Scientific Leadership and Innovation* Formed Development org; scaled team to 10+ molecular, computational, and IVD scientists; set high-level department goals, resourcing, and budgeting* Led development of a high-sensitivity cfDNA methylation technology, which is the foundation of Freenome’s first IVD for colorectal cancer screening* Partnered with research, computational biology and machine learning teams in developing multiomics platform for biomarker discovery

Molecular and Computational Biology Expertise* Gained product development expertise by contributing to the development of multiple clinical products - non-invasive prenatal screening (PrequelTM), expanded carrier screening (ForesightTM), and hereditary cancer screening (ReliantTM) - see publications & posters* Managed a team of four scientists to develop new products or features for implementation in a high-volume clinical lab (CLIA/CAP)* Distilled clear and actionable conclusions from retrospective analysis of high-throughput sequencing data (using Python, R); provided expert review of clinical results* Implemented algorithms for higher call accuracy and fewer assay failures; developed methods to monitor and account for systematic bias or errors (using Python)

Advisors: Dr. Patrick O. Brown and Dr. Daniel Herschlag* Developed multiple genomic technologies to study the function and evolution of RNA binding proteins and their RNA targets* Developed new bioinformatic approaches (using R, Perl) by integrating knowledge and tools from the fields of comparative genomics, evolutionary biology, and gene regulation* Collaborated on projects both inside and outside the department, resulting in 4 publications

Advisor: Dr. Bas van Steensel* Leveraged nascent technologies to study heterochromatin protein 1 (HP1) in Drosophila melanogaster, uncovering a surprising role in promoting transcription at euchromatic gene targets* Adapted a method for assaying chromatin accessibility called FAIRE for use with cultured fly cells; collaborated with a graduate student to study the relationship between chromatin accessibility and deposition of histone proteins H1 and H3.3

Advisor: Dr. Jason D. Lieb* Used DNA microarrays to study nucleosome occupancy and histone methylation, culminating in first-author and second-author publications