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Seattle-based inflammation and immuno-oncology researcher with a track record of innovation and achievement spanning large and small molecule discovery, cell therapy, translational research and clinical program support. Enthusiastic leader, with the ability to solve complex problems and build strong relationships both within teams and across disciplines.• Deep and intuitive understanding of immunology and cancer biology• Broad technical fluency and strategic vision • Committed team player with proven skills in building internal and external scientific collaborations • Excellent written and oral communication skills with experience writing research publications, patent applications and regulatory filingsSpecialties: Immunology, Cancer Biology, Inflammation, CAR-T cells, In vivo Pharmacology, Antibody Engineering, Apoptosis, Signal Transduction, Discovery Research, Translational Research, Clinical Study Support, Teamwork, Creative Problem Solving, Mentoring.
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Head Of Discovery ResearchArchon Biosciences Jun 2023 - PresentSeattle, Washington, Us -
Senior Director Of ImmunologyIfm Therapeutics Feb 2017 - Apr 2022
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Director Of ImmunologyTcr2, Inc. Feb 2016 - Dec 2016Led a team of 6 research scientists responsible for a broad range of scientific activities at a startup with novel technology in the CAR T cell space.• Designed and implemented workflows for selection of lead candidates for multiple tumor targets• Generated in vitro and in vivo mechanism of action and proof of concept data for several targets across solid and hematological tumor indications• Developed a prototype T cell manufacturing process for transfer to CMO• Provided data and technical support for 6 patent filings
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Senior Principal ScientistTesaro Aug 2014 - Feb 2016Waltham, Massachusetts, UsResponsible for pre-clinical activities for anti-PD-1, anti-Tim-3, anti-Lag-3 and bispecific antibody candidates at a company with no in-house research capabilities.• Managed relationships with partners and CROs to ensure acquisition of key preclinical data• Generated the in vitro and in vivo pharmacology packages for multiple IND applications• Implemented translational strategies in support of dose, indication and patient selection • Evaluated immuno-oncology in-licensing opportunities -
Principal ScientistAileron Therapeutics 2012 - 2013Team leader for stapled peptide programs targeting intracellular anti-apoptotic targets. • Responsible for team strategy and translational studies• Designed and supervised workflows in support of mechanism of action and lead selection
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Principal ScientistAmgen 2010 - 2012Thousand Oaks, Ca, UsGlobal Biology Leader and Project Strategy Team member for the Conatumumab (AMG 655) DR5 agonist antibody program. Responsible for pre-clinical strategy and ensuring cross-functional alignment.• Generated key mechanism of action and patient stratification hypotheses that significantly impacted translational and clinical development strategies• Developed proof of concept biomarker and product quality assays• Wrote study reports and preclinical components of IND and IB documents• Represented Research and Translational functions in meetings with the FDA and NCI/CTEP as well as with Advisory Boards and clinical trials consortia• Experienced in preclinical modeling of antibody-immune cell interactions and effector function using in vitro, ex vivo and syngeneic in vivo models -
Senior ScientistAmgen 2004 - 2010Thousand Oaks, Ca, UsTeam leader responsible for target discovery, validation, and lead selection for a small molecule Mcl-1 inhibitor program (AMG 176).• Leveraged cell-based, in silico and proteomic analyses to identify multiple hits• Established multi-disciplinary project teams and coordinated complex cross-functional efforts to support project advancement• AMG 176 is currently in phase-I clinical trials in multiple myeloma
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Research Assistant ProfessorUniversity Of Washington, Department Of Immunology 1998 - 2004Seattle, Wa, UsStrong research, funding and publication record in mitogenic and apoptotic signal transduction research. Focused on regulatory cross-talk between caspases and signal transduction pathways that regulate survival, proliferation and differentiation in lymphocytes.
Jonathan Graves Skills
Jonathan Graves Education Details
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University Of WashingtonDepartment Of Pharmacology -
Cetus/Onyx PharmaceuticalsBiochemistry/Cell Biology
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Cancer Uk/University College LondonBiochemistry/Cell Biology
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King'S College LondonImmunology
Frequently Asked Questions about Jonathan Graves
What company does Jonathan Graves work for?
Jonathan Graves works for Archon Biosciences
What is Jonathan Graves's role at the current company?
Jonathan Graves's current role is Head of Research.
What is Jonathan Graves's email address?
Jonathan Graves's email address is jo****@****ast.net
What schools did Jonathan Graves attend?
Jonathan Graves attended University Of Washington, Cetus/onyx Pharmaceuticals, Cancer Uk/university College London, King's College London.
What are some of Jonathan Graves's interests?
Jonathan Graves has interest in Sea Kayaking, Home Improvement, Scuba Diving, Djing And Electronic Music Production, Biking.
What skills is Jonathan Graves known for?
Jonathan Graves has skills like Immunology, Biomarkers, Assay Development, Cell Biology, Molecular Biology, Antibodies, Cell, Drug Discovery, Biotechnology, Signal Transduction, Biochemistry, In Vivo.
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