Pat Brady Email & Phone Number

Self-driven computational scientist and action-oriented doer with 20+ years of pharma experience defining data & computational strategy, developing custom computational infrastructure and directly impacting therapeutic programs • Led a small team of Ph.D. computational chemists for ~20 years to impact drug discovery via infrastructure development & applied computation and analytics• Led the Screening Analytics SIG in GSK for 14 years and coordinated analytics support for the global HTS portfolio• Led an educational program in GSK that has provided pragmatic data science training to hundreds of Discovery scientists over 6 years • Provided direct computational support for over 50 therapeutic projects in hit identification, hit to lead, and lead optimization phases • Developed and deployed dozens of custom cheminformatics and computational chemistry domain-focused applications in support of drug discovery programs and initiatives in GSKFull CV available upon requestComp Sci Expertise: Analytics automation; biological fingerprints & target/assay clustering; chemical clustering & diversity sampling; cheminformatics, data acquisition & manipulation; data visualization; hit triage; library enumeration & multi-objective combinatorial library design; molecular docking; molecular superposition; pharmacophore fingerprints; protein binding site mapping; relational databases (oracle, mysql, dbm); scientific software development; software engineering & web deployment; screening analytics (HTS, ASMS, DEL, FBS, CETSA); structure-based design; teaching & hands-on data science instruction; virtual screening for scaffold hopping (3D & 2D) and SAR hit expansion (2D)Software: Tibco Spotfire (visualization); RDKIT; CCG software (MOE, Pharmacophore searching); OpenEye tools (FastROCS/ROCS, Omega, OEChem); Chemaxon tools; Schrodinger software (Maestro, Glide).Languages: python, perl, c++/c, php, SQL (mysql, oracle), CUDA (c) Systems: Fluent in unix (linux, irix) and windows operating systems; experienced in cpu/gpu cluster computing & queueing (slurm, sge, & lsf queuing)

Listed skills include Drug Discovery, Pharmaceutical Industry, Drug Development, Drug Design, and 4 others.