A. Graham Pockley, Phd

A. Graham Pockley, Phd Email and Phone Number

CEO, multimmune GmbH / Emeritus Professor / Cancer Immunobiology & Immunotherapy / Entrepreneur @ multimmune GmbH
munich, bayern, germany
A. Graham Pockley, Phd's Location
Munich, Bavaria, Germany, Germany
A. Graham Pockley, Phd's Contact Details

A. Graham Pockley, Phd work email

A. Graham Pockley, Phd personal email

n/a
About A. Graham Pockley, Phd

I am the CEO of multimmune GmbH, Munich, Emeritus Professor of Immunobiology (Nottingham Trent University) and Chief Scientific Officer of Alphageneron Pharmaceuticals Inc. USA, Radiance Biopharma Inc. USA and ExoCellular Diagnostics Inc. USA. I am also the former Director of the John van Geest Cancer Research Centre at Nottingham Trent University, UK, and was also the Founder and CEO of the flow cytometry resource Chromocyte, the assets of which were sold to Biocompare.My career has focused on the immunobiology of disease, the development of new immunotherapeutic strategies for treating aggressive and 'orphan' cancers, new approaches for analysing and interpreting complex datasets and defining new biomarkers of disease presence, status and response to therapy in patients with cancer.multimmune GmbH is a private, clinical-stage biopharmaceutical company which has developed a unique and proprietary technology platform on the basis of the founding scientists'​ (Professor Gabriele Multhoff, Dr Claus Botzler) discovery that cell surface-bound Hsp70 is uniquely expressed on a large proportion of cancers (~50-75%), but not on healthy cells. This makes this form of Hsp70 an excellent and broadly-applicable molecule on which to base the development of innovative therapeutics and diagnostics ('theranostics').I have extensive experience at the interface of academia and translational research and can provide a broad range of insights and advice in a number of areas and disciplines:Development of cancer theranosticsImmunoregulatory mechanisms in health and diseaseImmunobiology of heat shock (stress) proteinsCancer ImmunotherapiesMulti-parameter flow cytometryFlow cytometry functional assaysImmunoassay developmentCell-based assays

A. Graham Pockley, Phd's Current Company Details
multimmune GmbH

Multimmune Gmbh

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CEO, multimmune GmbH / Emeritus Professor / Cancer Immunobiology & Immunotherapy / Entrepreneur
munich, bayern, germany
Website:
multimmune.com
Employees:
2
A. Graham Pockley, Phd Work Experience Details
  • Multimmune Gmbh
    Chief Executive Officer
    Multimmune Gmbh Oct 2015 - Present
    Munich Area, Germany
    multimmune GmbH is a private, clinical-stage biopharmaceutical company which has developed a unique and proprietary technology platform on the basis of the founding scientists' (Professor Gabriele Multhoff, Dr Claus Botzler) discovery that cell surface-bound Hsp70 is uniquely expressed on a large proportion of cancers (~50-75%), but not on healthy cells. This makes this form of Hsp70 an excellent and broadly-applicable molecule on which to base the development of innovative therapeutics and diagnostics ('theranostics').A Phase I clinical trial of our first generation, non-expanded TKD/IL-2 activated autologous NK cell therapy (ENKASTIM™) involving eleven (11) patients with metastatic colorectal cancer and one (1) patient with non-small lung cancer (NSCLC) after standard of care (SOC) in Germany demonstrated safety and signs of efficacy. A Phase IIa (randomized, controlled) clinical trial of ENKASTIM™ involving fourteen (14) patients with advanced (Stage IIIb) NSCLC conducted in Germany demonstrated promising clinical benefit and survival.Alphageneron Pharmaceuticals Inc. USA and multimmune GmbH, Germany signed an Exclusive Worldwide License, and an Option to Purchase Agreement for its immunotherapy and diagnostics platform technology, in 2020.An Investigator-Initiated IND for a Phase I/IIa Clinical Open Label Combination Trial with our licensees' (Alphageneron Pharmaceuticals Inc.) next generation expanded, TKD/IL-2 activated autologous NK cell drug product (AP-144™) in combination with KEYTRUDA (pembrolizumab) in patients with metastatic (Stage IV) NSCLC in the United States is currently under consideration by the FDA.
  • Radiance Biopharma Inc.
    Chief Scientific Officer / Member Of Scientific Advisory Board
    Radiance Biopharma Inc. Nov 2023 - Present
    Boston, Massachusetts, United States
    Radiance Biopharma, Inc. (“Radiance”) is a privately-held immunooncology focussed biotechnology company developing next generation Antibody Drug Conjugates (ADCs). ADCs comprises a monoclonal antibody or monoclonal antibodies that are directed towards target antigens expressed on the cancer cell surface conjugated to a cytotoxic payload via a chemical linker. This approach reduces systemic exposure to toxic drugs and and therefore toxicity and harmful side-effects. Radiance is developing novel ADCs that have a better safety profile by reducing the incidence of off-target side effects.Our lead product candidates are RB-201™, a bispecific ADC targeting tumors co-expressing HER-2 and TROP-2 and RB-203™, an ADC targeting tumors expressing an undisclosed target (‘XXX’).
  • Exocellular Diagnostics Inc.
    Chief Scientific Officer / Member Of Scientific Advisory Board
    Exocellular Diagnostics Inc. May 2023 - Present
    Boston, Massachusetts, United States
    We are a pioneering biotechnology company specializing in liquid biopsy-based cancer diagnostic tests. With headquarters in Cambridge, Massachusetts, USA and facilities in Munich, Germany, we are committed to developing and commercializing innovative liquid biopsy-based tests for cancer detection/diagnosis and disease monitoring.The concept of measuring exosomal Hsp70 as a cancer-specific biomarker and its diagnostic potential developed by multimmune GmbH has been studied in 448 patients covering a range of different cancer settings (head and neck cancer, colorectal cancer, pancreatic cancer, glioblastoma, hematological malignancy, breast cancer, non small cell lung cancer). All data have been published in multiple internationally peer-reviewed publications.
  • Alphageneron Pharmaceuticals, Inc.
    Chief Scientific Officer / Member Of Scientific Advisory Board
    Alphageneron Pharmaceuticals, Inc. Aug 2021 - Present
    Boston, Massachusetts, United States
    Alphageneron Pharmaceuticals Inc., USA and multimmune GmbH, Germany signed an Exclusive Worldwide License, and an Option to Purchase Agreement for its immunotherapy and diagnostics platform technology, in 2020.Alphageneron Pharmaceuticals Inc. is developing targeted autologous and allogeneic natural killer cell (‘NK cell’) cancer therapeutics for a number of indications, all of which are supported by a Companion Diagnostic. The Company’s lead clinical autologous therapy, AP-144™, is a 2nd generation autologous NK cell therapy originally developed by multimmune GmbH (ENKASTIM™) which involves the ex vivo activation of NK cells that have been expanded from the peripheral blood of patients to recognize and target tumors expressing a membrane form of heat shock protein 70 (Hsp70) by incubation with an Hsp70-derived peptide (‘TKD’) and low dose IL-2. Membrane Hsp70 is highly expressed by a wide range of cancers, but not by normal cells. The membrane Hsp70 expression status of a patient’s tumor is detected by measuring serum/plasma levels of circulating exosomal Hsp70 using a Companion Diagnostic ELISA.
  • Cytomos
    Member, Scientific Advisory Committee
    Cytomos Jan 2022 - Present
    Edinburgh, Scotland, United Kingdom
    Cytomos is a dynamic early-stage company developing ground-breaking cell analysis systems that can be used alone or alongside conventional technologies such as flow cytometry. Cytomos Dielectric Spectroscopy (CDS) leverages cost-efficient microchip technology, providing streamlined testing strategies and economically viable cell therapies. The technology closely monitors a broad range of individual cell features simultaneously and collects data on intrinsic cellular properties in real-time, delivering unbiased, consistent, accurate and reliable predictive analytics for biomanufacturing and other applications.
  • Nottingham Trent University
    Emeritus Professor Of Immunobiology
    Nottingham Trent University Aug 2022 - Present
    Nottingham, England, United Kingdom
  • John Van Geest Cancer Research Centre, Nottingham Trent University
    Former Director & Professor Of Immunobiology
    John Van Geest Cancer Research Centre, Nottingham Trent University Oct 2020 - Jul 2022
    Nottingham, England, United Kingdom
  • John Van Geest Cancer Research Centre, Nottingham Trent University
    Director & Professor Of Immunobiology
    John Van Geest Cancer Research Centre, Nottingham Trent University Sep 2016 - Sep 2020
    Nottingham, United Kingdom
    The John van Geest Cancer Research Centre was established in 2008, as a new research centre within the School of Science and Technology, as a direct result of core funding from the John and Lucille van Geest Foundation. This funding provided a £5m purpose-built Research Centre and a grant support for a team of more than 35 scientists, technicians and graduate students.Research focuses on the discovery and application of new cancer biomarkers for detecting cancer, monitoring disease progression, predicting therapeutic responses and developing new immunotherapeutic approaches. Progress in these areas is based on a fundamental understanding of cancer cell biology and immunobiology. The Centre is well equipped for the challenge of modern day cancer research, incorporating state-of-the-art flow cytometry and cell sorting instruments and technologies for discovering the genetic basis of the disease and developing new methods of diagnosis and treatment.
  • Nottingham Trent University
    Associate Director & Professor Of Immunobiology
    Nottingham Trent University May 2012 - Sep 2016
    Nottingham, United Kingdom
  • Agp Bio Limited
    Founder & Ceo
    Agp Bio Limited Nov 2021 - Present
    Sheffield, England, United Kingdom
    Scientific, Biomedical and Pharma Consultancy
  • Chromocyte Limited
    Founder & Ceo
    Chromocyte Limited Nov 2009 - Nov 2021
    Sheffield, United Kingdom
    Chromocyte is now a part of Biocompare, the life science's industry’s leading product resource. The Chromocyte mission continues to focus on the Flow Cytometry community with beginners guides, reagents, instruments and training courses.
  • University Of Sheffield
    Honorary Professor
    University Of Sheffield May 2012 - May 2021
    Sheffield, United Kingdom
  • University Of Sheffield
    Professor Of Immunobiology
    University Of Sheffield Oct 2004 - Apr 2012
    Sheffield, United Kingdom
  • University Of Sheffield
    Reader In Immunobiology
    University Of Sheffield Oct 1996 - Oct 2004
    Sheffield, United Kingdom
  • The University Of Sheffield
    Lecturer In Immunobiology
    The University Of Sheffield Sep 1994 - Oct 1996
  • Medical College Of St Bartholomew'S Hospital & C
    Non-Clinical Lecturer In Transplantation Immunology
    Medical College Of St Bartholomew'S Hospital & C Jan 1991 - Sep 1994
    London, England, United Kingdom
  • Wayne State University School Of Medicine
    Postdoctoral Research Associate In Mucosal Immunology
    Wayne State University School Of Medicine Nov 1988 - Dec 1990
    Detroit, Michigan, United States
  • Sheffield Hallam University
    Postgraduate Research Assistant In Reproductive Immunology (Phd)
    Sheffield Hallam University Sep 1985 - Nov 1988
    Sheffield, England, United Kingdom

A. Graham Pockley, Phd Skills

Flow Cytometry Immunology Cell Cancer Life Sciences Assay Development Science Molecular Biology Biotechnology Cell Biology Immunoassays Cell Culture Lifesciences Cancer Research Facs Biochemistry Confocal Microscopy Monoclonal Antibodies Antibodies Oncology Biomarkers Genetics Clinical Research Cancer Immunotherapy Immunotherapy Elisa Cell Based Assays Microbiology Protein Chemistry Biology University Teaching Western Blotting Science Education Drug Discovery Biomarker Discovery Medical Diagnostics Scientific Writing Stem Cells Community Sites Online Communities Flow Cytometry Antibodies Flow Cytometry Assay Development Tumor Immunotherapy Entrepreneurship Innovator Antibody Search Flow Cytometry Technology Entrepreneur Proteomics Consultancy

A. Graham Pockley, Phd Education Details

Frequently Asked Questions about A. Graham Pockley, Phd

What company does A. Graham Pockley, Phd work for?

A. Graham Pockley, Phd works for Multimmune Gmbh

What is A. Graham Pockley, Phd's role at the current company?

A. Graham Pockley, Phd's current role is CEO, multimmune GmbH / Emeritus Professor / Cancer Immunobiology & Immunotherapy / Entrepreneur.

What is A. Graham Pockley, Phd's email address?

A. Graham Pockley, Phd's email address is gr****@****yte.com

What schools did A. Graham Pockley, Phd attend?

A. Graham Pockley, Phd attended Sheffield Hallam University, The University Of Sheffield, Hymers College.

What are some of A. Graham Pockley, Phd's interests?

A. Graham Pockley, Phd has interest in Entrepreneurialism, Sheep Farming, Science, Education, Translational Medicine, New Technologies, Bio Pharma.

What skills is A. Graham Pockley, Phd known for?

A. Graham Pockley, Phd has skills like Flow Cytometry, Immunology, Cell, Cancer, Life Sciences, Assay Development, Science, Molecular Biology, Biotechnology, Cell Biology, Immunoassays, Cell Culture.

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