Graham Clarke Email and Phone Number
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I have extensive experience building organisations and alliances, directing initiatives and programmes with a focus on precision medicine, understanding disease, treatment targeting and MOA-target biomarkers to promote portfolio differentiation, lower development costs with a higher probability of success across Immunology, Infection and Respiratory Therapeutic Areas.Key strengths include: CRO and Pharmaceutical industry leadership and human cultural awareness to bring together fragmented business deliverables and the right people to deliver best thinking and solutions. High energy and rapid engagement to assess context, business, and consumer needs. Blend of business delivery and clinical/ scientific insight to address opportunities for growth and differentiation. Strong nurturing mentoring leadership style who leads with compassion and empowering others to succeed.
Astrazeneca
View- Website:
- astrazeneca.com
- Employees:
- 78605
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Head Of Translation Science Portfolio Delivery, Early R And I, Research And Development BiopharmaceuticalsAstrazenecaGothenburg, Se
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Senior Director , Translational Science, Early R&I, Research & Development BiopharmaceuticalsAstrazeneca Dec 2018 - PresentCambridge, Cambridgeshire, GbLeading Successful Collaborations and Building Organisations:• Led and closed 4yr fully integrated strategic collaboration agreement with specialistCRO promoting the discovery, development, and diagnostic potential of predictivebiomarkers in fibrotic disease across the Early R&I portfolio• Leading integrated Rare Disease/ Immunology precision medicine operationalstrategies through Alexion/ AZ – linking through CRO Alliance partnering• Led re-structuring preferred provider rate card with key proteomic platform provider todrive 25-35% saving across portfolio• Enabling Precision Medicine: AZ Lead for 3TR-IMI Consortium-– enabling opportunitiesto differentiate established brands (Tezspire) and accelerating mechanistic insights forearly Immunology (RA/SLE) and COPD assets through sample and omic data access• Responsible for the implementing breathomics strategy and road map to integratedomics connecting targets and biomarkers to clinical line of sight• Architect of new functional biomarker operations group to articulate risk to delivery andprovide proactive mitigation steps to influence costs and timelines• Engineered Great Place to Work framework for the group - resulting in a net 18%improvement on key indices such as operational effectiveness and communication overa 6-month period
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Interim Head Of Biomarker Discovery, Early R&I, Research & Development BiopharmaceuticalsAstrazeneca May 2019 - Jun 2020Cambridge, Cambridgeshire, Gb
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Visiting ProfessorKing'S College London Apr 2023 - PresentLondon, Greater London, Gb• Consulted on successful award of investment for new diagnostic unit.• Drug development investment/ decision criteria- triaging a target to market.• Precision Medicine in Immunological Disease / Trial design and execution -
Honorary Senior LecturerImperial College Jun 2007 - PresentLondon, Gb• Collaborated in developing an industry leading ex-vivo -human in vitro personalised cytokine storm response assay for early compound development.https://bps.conference-services.net/resources/344/3974/pdf/PHARM15_0204.pdf• Currently lecture on Respiratory drug development, Clinical pharmacology and innovations in human in vitro assay development in adaptive/integrated study designs. -
Research FellowImperial College Oct 2006 - Jun 2007London, Gb• Responsible for the conduct and co-ordination of research ethics and clinical trials within the department of Cardiothoracic Pharmacology. • Initiated clinical and laboratory services to include pulmonary and bronchial blood flow procedures in patients with pulmonary hypertension and COPD.
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Vice President, Clinical Operations And Model DevelopmentHvivo Oct 2016 - Nov 2018London, England, GbChange Management and Business Growth• Responsible for delivering the Precision Development Framework – connecting new “Tool Kit” products and predictive algorithms from R&D to the clinic. • Responsible for enabling the delivery $30-40M / year portfolio.• High focus on change and process management creating a flexible and adaptable clinical and trial management team.• Responsible for a 100+ staffed division with Director level line reports.• Responsible for the profitable and efficient management of Viral Challenge quarantine units and UK and US screening centres. -
Senior Director, Head Of Respiratory & Inflammation Early Clinical Development, Quintiles LtdQuintilesims Apr 2014 - Jun 2016Durham, North Carolina, UsStrategic and Operational Leadership:• Responsible for developing novel strategies to accelerate clinical development programmes, optimising operational conduct and providing expert subject matter scientific in-put to over 80 first time in man (FTIM) and first time in patient (FTIP) respiratory and allergy indicated studies.• Directly lead clinical and laboratory teams and provided matrix management leadership across several preferred providers mid to large pharma and emerging biotech programmes.• Created a KOL and global partner site network focusing on key indicators such as patient recruitment, scientific and technical expertise with emphasis on data quality and timelines.Thought leadership and Innovation:• Highly experienced in developing generic inhaled devices for bioequivalence studies and integrated study SAD/MAD/POC designs involving challenge test such as Allergen and LPS.• Created a new GP/primary care outreach service to improve COPD, diabetes and GI patient engagement and recruitment. Saw 30%+ increase in COPD screening appointments.• Created the BIOSPIT initiative and global tissue distribution uniting Quintiles ECD, Later phase groups and Global Laboratories to improve sputum data outcomes in multi-centre trials. https://www.ncbi.nlm.nih.gov/pubmed/?term=BIOSPIT -
Director, Respiratory & Inflammation Early Clinical Development, Quintiles LtdQuintilesims Aug 2012 - Apr 2014Durham, North Carolina, UsI lead a highly professional and dedicated multi-disciplinary team, creating two highly successful and fully integrated clinical and biomarker development departments.
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Associate Director, Respiratory Therapeutic Area- Phase 1Quintilesims Apr 2010 - Aug 2012Durham, North Carolina, Us
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Manager, Clinical Physiology & Respiratory Therapeutic Head Phase 1Quintilesims Aug 2008 - Apr 2010Durham, North Carolina, Us
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Chief Scientific Officer And Lead PhysiologistRespiratory Clinical Trials Ltd Jun 2007 - Aug 2008• Responsible for the operation of the private cardio-pulmonary service and the clinical trials laboratory service for RCT Ltd within this niche boutique CRO.• Created a new central site facility for multiplex analytical platform analysis, whole blood FACS analysis and neutrophil elastase activity assays from airway samples.
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Chief Clinical PhysiologistKing'S College London Jan 2006 - Nov 2006London, Greater London, Gb• Following the submission of my PhD, I was responsible for the performance and monitoring of all physiological measurements to the highest standards in this academic Phase II-IV CRO. I trained nurses, technicians and junior physiologists to perform spirometry, body plethysmography, exhaled nitric oxide and a number of protocol specific respiratory investigations. • Extended my PhD research to assess the impact of inhaled allergen on vascular and airway responses in asthma and healthy volunteers.
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Senior Clinical PhysiologistKing'S College London Nov 2000 - Feb 2002London, Greater London, Gb
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Clinical PhysiologistRoyal Brompton Hospital Apr 1999 - Nov 2000London, Gb -
Dna AnalystLgc Limited Oct 1998 - Apr 1999Teddington, Middlesex, GbWorking for the national DNA database for the Laboratory of the Government Chemist as a DNA analyst. Duties included DNA extraction, PCR, sequencing and analysis. -
Scientific OfficerCancer Research Uk Jun 1998 - Oct 1998London, GbFollowing a successful industrial placement the previous year at the Applied Development Laboratoratories at Bart's Hospital (based as the formerly named ICRT - Imperial Cancer Research Technology), I was employed soon after the end of my degree to cover a maternity placement. Researched the putative tumour supressor gene PTEN
Graham Clarke Skills
Graham Clarke Education Details
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King'S College LondonRespiratory Pharmacology And Physiology. - -
Kingston UniversityBiomedical Sciences
Frequently Asked Questions about Graham Clarke
What company does Graham Clarke work for?
Graham Clarke works for Astrazeneca
What is Graham Clarke's role at the current company?
Graham Clarke's current role is Head of Translation Science Portfolio Delivery, Early R and I, Research and Development BioPharmaceuticals.
What is Graham Clarke's email address?
Graham Clarke's email address is gr****@****les.com
What schools did Graham Clarke attend?
Graham Clarke attended King's College London, Kingston University.
What skills is Graham Clarke known for?
Graham Clarke has skills like Clinical Research, Clinical Trials, Respiratory Therapy, Clinical Development, Drug Development, Pharmacology, Asthma, Immunology, Copd, Dna, Cro, Laboratory.
Who are Graham Clarke's colleagues?
Graham Clarke's colleagues are Yana Koleva, Persin Kaur, Dolly, Margarita Fernandez-Chas, Andrew Alexander R, Jimmy Carlsson, 류채영, Sanjeev Puri.
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