of cancer driver mutations outperforming other methods (MutaGene)• Quantified the effects of epigenetic factors linked to cancer mutagenesis• Derived statistical potentials and developed AI approaches for scoring protein interfaces and inferring structural interactomes with applications to drug repurposing (IBIS)

Bethesda, Md, Us

• Studied evolution of protein binding sites and applied this knowledge to prediction of specificity in protein interfaces at residue-level resolution• Developed novel methods for building structural protein-protein interactomes on a large scale• Designed algorithms and methods for integrative analysis of cancer genomics data

Bethesda, Maryland, Us

• Designed and taught the course covering Machine and Deep Learning with Python• Communicated Machine Learning concepts and best practices to non-experts

Bergen, No

• Developed the server for analysis of allosteric regulation in protein function (SPACER)• Discovered and characterized building blocks of enzymatic functions; developed probabilistic models for application to protein design; this approach has been experimentally verified in collaboration with Dan Tawfik and David Baker labs• Identified and annotated the descriptors/structure-sequence motifs of nucleotide ligand binding (NBDB database)• Characterized the determinants of thermophilic and aerobic adaptation in prokaryotes on DNA, RNA, protein and protein interactions levels

Bergen, No

Rehovot, Hamerkaz, Il

In close collaboration with Dan Tawfik lab working on directed protein evolution reconstructed ancestral prototypes of nucleotide and dinucleotide bonding and hydrolysis functions in ancient protein folds, such as Rossmann fold and P-loop hydrolase. This work lead to a PNAS publication in collaboration with David Baker lab.

Mountain View, Ca, Us

Implemented support for chemical data formats in Strigi search engine for the KDE project (similar to Spotlight on Mac)

Brussels, Be

Built a cardio toxicity screening models (Long QT Syndrome) validated with mutagenesis and patch clamping

Chişinău, Chișinău, Md

Systems design and development at an IT consulting startup. Team growth from 1 to 20. Numerous successful deployments

Developed databases, full-text search engines and high load content management solutions

Doctor Of Philosophy - Phd, Computational Biology And Biophysics

Master'S Degree, Biomedical Sciences And Bioinformatics

Master'S Degree In Computer Science